Wurster, Sebastian Lyos, Sebastian Albert, Nathaniel D Kontoyiannis, Dimitrios P
Published in
Medical mycology
Vasopressors are frequently given in hemodynamically unstable patients with severe Candida sepsis. While catecholamines can aggravate sepsis-induced immune dysfunction and modulate bacterial virulence traits, their impact on fungal pathogenicity is poorly understood. Using IncuCyte time-lapse microscopy and a fruit fly candidiasis model, we studied...
Niemiec, Stephen M Louiselle, Amanda E Liechty, Kenneth W Zgheib, Carlos
Published in
International journal of molecular sciences
Pressure ulcers are preventable, yet highly prevalent, chronic wounds that have significant patient morbidity and high healthcare costs. Like other chronic wounds, they are characterized by impaired wound healing due to dysregulated immune processes. This review will highlight key biochemical pathways in the pathogenesis of pressure injury and how ...
Gao, Shanjun Liu, Guangzhi Li, Jianguo Chen, Jing Li, Lina Li, Zhen Zhang, Xiulei Zhang, Shoumin Thorne, Rick Francis Zhang, Shuzhen
...
Published in
Frontiers in Cellular and Infection Microbiology
Compared to mono-species biofilm, biofilms formed by cross-kingdom pathogens are more refractory to conventional antibiotics, thus complicating clinical treatment and causing significant morbidity. Lemongrass essential oil and its bioactive component citral were previously demonstrated to possess strong antimicrobial efficacy against pathogenic bac...
Dumortier, Corentin Charlet, Rogatien Bettaieb, Ali Jawhara, Samir
Published in
Microorganisms
Deregulation of the dynamic crosstalk between the gut microbiota, intestinal epithelial cells, and immune cells is critically involved in the development of inflammatory bowel disease and the overgrowth of opportunistic pathogens, including the human opportunistic fungus Candida albicans . In the present study, we assessed the effect of N-[2-(p-bro...
Bernard, Clément Juin, Camille Vitry, Marine Le, Van Thanh Danh Verdon, Julien Toullec, Anne-Solène Imbert, Christine Girardot, Marion
Published in
Pharmaceuticals
Candida albicans is an opportunistic pathogen involved in many infections, especially linked to implanted medical devices. Its ability to form biofilms complicates the treatment of these infections as few molecules are active against sessile C. albicans . The aim of this study was to evaluate the potential of leaves, three-month-old and one-year-ol...
El-Batal, Ahmed I Abd Elkodous, M El-Sayyad, Gharieb S Al-Hazmi, Nawal E Gobara, Mohamed Baraka, Ahmad
Published in
International journal of biological macromolecules
In this research, irradiation by gamma rays was employed as an eco-friendly route for the construction of bimetallic silver-gold nanoparticles (Ag-Au NPs), while Gum Arabic polymer was used as a capping agent. Ag-Au NPs were characterized through UV-Vis., XRD, EDX, HR-TEM, FTIR, SEM/mapping and EDX analysis. Antibiofilm and antimicrobial activities...
Nguyen, Nu Z. N. Tran, Vuvi G. Lee, Saerom Kim, Minji Kang, Sang W. Kim, Juyang Kim, Hye J. Lee, Jong S. Cho, Hong R. Kwon, Byungsuk
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Published in
Immune Network
C-C chemokine receptor type 5 (CCR5) regulates the trafficking of various immune cells to sites of infection. In this study, we showed that expression of CCR5 and its ligands was rapidly increased in the kidney after systemic Candida albicans infection, and infected CCR5−/− mice exhibited increased mortality and morbidity, indicating that CCR5 cont...
Peng, Xueling Yu, Qilin Liu, Yingzheng Ma, Tianyu Li, Mingchun
Published in
Frontiers in Microbiology
In Saccharomyces cerevisiae , inositol polyphosphate kinase KCS1 but not VIP1 knockout is of great significance for maintaining cell viability, promoting glycolysis metabolism, and inducing mitochondrial damage. The functions of Candida albicans inositol polyphosphate kinases Kcs1 and Vip1 have not yet been studied. In this study, we found that the...
Herrero-de-Dios, Carmen Román, Elvira Pla, Jesús Alonso-Monge, Rebeca
Published in
Journal of Fungi
As opportunistic pathogen, Candida albicans adapts to different environmental conditions and its corresponding stress. The Hog1 MAPK (Mitogen Activated Protein Kinase) was identified as the main MAPK involved in the response to osmotic stress. It was later shown that this MAPK is also involved in the response to a variety of stresses and therefore,...
Yang, Mabel Walpole, Glenn F.W. Westman, Johannes
Published in
Microbial Cell
Professional phagocytes represent a critical node in innate immunity and tissue homeostasis through their specialized ability to eat, drink, and digest material from the extracellular milieu. The degradative and microbicidal functions of phagocytes rely on the fusion of lysosomes with endosomal compartments such as phagosomes, resulting in the dige...
