Alsuliman, Tamim Aubrun, Clotilde Bay, Jacques Olivier Beguin, Yves Bigenwald, Camille Brissot, Eolia Chalandon, Yves Chevallier, Patrice Pagliuca, Simona Magro, Léonardo
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peer reviewed / Chimeric antigen receptor T cell (CAR-T cell) therapy has become a standard-of-care for several hematological and a promising treatment for solid malignancies or for selected non-malignant autoimmune disorders. Hematological complications following this treatment are very common with the majority of patients experiencing at least on...
LEJEUNE, Marie Menard, Bertille Servais, Sophie ANDRIANNE, Christelle Capelle, Lucie De Maistre, Ségolène Fabaron, Catherine Cornier, Marie Flata Goutagny, Marie-Pierre Pereira, Maguy
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peer reviewed / Haematopoietic stem cell collection from paediatric donors is a common and life-saving practice, as evidenced by the fact that there is a growing annual number of cases of transplants from minor donors among SFGM-TC centers over the last decade. Still, medical use of human tissue from a healthy and underage donor requires proper reg...
Yan, Pengze Jimenez, Ernesto Rojas Li, Zheqi Bui, Triet Seehawer, Marco Nishida, Jun Foidart, Pierre Stevens, Laura E Xie, Yingtian Gomez, Miguel Munoz
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peer reviewed / Aging is a pivotal risk factor for cancer, yet the underlying mechanisms remain poorly defined. Here, we explore age-related changes in the rat mammary gland by single-cell multiomics. Our findings include increased epithelial proliferation, loss of luminal identity, and decreased naive B and T cells with age. We discover a luminal ...
Roth, Patrick Gorlia, Thierry Reijneveld, Jaap C de Vos, Filip Idbaih, Ahmed Frenel, Jean-Sébastien Le Rhun, Emilie Sepulveda, Juan Manuel Perry, James Masucci, G Laura
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peer reviewed / [en] BACKGROUND: Standard treatment for patients with newly diagnosed glioblastoma includes surgery, radiotherapy (RT), and temozolomide (TMZ) chemotherapy (TMZ/RT→TMZ). The proteasome has long been considered a promising therapeutic target because of its role as a central biological hub in tumor cells. Marizomib is a novel pan-prot...
Jones, Christine M Ciubotariu, Ilinca I Gebhardt, Mary E Lupiya, James Sichivula Mbewe, David Muleba, Mbanga Stevenson, Jennifer C Norris, Douglas E
Published in
Insects
In the global fight against malaria, standard vector control methods such as indoor residual spraying (IRS) and insecticide-treated nets (ITNs) are intended to protect inside residential structures and sleeping spaces. However, these methods can still leave individuals vulnerable to residual transmission from vectors that they may be exposed to out...
Rademakers, Timo Manca, Marco Jin, Han Orban, Tanguy Perisic, Ljubica Matic Frissen, Hubertus J M Rühle, Frank Hautvast, Petra van Rijssel, Jos van Kuijk, Kim
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peer reviewed / The presence of atherosclerotic plaque vessels is a critical factor in plaque destabilization. This may be attributable to the leaky phenotype of these microvessels, although direct proof for this notion is lacking. In this study, we investigated molecular and cellular patterns of stable and hemorrhaged human plaque to identify nove...
Sotelo, Juan G Bonilla-Ríos, Jaime Gordillo, José L
Published in
Sensors (Basel, Switzerland)
This research enhances ethanol sensing with Fe-doped tetragonal SnO2 films on glass, improving gas sensor reliability and sensitivity. The primary objective was to improve the sensitivity and operational efficiency of SnO2 sensors through Fe doping. The SnO2 sensors were synthesized using a flexible and adaptable method that allows for precise dopi...
Lee, Robert J Adappa, Nithin D Palmer, James N
Published in
Cells
Akt is an important kinase in metabolism. Akt also phosphorylates and activates endothelial and neuronal nitric oxide (NO) synthases (eNOS and nNOS, respectively) expressed in M0 (unpolarized) macrophages. We showed that e/nNOS NO production downstream of bitter taste receptors enhances macrophage phagocytosis. In airway epithelial cells, we also s...
Seifert, Marietta Leszczynska, Barbara Gemming, Thomas
Published in
Materials (Basel, Switzerland)
The high-temperature stability of RuAl-based electrodes for application in microelectronic devices is analyzed for long-term duration. The electrodes are prepared on Ca3TaGa3Si2O14 (CTGS) substrates using SiO2 and Al-N-O cover and barrier layers as oxidation protection. The samples are annealed at 600, 700, or 800 °C in air for 192 h. Minor degrada...
Blondeau, Joseph M Fitch, Shantelle D
Published in
Pathogens (Basel, Switzerland)
Pradofloxacin-a dual-targeting fluoroquinolone-is the most recent approved for use in food animals. Minimum inhibitory and mutant prevention concentration values were determined for pradofloxacin, ceftiofur, enrofloxacin, florfenicol, marbofloxacin, tildipirosin, tilmicosin, and tulathromycin. For M. haemolytica strains, MIC50/90/100 values were ≤0...