Saleem, Hiba Muwafaq Ramaiah, Pushpamala Gupta, Jitendra Jalil, Abduladheem Turki Kadhim, Noor Abdulaala Alsaikhan, Fahad Ramírez-Coronel, Andrés Alexis Tayyib, Nahla A Guo, Qingdong
Published in
Environmental research
Lung cancer is one of the leading causes of death in both males and females, and it is the first causes of cancer-related deaths. Chemotherapy, surgery and radiotherapy are conventional treatment of lung cancer and recently, immunotherapy has been also appeared as another therapeutic strategy for lung tumor. However, since previous treatments have ...
Margadant, Coert
Published in
Methods in molecular biology (Clifton, N.J.)
Cell migration plays an essential role in many pathophysiological processes, including embryonic development, wound healing, immunity, and cancer invasion, and is therefore a widely studied phenomenon in many different fields from basic cell biology to regenerative medicine. During the past decades, a multitude of increasingly complex methods have ...
Zhang, Jian Reinhart-King, Cynthia A
Published in
Methods in molecular biology (Clifton, N.J.)
Many solid tumors can invade the surrounding three-dimensional (3D) tissue in a collective manner, and increasing evidence suggests that collective migration makes cancer cell clusters more invasive and metastatic than individual cells. A cohesive cohort of cancer cells can have many advantages over individual cells, including more efficient bioene...
Jeong, Bo Young Cho, Kyung Hwa Jeong, Kang Jin Cho, Su Jin Won, Minho Kim, Seung Hwa Cho, Nam Hoon Hur, Gang Min Yoon, Se-Hee Park, Hwan-Woo
...
Published in
Cancer letters
Cancer-associated fibroblasts (CAFs) are key structural components of the tumor microenvironment and are closely associated with tumor invasion and metastasis. Lysophosphatidic acid (LPA) is a biolipid produced extracellularly and involved in tumorigenesis and metastasis. LPA has recently been implicated in the education and transdifferentiation of...
Jacques, Cécile
In the pre-invasive stage, the tumor is separated from the adjacent stroma by the basement membrane. Just beneath it, there is a network of cancer-associated fibroblasts (CAFs), the major producers and remodelers of the extracellular matrix (ECM). By enveloping tumors, CAFs create a physical barrier that prevents cancer cell invasion. However, CAFs...
Zhou, Jiamin Sun, Xianglin Zhang, Xinyu Yang, Huan Jiang, Zhenglin Luo, Qianqian Liu, Yifei Wang, Guohua
Published in
BMC cancer
As a metastasis-related protein, NEDD9 has been reported in breast cancer (BC) metastasis research. However, there are few studies on the upstream regulators of NEDD9, especially involving the potential role of miRNAs. The purpose of this study was to explain whether miR-107 potentially regulates NEDD9, which may lead to invasion and metastasis of ...
Gifford, Valentina Woskowicz, Anna Ito, Noriko Balint, Stefan Lagerholm, B Christopher Dustin, Michael L Itoh, Yoshifumi
Published in
Matrix biology : journal of the International Society for Matrix Biology
MT1-MMP plays a crucial role in promoting the cellular invasion of cancer cells by degrading the extracellular matrix to create a path for migration. During this process, its localization at the leading edge of migrating cells is critical, and it is achieved by targeted transport of MT1-MMP-containing vesicles along microtubules by kinesin superfam...
Weiss, Felix Atlasy, Nader van Reijmersdal, Vince Stunnenberg, Henk Hulsbergen-Veelken, Cornelia Friedl, Peter
Published in
In Vitro Models
3D in vitro culture models of cancer cells in extracellular matrix (ECM) have been developed to investigate drug targeting and resistance or, alternatively, mechanisms of invasion; however, models allowing analysis of shared pathways mediating invasion and therapy resistance are lacking. To evaluate therapy response associated with cancer cell inva...
Weiss, Felix Atlasy, Nader van Reijmersdal, Vince Stunnenberg, Henk Hulsbergen-Veelken, Cornelia Friedl, Peter
UNLABELLED: 3D in vitro culture models of cancer cells in extracellular matrix (ECM) have been developed to investigate drug targeting and resistance or, alternatively, mechanisms of invasion; however, models allowing analysis of shared pathways mediating invasion and therapy resistance are lacking. To evaluate therapy response associated with canc...
Barai, Amlan Mukherjee, Abhishek Das, Alakesh Saxena, Neha Sen, Shamik
Published in
Journal of cell science
The mechanisms by which the mechanoresponsive actin crosslinking protein α-actinin-4 (ACTN4) regulates cell motility and invasiveness remain incompletely understood. Here, we show that, in addition to regulating protrusion dynamics and focal adhesion formation, ACTN4 transcriptionally regulates expression of non-muscle myosin IIB (NMM IIB; heavy ch...
