Rangasamy, Valluvan Henriques, Teresa S Mathur, Pooja A Davis, Roger B Mittleman, Murray A Subramaniam, Balachundhar
Published in
Journal of clinical monitoring and computing
Nonlinear complexity measures computed from beat-to-beat arterial BP dynamics have shown associations with standard cardiac surgical risk indices. They reflect the physiological adaptability of a system and has been proposed as dynamical biomarkers of overall health status. We sought to determine the impact of anesthetic induction and cardiopulmona...
Fujikawa, Takuya Chow, Simon C Y Chang, Aliss T C Wong, Randolph H L
Published in
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
The Djumbodis™ dissection system was introduced as an alternative to aortic arch replacement in acute type A aortic dissection involving the arch. In our own experience, some patients with Djumbodis implantation developed distal aortic arch and descending aortic aneurysm during subsequent follow-up and required additional interventions. However, as...
Hao, Xuechao Wei, Wei
Published in
BMC Anesthesiology
BackgroundFor infants undergoing complex cardiac surgery, hemodynamic management after cardiopulmonary bypass (CPB) is challenging because of severe myocardial edema, vasomotor dysfunction and weak tolerance to a change in blood volume. More importantly, the lack of availability of equipment for advanced monitoring, such as transesophageal echocard...
Sun, Haibin Zhao, Xiaoqing Tai, Qihang Xu, Guangxiao Ju, Yingnan Gao, Wei
Published in
Stem Cell Research & Therapy
BackgroundCardiopulmonary bypass (CPB) results in severe lung injury via inflammation and endothelial injury. The aim of this study was to evaluate the effect of endothelial colony-forming cells (ECFCs) on lung injury in rats subjected to CPB.MethodsThirty-two rats were randomized into the sham, CPB, CPB/ECFC and CPB/ECFC/L-NIO groups. The rats in ...
Naase, Hatam Harling, Leanne Kidher, Emaddin Sepehripour, Amir Nguyen, Bao Kapelouzou, Alkistis Cokkinos, Dennis Stavridis, George Angelini, Gianni Evans, Paul C.
...
Published in
Journal of Cardiothoracic Surgery
ObjectivesCardiac surgery can lead to post-operative end-organ complications secondary to activation of systemic inflammatory response. We hypothesize that surgical trauma or cardiopulmonary bypass (CPB) may initiate systemic inflammatory response via release of mitochondrial DNA (mtDNA) signaling Toll-like receptor 9 (TLR9) and interleukin-6 produ...
Peng, Yun-Wen Major, Terry Mohammed, Azmath Deatrick, Kristopher B. Charpie, John R.
Published in
Journal of Cardiothoracic Surgery
BackgroundIn a rabbit model of cardiopulmonary bypass (CPB) and cardioplegic arrest, we previously showed that hyperoxic myocardial reperfusion was associated with increased left ventricular (LV) systolic dysfunction and myocardial injury compared with normoxic reperfusion. The aim of this study was to evaluate in our experimental model the impact ...
Wu, Hanhua Tang, Jinqing Pan, Jiamei Han, Ming Cai, Huijun Zhang, Hong
Published in
BMC Anesthesiology
BackgroundStress response always occurs in cardiac valve replacement patients undergoing cardiopulmonary bypass (CPB).Methods60 patients undergoing cardiac valve replacement were recruited and randomized into control and Dex groups. Dex group received 1.0 μg·kg-1 of Dex for 10 min intravenously before anesthesia, followed by 0.5 μg·kg-1·h-1 of Dex,...
He, G Li, Q Li, W Ruan, Y Xiong, X Song, X Zeng, F
Published in
Herz
Our aim was to evaluate the effect of urinary trypsin inhibitors (UTI) on interleukin, tumor necrosis factor-α (TNF-α), and polymorphonuclear neutrophil elastase (PMNE) levels as well as on pulmonary function in patients undergoing cardiopulmonary bypass. We searched the following databases for relevant studies: PubMed, Medline (Ovid SP), Cochrane ...
Wang, Lei Chen, Qiang Qiu, Yong Qiang Ye, Jian Xi Du, Jian Zhi Lv, Xiao Chai Hou, Yan Ting Chen, Liang Wan
Published in
Journal of Cardiothoracic Surgery
BackgroundCardiopulmonary bypass (CPB) with high-priming volume can significantly activate the inflammatory response and increse the usage of packed red blood cells (PRBCs). As risks and complications related to transfusions are increasing, many cardiac centers are focusing on reducing the priming volume of CPB. In our center, efforts have also bee...
Fudulu, Daniel Paul Angelini, Gianni Davide Papadopoulou, Fani Fanoula Evans, Jonathan Walker-Smith, Terrie Kema, Ido Van Fassen, Martijn Stoica, Serban Caputo, Massimo Lightman, Stafford
...
Published in
BMC Cardiovascular Disorders
BackgroundCortisol is the main stress hormone mobilised during surgery to establish homeostasis. Our current understanding of the hypothalamic-pituitary-adrenal axis physiology in children undergoing cardiopulmonary bypass is very limited due to: (1) very few cortisol time point measurements over long periods (2) difficulties of sampling in low wei...
