One of the common errors in the calculation of the population attributable fraction (PAF) is the use of an adjusted risk ratio in the Levin formula. In this article, we discuss the errors visually using wireframes by varying the standardized mortality ratio (SMR) and associational risk ratio (aRR) when the prevalence of exposure is fixed. When SMR ...
This manuscript provides a summary of the research I have conducted or supervised between 2010and 2024, in the field of biostatistics applied to the mathematical modeling of infectious diseases.My presentation is structured into three parts: the methodological development for the use ofmechanistic models, their application to the intra-host modelin...
Cette thèse s'inscrit dans le domaine de l'éthique computationnelle dont le but est de formaliser le raisonnement éthique. Autrement dit, ce travail fait partie du domaine qui cherche à reproduire notre capacité en tant qu'êtres rationnels à évaluer moralement une action. Deux objectifs sont recherchés au travers de la formalisation de ce raisonnem...
Published in Scientific reports
Although serum iron status and sarcopenia are closely linked, the presence of comprehensive evidence to establish a causal relationship between them remains insufficient. The objective of this study is to employ Mendelian randomization techniques to clarify the association between serum iron status and sarcopenia. We conducted a bi-directional Mend...
International audience
Most of the scientific literature on causal modeling considers the structural framework of Pearl and the potential-outcome framework of Rubin to be formally equivalent, and therefore interchangeably uses the do-notation and the potential-outcome subscript notation to write counterfactual outcomes. In this paper, we agnostically superimpose the two ...
Differential participation in observational cohorts may lead to biased or even reversed estimates. In this article, we describe the potential for differential participation in cohorts studying the etiologic effects of long-term environmental exposures. Such cohorts are prone to differential participation because only those who survived until the st...
BACKGROUND: Many observational studies support light-to-moderate alcohol intake as potentially protective against premature death. We used a genetic approach to evaluate the linear and nonlinear relationships between alcohol consumption and mortality from different underlying causes. METHODS: We used data from 278 093 white-British UK Biobank parti...
Published in European Neurology
Introduction: The aim of this study was to investigate the causal relationship between Parkinson’s disease (PD) and myocardial infarction (MI), atrial fibrillation and flutter (AF), and venous thromboembolism (VTE) by Mendelian randomization (MR) analysis. Methods: By using data from publicly available genome-wide association studies from databases...
