Prasatthong, Patoomporn Meephat, Sariya Rattanakanokchai, Siwayu Bunbupha, Sarawoot Prachaney, Parichat Maneesai, Putcharawipa Pakdeechote, Poungrat
Published in
European journal of nutrition
Hesperidin has been reported to have biological activities such as antihypertensive, hypoglycemic, and antioxidant effects. This study investigated whether hesperidin could improve signs of the metabolic syndrome and cardiac function in a high-fat diet (HFD) induced metabolic syndrome (MS) in rats. Male Sprague-Dawley rats were fed HFD and 15% fruc...
Li, Yutian Deng, Shan Wang, Xiaohong Huang, Wei Chen, Jing Robbins, Nathan Mu, Xingjiang Essandoh, Kobina Peng, Tianqing Jegga, Anil G
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Published in
Cardiovascular research
Cardiac dysfunction is a prevalent comorbidity of disrupted inflammatory homeostasis observed in conditions such as sepsis (acute) or obesity (chronic). Secreted and transmembrane protein 1a (Sectm1a) has previously been implicated to regulate inflammatory responses, yet its role in inflammation-associated cardiac dysfunction is virtually unknown. ...
Heinen, Andre Gödecke, Stefanie Flögel, Ulrich Miklos, Dominika Bottermann, Katharina Spychala, André Gödecke, Axel
Published in
Basic Research in Cardiology
Conditional, cell-type-specific transgenic mouse lines are of high value in cardiovascular research. A standard tool for cardiomyocyte-restricted DNA editing is the αMHC-MerCreMer/loxP system. However, there is an ongoing debate on the occurrence of cardiac side effects caused by unspecific Cre activity or related to tamoxifen/oil overload. Here, w...
Venkat, Poornima Cui, Chengcheng Chen, Zhili Chopp, Michael Zacharek, Alex Landschoot-Ward, Julie Culmone, Lauren Yang, Xiao-Ping Xu, Jiang Chen, Jieli
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Published in
Translational stroke research
Cardiac complications post-stroke are common, and diabetes exacerbates post-stroke cardiac injury. In this study, we tested whether treatment with exosomes harvested from human umbilical cord blood derived CD133+ cells (CD133+Exo) improves cardiac function in type 2 diabetes mellitus (T2DM) stroke mice. Adult (3-4 m), male, BKS.Cg-m+/+Leprdb/J (db/...
Hu, Ying Qi, Fan-xing Yu, Li-na Geng, Wei
Published in
Pakistan Journal of Medical Sciences
Objectives: To investigate the effects of etibatide combined with emergency percutaneous coronary intervention (PCI) on blood perfusion and cardiac function in acute myocardial infarction (AMI) patients. Methods: This was a prospective, randomized, controlled study. From November 2015 to June 2019, 196 patients with ST-segment elevation myocardial ...
Moreno, Angel Kowalik, Grant Mendelowitz, David Kay, Matthew W
Published in
Methods in molecular biology (Clifton, N.J.)
Optogenetic technology has enabled unparalleled insights into cellular and organ physiology by providing exquisite temporal and spatial control of biological pathways. Here, an optogenetic approach is presented for selective activation of the intrinsic cardiac nervous system in excised perfused mouse hearts. The breeding of transgenic mice that hav...
Grandperrin, Antoine
Ces dernières années, la pratique de la musculation s’est largement démocratisée et regroupe aujourd’hui différents types de pratiquants, allant de la personne sédentaire en reprise d’activité au sportif de haut niveau pratiquant le culturisme. L’objectif de ces travaux de thèse a été d’étudier l’impact cardiaque de l’entraînement en musculation ch...
Groehs, Raphaela V Negrao, Marcelo V Hajjar, Ludhmila A Jordão, Camila P Carvalho, Bruna P Toschi-Dias, Edgar Andrade, Ana C Hodas, Fabiana P Alves, Maria J N N Sarmento, Adriana O
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Published in
The oncologist
Adjuvant chemotherapy with 5-fluorouracil (5-FU) and oxaliplatin increases recurrence-free and overall survival in patients with colon adenocarcinoma. It is known that these drugs have been associated with cardio- and neurotoxicity. We investigated the effects of 5-FU ± oxaliplatin on cardiac function, vascular responses, neurovascular control, and...
Rath, Dominik Petersen-Uribe, Álvaro Avdiu, Alban Witzel, Katja Jaeger, Philippa Zdanyte, Monika Heinzmann, David Tavlaki, Elli Müller, Karin Gawaz, Meinrad Paul
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Published in
Clinical research in cardiology : official journal of the German Cardiac Society
COVID-19 infection may cause severe respiratory distress and is associated with increased morbidity and mortality. Impaired cardiac function and/or pre-existing cardiovascular disease may be associated with poor prognosis. In the present study, we report a comprehensive cardiovascular characterization in the first consecutive collective of patients...
Iwano, Hiroyuki Shibayama, Kentaro Kitai, Takeshi Kusunose, Kenya Onishi, Tetsuari Tanaka, Hidekazu Anzai, Toshihisa
Published in
Journal of echocardiography
Early worsening heart failure (WHF), defined as worsening of symptoms and signs of heart failure requiring intensification of medical or mechanical therapy during an admission for acute decompensated heart failure (ADHF), has recently been recognized as a risk of morbidity or mortality after the discharge. Although echocardiographic parameters of l...