The purpose of this study is to develop a test method to non-invasively measure the development of subclinical atherosclerosis through acoustic sound wave analysis. This test method involves the manufacturing and use of silicone arteries with varying relative roughness values in their inner diameters to mimic arterial plaque buildup, a flow model, ...
Recent studies raise concern for increased risk of major adverse cardiovascular events (MACE) with Janus kinase (JAK) inhibitors used to treat immune-mediated inflammatory disorders (IMIDs). We aimed to examine MACE risk with licensed biologics and small molecules used commonly between IMIDs: inflammatory bowel disease, rheumatoid arthritis, psoria...
Published in RMD open
Cardiovascular comorbidities are common in patients with autoimmune diseases. This study investigates the extent of subclinical atherosclerosis in patients with primary Sjögren's syndrome (pSS). Correlations with clinical factors such as organ involvement (OI) or disease activity were analysed and oxLDL antibodies (oxLDL ab) were measured as potent...
Published in European journal of clinical pharmacology
Many atrial fibrillation (AF) patients use cardiovascular medications for indications other than AF. These medications can affect morbidity and mortality. We aim to investigate the characteristics of AF patients who use different medication classes and their clinical course. We collected data from the prospective, multicenter registry, JoFib study....
Published in Cardiovascular drugs and therapy
Cardiovascular disease (CVD) is the leading cause of mortality in patients with rheumatoid arthritis (RA). Some studies have reported a decrease in CVD in patients with RA using hydroxychloroquine (HCQ). Most of these have had fewer participants and have analyzed only composite outcomes. We aimed to identify the association between the use of HCQ i...
Published in European heart journal. Quality of care & clinical outcomes
This study aims to provide a timely and comprehensive estimate of the current burden and temporal trend of cardiovascular disease (CVD) attributable to high body mass index (HBMI). We systematically assessed the current burden and temporal trend of CVD attributable to HBMI by calendar year, age, sex, region, nation, socioeconomic status, and specif...
Published in Cardiovascular diabetology
It is unknown whether high hemoglobin A1c (HbA1c) is associated with increases in the risk of cardiovascular disease among individuals with elevated genetic susceptibility. We aimed to investigate the association between HbA1c and atrial fibrillation (AF), coronary artery disease (CAD), and ischemic stroke according to the polygenic risk score (PRS...
Published in Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese
Women have a higher comorbidity burden and a lower survival rate after acute myocardial infarction (AMI) than men. This analysis aimed to investigate the impact of sex on the effect of treatment with the sodium glucose cotransporter 2 inhibitor (SGLT2i) empagliflozin immediately after an AMI. Participants were randomized to either empagliflozin or ...
Stroke is an enormous global burden, six and a half-million people die fromstroke annually [1]. Effectively monitoring blood hemodynamic parameters suchas blood velocity and volume flow permits to help and cure people. This projectaimed to calibrate a custom-made wearable system for measuring cerebral bloodflow (CBF) using a photoplethysmography (P...
Maternal mortality remains high in the US and pregnancy-associated myocardial infarction accounts for over 20% of maternal cardiac deaths. The relative risk of myocardial infarction during pregnancy is approximately 3 to 4-fold higher than the rates of age-matched non-pregnant individuals in the reproductive age group. During myocardial infarction,...
