Tavalaee, Marziyeh Rahmani, Mohsen Drevet, Joël R. Nasr-Esfahani, Mohammad Hossein
Published in
Basic and Clinical Andrology
Background Infertility related to varicocele, infections, metabolic dysfunctions, oxidative stress and environmental toxicants is also associated with inflammatory processes that ultimately lead to the activation of the inflammasome pathway (IP). IP is classically activated by DAMPs, MAMPs or LAMPs, which stand for Damage-, Microbe- or Lifestyle-As...
Duveau, Damien Y. Thomas, Craig J.
Published in
ACS Pharmacology & Translational Science
The SARS-CoV-2 main protease is among the most attractive targets for the development of therapeutic interventions for COVID-19. Successful candidate agents will not only possess potent on-target activity versus SARS-CoV-2 Mpro but also minimal polypharmacology versus human cysteine proteases. This Viewpoint explores the activity profile of the fir...
Prendecki, M McAdoo, SP Turner-Stokes, T Garcia-Diaz, A Orriss, I Woollard, KJ Behmoaras, J Cook, HT Unwin, R Pusey, CD
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P2RX7, an ionotropic receptor for extracellular ATP, is expressed on immune cells, including macrophages, monocytes and dendritic cells and is up-regulated on non-immune cells following injury. P2RX7 plays a role in many biological processes, including production of pro-inflammatory cytokines such as IL-1β via the canonical inflammasome pathway. P2...
Digby, Zsofi Tourlomousis, Panagiotis Rooney, James Boyle, Joseph P Bibo-Verdugo, Betsaida Pickering, Robert J Webster, Steven J Monie, Thomas Hopkins, Lee J Kayagaki, Nobuhiko
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Zoonotic pathogens, such as COVID-19, reside in animal hosts before jumping species to infect humans. The Carnivora, like mink, carry many zoonoses, yet how diversity in host immune genes across species affect pathogen carriage is poorly understood. Here, we describe a progressive evolutionary downregulation of pathogen-sensing inflammasome pathway...
Kolachala, Vasantha L Lopez, Chrissy Shen, Ming Shayakhmetov, Dmitry Gupta, Nitika Arora
Published in
Apoptosis : an international journal on programmed cell death
A steatotic liver is increasingly vulnerable to ischemia reperfusion injury (IRI), and the underlying mechanisms are incompletely defined. Caspases are endo-proteases, which provide critical regulatory connections between cell death and inflammation. Caspase 1 is driven by inflammasomes which are key signaling platforms, that detect sterile stresso...
Bonte, Marie-Amandine El Idrissi, Fatima Gressier, Bernard Devos, David Belarbi, Karim
Published in
International immunopharmacology
Parkinson's disease is a progressive neurodegenerative disease associated with a loss of dopaminergic neurons in the substantia nigra of the brain. Neuroinflammation, another hallmark of the disease, is thought to play an important role in the neurodegenerative process. While mitigating neuroinflammation could prove beneficial for Parkinson's disea...
Beheshti, Masoumeh Salehi, Zahra Abolfazli, Roya Shirzad, Hedayatolah Izad, Maryam
Published in
Iranian journal of allergy, asthma, and immunology
Multiple sclerosis (MS) is an inflammatory autoimmune disease of the central nervous system, in which proinflammatory cytokines play a critical role in the pathogenic formation of lesions. Caspase-1 is a cysteine protease that proteolytically cleaves precursors of interleukin (IL)-18 and IL-1β and turns them into their active forms. These inflammat...
Doerflinger, Marcel Deng, Yexuan Whitney, Paul Salvamoser, Ranja Engel, Sven Kueh, Andrew J Tai, Lin Bachem, Annabell Gressier, Elise Geoghegan, Niall D
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Apoptosis, pyroptosis and necroptosis contribute to host protection against diverse pathogens, but their interplay and the underlying molecular mechanisms coordinating their interactions have not yet been resolved (Green, 2019). To define the relative importance of these cell death pathways and their inter-connectivity in host defence, we deleted c...
Karmakar, Mausita Minns, Martin Greenberg, Elyse N Diaz-Aponte, Jose Pestonjamasp, Kersi Johnson, Jennifer L Rathkey, Joseph K Abbott, Derek W Wang, Kun Shao, Feng
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Gasdermin-D (GSDMD) in inflammasome-activated macrophages is cleaved by caspase-1 to generate N-GSDMD fragments. N-GSDMD then oligomerizes in the plasma membrane (PM) to form pores that increase membrane permeability, leading to pyroptosis and IL-1β release. In contrast, we report that although N-GSDMD is required for IL-1β secretion in NLRP3-activ...
Tang, Tao Tao, Xuxiong Bao, Xing Chen, Jun Dai, Jingyu Ye, Jinjun Yan, Yukuang
Published in
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Background The aim of this study was to explore the influence of mitofusin-2 (Mfn-2) on phosphatidylinositol transfer protein 3 (PITPNM3) and tumor growth and the potential mechanism behind the regulation of Mfn-2 on PITPNM3 in hepatic carcinoma cell line SMMC-7721. Material/Methods We obtained promoter sequence of PITPNM3 gene from University of S...
