Nevens, Daan Jongen, Aurélien Kindts, Isabelle Billiet, Charlotte Deseyne, Pieter Joye, Ines Lievens, Yolande Guckenberger, Matthias
Published in
International journal of radiation oncology, biology, physics
There is increasing evidence for the integration of locally ablative therapy into multimodality treatment of oligometastatic disease (OMD). To support standardised data collection, analysis, and comparison, a consensus OMD classification based on fundamental disease and treatment characteristics has previously been established. This study investiga...
Infante, Maria Stefania Salmanton-García, Jon Fernández-Cruz, Ana Marchesi, Francesco Jaksic, Ozren Weinbergerová, Barbora Besson, Caroline Duarte, Rafael F. Itri, Federico Valković, Toni
...
Published in
Frontiers in Oncology
Patients with lymphoproliferative diseases (LPD) are vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Here, we describe and analyze the outcome of 366 adult patients with chronic lymphocytic leukemia (CLL) or non-Hodgkin Lymphoma (NHL) treated with targeted drugs and laboratory-confirmed COVID-19 diagnosed betwe...
Dubois, Nadège Berendsen, Sharon Tan, Katherine Schoysmans, Laurent Spliet, Wim Seute, Tatjana Bours, Vincent Robe, Pierre
peer reviewed / The copy number and mRNA expression of STAT5b were assessed in samples from the TCGA repository of glioblastomas (GBM). The activation of this transcription factor was analyzed on tissue microarrays comprising 392 WHO 2016 GBM samples from our clinical practice. These data were correlated with patient survival using multivariable Co...
tulkens;, dieter
Modeling human genetic diseases and cancer in lab animals has been greatly aided by the emergence of genetic engineering tools such as TALENs and CRISPR/Cas9. We have previously demonstrated the ease with which genetically engineered Xenopus models (GEXM) can be generated via injection of early embryos with Cas9 recombinant protein loaded with sgRN...
a., tatiana
Glioma is the most common brain tumor, for which no significant improvement in life expectancy and quality of life is yet possible. The creation of stable fluorescent glioma cell lines is a promising tool for in-depth studies of the molecular mechanisms of glioma initialization and pathogenesis, as well as for the development of new anti-cancer str...
Feng, Panpan Chen, Dawei Wang, Xia Li, Yanxia Li, Zhenyu Li, Boya Zhang, Yupeng Li, Wei Zhang, Jingru Ye, Jingjing
...
peer reviewed / T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignant leukemia with extremely limited treatment for relapsed patients. N6-methyladenosine (m6A) reader insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) participates in the initiation and growth of cancers by communicating with various targets. Here, we fou...
Oltean, Teodora Lippens, Lien Lemeire, Kelly De Tender, Caroline Vuylsteke, Marnik Denys, Hannelore Vandecasteele, Katrien Vandenabeele, Peter Adjemian, Sandy
Published in
Frontiers in Oncology
Irradiation induces distinct cellular responses such as apoptosis, necroptosis, iron-dependent cell death (a feature of ferroptosis), senescence, and mitotic catastrophe. Several of these outcomes are immunostimulatory and may represent a potential for immunogenic type of cell death (ICD) induced by radiotherapy triggering abscopal effects. The pur...
De Groef, An Demeyer, Heleen de Kinkelder, Carlijn Dukers-van Althuis, Sanne Asnong, Anne Dams, Lore Van der Gucht, Elien De Vrieze, Tessa Haenen, Vincent Evenepoel, Margaux
...
Published in
Clinical breast cancer
We hypothesize that prediagnosis physical activity (PA) levels of breast cancer patients are below those of a reference population without breast cancer. Therefore, the aim of the present study was to compare prediagnosis PA levels (including total-, occupational-, sport- and household activity levels) of breast cancer patients with activity levels...
Dodkins, Joanna Hopman, Wilma M Wells, John Connor Lievens, Yolande Malik, R A Pramesh, C S Gyawali, Bishal Hammad, Nazik Mukherji, Deborah Sullivan, Richard
...
Published in
International journal of radiation oncology, biology, physics
Randomized controlled trials (RCTs) are the cornerstone of delivering sustained improvements in cancer outcome. To inform radiation therapy research policy and prioritization, we analyze the radiation therapy RCT landscape including comparison with trials of systemic therapies over the same period, with a specific focus on funding and disparities a...
Chargari, Cyrus Haie-Meder, Christine Espenel, Sophie Garcia, Max-Adrien Ben-Arush, Myriam Bolle, Stéphanie Borjesson, Anna Cesen, Maja Lago, Rita Costa Defachelles, Anne-Sophie
...
Published in
International journal of radiation oncology, biology, physics
Childhood cancer is rare, and treatment is frequently associated with long-term morbidity. Disparities in survival and long-term side effects encourage the establishment of networks to increase access to complex organ-conservative strategies, such as brachytherapy. We report our experience of an international cooperation model in childhood cancers....
