Monitoring indirect impact of COVID-19 pandemic on services for cardiovascular diseases in the UK.
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Impact of Guidelines on Hypertension Control in the Elderly.
Published in Current pharmaceutical design
Hypertension control is a crucial measure to reduce cardiovascular (CV) risk, and blood pressure (BP) treatment targets have been recently revised to address this issue. However, achieving the recommended goal may be challenging. We aimed to assess the prevalence of uncontrolled hypertension according to the US hypertension guidelines among elderly...
Modelling the impact of clot fragmentation on the microcirculation after thrombectomy [preprint]
Many ischaemic stroke patients who have a mechanical removal of their clot (thrombectomy) do not get reperfusion of tissue despite the thrombus being removed. One hypothesis for this ‘no-reperfusion’ phenomenon is micro-emboli fragmenting off the large clot during thrombectomy and occluding smaller blood vessels downstream of the clot location. Thi...
Incident frailty and cognitive impairment by heart failure status in older patients with atrial fibrillation: the SAGE-A...
Background: Atrial fibrillation (AF) and heart failure (HF) frequently co-occur in older individuals. Among patients with AF, HF increases risks for stroke and death, but the associations between HF and incident cognition and physical impairment remain unknown. We aimed to examine the cross-sectional and prospective associations between HF, cogniti...
Conquering hypertension in Vietnam-solutions at grassroots level: study protocol of a cluster randomized controlled tria...
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BACKGROUND: Vietnam has been experiencing an epidemiologic transition to that of a lower-middle income country with an increasing prevalence of non-communicable diseases. The key risk factors for cardiovascular disease (CVD) are either on the rise or at alarming levels in Vietnam, particularly hypertension (HTN). Inasmuch, the burden of CVD will co...
Bacteremia and Endocarditis
This presentation provides an overview of the pathogens that cause bacteremia and endocarditis. Manifestations, pathology and treatment are discussed. The goals of the presentation are: Consider major pathogens that cause bacteremia and endocarditis in both adults and children; Discuss pathogenesis; Review clinical manifestations; Discuss basic tre...
Clinical pharmacy services in Brazil, particularly cardiometabolic diseases: a systematic scoping review and meta-analys...
Published in Pharmacy Practice
Objective: To map the clinical pharmacy services conducted in Brazil, their characteristics, outcomes, and process measures in general population, as well as the assessment of the clinical impact on people with cardiometabolic diseases (cardiovascular diseases and metabolic diseases). Methods: A systematic scoping review and meta-analysis were cond...
High Salt Diet Impacts the Risk of Sarcopenia Associated with Reduction of Skeletal Muscle Performance in the Japanese P...
...Published in Nutrients
The World Health Organization has recommended 5 g/day as dietary reference intakes for salt. In Japan, the averages for men and women were 11.0 g/day and 9.3 g/day, respectively. Recently, it was reported that amounts of sodium accumulation in skeletal muscles of older people were significantly higher than those in younger people. The purpose of th...
Quantitative Characterization of Recanalization and Distal Emboli with a Novel Thrombectomy Device
PURPOSE: The first-pass effect during mechanical thrombectomy improves clinical outcomes regardless of first-line treatment approach, but current success rates for complete clot capture with one attempt are still less than 40%. We hypothesize that the ThrombX retriever (ThrombX Medical Inc.) can better engage challenging clot models during retrieva...
Platelets and COVID-19: Inflammation, Hyperactivation and Additional Questions
The mechanisms underlining thrombosis in COVID-19 patients are not known and likely due to multiple processes including inflammation, oxygen demand injury, and plaque rupture triggered by the infection. Platelets mediate thrombotic vascular occlusion but are also increasingly recognized to have immunomodulatory activity. Several of our recent studi...
