Alzeibak, Razan Mishchenko, Tatiana A. Shilyagina, Natalia Y. Balalaeva, Irina V. Vedunova, Maria V. Krysko, Dmitri V.
Published in
Journal for Immunotherapy of Cancer
The past decade has witnessed major breakthroughs in cancer immunotherapy. This development has been largely motivated by cancer cell evasion of immunological control and consequent tumor resistance to conventional therapies. Immunogenic cell death (ICD) is considered one of the most promising ways to achieve total tumor cell elimination. It activa...
Claeys, Arne Luijts, Tom Marchal, Kathleen Van den Eynden, Jimmy
Cancer is driven by somatic mutations that result in a cellular fitness advantage. This selective advantage is expected to be counterbalanced by the immune system when these driver mutations simultaneously lead to the generation of neoantigens, novel peptides that are presented at the cancer cell membrane via HLA molecules from the MHC complex. The...
Loontiens, Siebe Vanhauwaert, Suzanne Depestel, Lisa Dewyn, Givani Van Loocke, Wouter Moore, Finola E Garcia, Elaine G Batchelor, Lance Borga, Chiara Squiban, Barbara
...
Published in
Leukemia
Clarisse, Dorien Offner, Fritz De Bosscher, Karolien
Published in
Biochimica et biophysica acta. Reviews on cancer
Glucocorticoids are essential drugs in the treatment protocols of lymphoid malignancies. These steroidal hormones trigger apoptosis of the malignant cells by binding to the glucocorticoid receptor (GR), which is a member of the nuclear receptor superfamily. Long term glucocorticoid treatment is limited by two major problems: the development of gluc...
Tajchman, Katarzyna Ukalska-Jaruga, Aleksandra Bogdaszewski, Marek Pecio, Monika Dziki-Michalska, Katarzyna
Published in
Animals : an open access journal from MDPI
The aim of the study was to determine the concentrations of toxic elements accumulated in the bone marrow and bones (Cervus elaphus). The studies were carried out on two groups of young stags: farmed (n = 6) and wild (n = 9). Their body weights were measured and bone and bone marrow samples were collected. The concentrations of toxic elements were ...
Ghirotto, Luca De Panfilis, Ludovica Di Leo, Silvia
Published in
BMC Medical Education
BackgroundThe interest for qualitative research methodology has expanded beyond theoretical academic research on medical education, gathering interest from all healthcare professionals. Qualitative research has potentials in exploring the social, emotional, psychological aspects of care and in broadening professionals’ scientific competencies. None...
Lieverse, Relinde I. Y. Van Limbergen, Evert J. Oberije, Cary J. G. Troost, Esther G. C. Hadrup, Sine R. Dingemans, Anne-Marie C. Hendriks, Lizza E. L. Eckert, Franziska Hiley, Crispin Dooms, Christophe
...
Published in
BMC Cancer
BackgroundAbout 50% of non-small cell lung cancer (NSCLC) patients have metastatic disease at initial diagnosis, which limits their treatment options and, consequently, the 5-year survival rate (15%). Immune checkpoint inhibitors (ICI), either alone or in combination with chemotherapy, have become standard of care (SOC) for most good performance st...
Snowden, Austyn Young, Jenny Savinc, Jan
Published in
BMC Cancer
BackgroundCancer impacts on patients and their families across a range of different domains. For that reason, optimal cancer care has moved away from a disease-centric focus to a more holistic approach in order to proactively support people with their individual needs and concerns. While international policy clearly advocates this agenda, implement...
Velanis, Christos N Perera, Pumi Thomson, Bennett de Leau, Erica Liang, Shih Chieh Hartwig, Ben Förderer, Alexander Thornton, Harry Arede, Pedro Chen, Jiawen
...
Published in
PLoS genetics
A large fraction of plant genomes is composed of transposable elements (TE), which provide a potential source of novel genes through "domestication"-the process whereby the proteins encoded by TE diverge in sequence, lose their ability to catalyse transposition and instead acquire novel functions for their hosts. In Arabidopsis, ANTAGONIST OF LIKE ...
LIEVENS, YOLANDE Borras, Josep M. Grau, Cai
Radiation therapy is one of the core components of multidisciplinary cancer care. Although similar to 50% of all European cancer patients have an indication for radiotherapy at least once in the course of their disease, more than one out of four cancer patients in Europe do not receive the radiotherapy they need. There are multiple reasons for this...