Xie, Xiaoxue Feng, Yi Zhang, Hanxi Su, Qingqing Song, Ting Yang, Geng Li, Ningxi Wei, Xiaodan Li, Tingting Qin, Xiang
...
Published in
Bioactive materials
The clinical outcomes of cancer nanovaccine have been largely impeded owing to the low antigen-specific T cell response rate and acquired resistance caused by the immunosuppressive tumor microenvironment (TME). Here, we reported a tumor acidity-responsive nanovaccine to remodel the immunosuppressive TME and expand the recruitment of tumor infiltrat...
Soleimani, Neda Javadi, Mahtab Moshref
Published in
Microbial pathogenesis
Cancer, as a disease characterized by uncontrolled growth of cells, is recognized as one of the significant challenges in the field of health and medicine. There are various treatments for cancer like surgery, hormone therapy, chemotherapy, etc., but they have negative effects on the patient's lifestyle. Numerous side effects, and recently the emer...
Jiang, Han Fu, Hao Guo, Yuedong Hu, Ping Shi, Jianlin
Published in
Biomaterials
Immunogenic cell death (ICD) based on endoplasmic reticulum (ER) stress has been widely studied as the fundamentals of cancer immunotherapy. However, the currently available ICD inducers are still very rare and mostly highly toxic chemotherapeutic drugs. Herein, a novel ICD modality based on mitochondrial heat stress by magnetic hyperthermia treatm...
Griffin, Matthew E Hang, Howard C
The human microbiota acts as a diverse source of molecular cues that influence the development and homeostasis of the immune system. Beyond endogenous roles in the human holobiont, host-microbial interactions also alter outcomes for immune-related diseases and treatment regimens. Over the past decade, sequencing analyses of cancer patients have rev...
Huang, Fang Li, Zhichao Zhang, Wenhao Li, Jiaqi Hao, Siguo
Published in
Cancer immunology, immunotherapy : CII
Cell-released nanovesicles can induce anti-leukemia immunity. Leukemia cell-derived exosomes (LEXs) are promising anti-tumor vaccine components for cancer immunotherapy. Nonetheless, LEX-based vaccines show modest potency in vivo, likely due to the presence of immunosuppressive PD-L1 proteins in the exosomes. We hypothesized that targeting exosomal...
Cheng, Emily M Tsarovsky, Noah W Sondel, Paul M Rakhmilevich, Alexander L
Published in
Cancer immunology, immunotherapy : CII
Interleukin-12 (IL-12) is a type I cytokine involved in both innate and adaptive immunity that stimulates T and natural killer cell activity and induces interferon gamma production. IL-12 has been identified as a potential immunotherapeutic component for combinatorial cancer treatments. While IL-12 has successfully been used to treat a variety of c...
Kim, Hana Ahn, Soomin Kim, Hongsik Hong, Jung Yong Lee, Jeeyun Park, Se Hoon Park, Joon Oh Park, Young Suk Lim, Ho Yeong Kang, Won Ki
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Published in
Journal of cancer research and clinical oncology
Homologous recombination deficiency (HRD) is related to tumorigenesis. Currently, the possibility of HRD as a prognostic biomarker to immune checkpoint inhibitors is unknown. We aimed to investigate whether HRD has potential as a biomarker for immunotherapy. The status of homologous recombination deficiency (HRD) was assessed with the next-generati...
Njonkou, Rosy Jackson, Christopher M Woodworth, Graeme F Hersh, David S
Published in
Cancer immunology, immunotherapy : CII
Pediatric glioblastoma is relatively rare compared with its adult counterpart but is associated with a similarly grim prognosis. Available data indicate that pediatric glioblastomas are molecularly distinct from adult tumors, and relatively little is known about the pediatric glioblastoma tumor microenvironment (TME). Cancer immunotherapy has emerg...
Chaganty, Bharat K R Qiu, Songbo Lu, Yang Lopez-Berestein, Gabriel Ozpolat, Bulent Fan, Zhen
Published in
Cancer immunology, immunotherapy : CII
We tested the concept that host preexisting influenza A virus immunity can be redirected to inhibit tumor growth and metastasis through systemic administration of influenza A virus-related peptides to targeted tumors. Mice infected with influenza A virus strain A/Puerto Rico/8/34 (PR8) were used as a model of a host with preexisting viral immunity....
Sun, Qi Xiao, Lin Cui, Zhiying Yang, Yaping Ma, Junting Huang, Zhen Zhang, Junfeng Chen, Jiangning
Published in
Chinese medicine
Immune checkpoint inhibitors that target programmed cell death protein 1 (PD-1) have obtained encouraging results, but a fraction of tumor patients failed to respond to anti-PD-1 treatment due to the existence of multiple immune suppressive elements such as myeloid-derived suppressor cells (MDSCs). Traditional Chinese medicine or natural products f...
