Moreno, Angel Kowalik, Grant Mendelowitz, David Kay, Matthew W
Published in
Methods in molecular biology (Clifton, N.J.)
Optogenetic technology has enabled unparalleled insights into cellular and organ physiology by providing exquisite temporal and spatial control of biological pathways. Here, an optogenetic approach is presented for selective activation of the intrinsic cardiac nervous system in excised perfused mouse hearts. The breeding of transgenic mice that hav...
Rath, Dominik Petersen-Uribe, Álvaro Avdiu, Alban Witzel, Katja Jaeger, Philippa Zdanyte, Monika Heinzmann, David Tavlaki, Elli Müller, Karin Gawaz, Meinrad Paul
...
Published in
Clinical research in cardiology : official journal of the German Cardiac Society
COVID-19 infection may cause severe respiratory distress and is associated with increased morbidity and mortality. Impaired cardiac function and/or pre-existing cardiovascular disease may be associated with poor prognosis. In the present study, we report a comprehensive cardiovascular characterization in the first consecutive collective of patients...
Iwano, Hiroyuki Shibayama, Kentaro Kitai, Takeshi Kusunose, Kenya Onishi, Tetsuari Tanaka, Hidekazu Anzai, Toshihisa
Published in
Journal of echocardiography
Early worsening heart failure (WHF), defined as worsening of symptoms and signs of heart failure requiring intensification of medical or mechanical therapy during an admission for acute decompensated heart failure (ADHF), has recently been recognized as a risk of morbidity or mortality after the discharge. Although echocardiographic parameters of l...
Feng, Qiuting Li, Xing Qin, Xian Yu, Cheng Jin, Yan Qian, Xiaojun
Published in
Molecular Medicine
BackgroundMyocardial infarction (MI) is the leading cause of death from cardiovascular disease (CVD). Currently, the efficacy for MI treatment remains unsatisfactory. Therefore, it is urgent to develop a novel therapeutic strategy.MethodsLeft anterior descending arteries (LAD) of mice were ligated to induce MI. Another set of mice were intravenousl...
Wolf, Annemarie Kutsche, Hanna Sarah Schreckenberg, Rolf Weber, Martin Li, Ling Rohrbach, Susanne Schulz, Rainer Schlüter, Klaus-Dieter
Published in
Basic Research in Cardiology
Proprotein convertase subtilisin kexin type 9 (PCSK9) is in the focus of cardiovascular research due to its role in hepatic low density lipoprotein (LDL) clearance. However, extrahepatic expression of PCSK9 such as in cardiomyocytes and its regulation by oxidized LDL (oxLDL) put notion on extrahepatic effects of PCSK9 as well. This study was aimed ...
Vargas, Emily A Patel, Ravi B Medina-Lezama, Josefina Chirinos, Diana A
Published in
International journal of behavioral medicine
Depressive symptoms are common among patients with heart failure and are often associated with adverse outcomes, including re-hospitalization and mortality. However, little is known about the association between depressive symptoms and subclinical markers of heart failure and cardiac function in community-based samples and little research has focus...
Fahmey, Sameh S Hodeib, Mahmoud Refaat, Khaled Mohammed, Walaa
Published in
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Background: Neonatal sepsis is an important cause of neonatal morbidity and mortality especially in developing countries. Cardiac dysfunction is a major complication of severe sepsis and occurs as a part of multiple organ failure.Objective: To asses right and left ventricular functions in neonates with sepsis using tissue Doppler imaging (TDI).Meth...
Ibrahim, El-Sayed H Baruah, Dhiraj Budde, Matthew Rubenstein, Jason Frei, Anne Schlaak, Rachel Gore, Elizabeth Bergom, Carmen
Published in
Magnetic resonance imaging
Cardiac MRI of small animal models of cancer radiation therapy (RT) is a valuable tool for studying the effect of RT on the heart. However, standard cardiac MRI exams require long scanning times, which is challenging for sick animals that may not survive extended periods of imaging under anesthesia. The purpose of this study is to develop an optimi...
Bai, Xiao-Jie Hao, Jun-Tao Zheng, Rong-Hua Yan, Cai-Ping Wang, Jin Yang, Cai-Hong Zhang, Wei-Fang Zhao, Zhi-Qing
Published in
Cardiovascular drugs and therapy
This study aimed to investigate whether inhibition of glucagon-like peptide-1 (GLP-1) on pressure overload induced cardiac hypertrophy and apoptosis is related to activation of ATP sensitive potassium (KATP) channels. Male SD rats were randomly divided into five groups: sham, control (abdominal aortic constriction), GLP-1 analog liraglutide (0.3 mg...
Zheng, Rong-Hua Zhang, Wei-Wei Ji, Ye-Nan Bai, Xiao-Jie Yan, Cai-Ping Wang, Jin Bai, Feng Zhao, Zhi-Qing
Published in
European journal of pharmacology
Mammalian target of rapamycin (mTOR) and a ribosomal protein S6 kinase (p70S6K) mediate tissue fibrosis and negatively regulate autophagy. This study aims to investigate whether glucagon-like peptide-1 (GLP-1) analog liraglutide protects the heart against aortic banding-induced cardiac fibrosis and dysfunction through inhibiting mTOR/p70S6K signali...