von der Grün, Jens; https://orcid.org/00... Ahmadsei, Maiwand Breyer, Isabel Britschgi, Christian; https://orcid.org/... Eberli, Daniel; https://orcid.org/0000-0... Hermanns, Thomas Mangana, Joanna Petrowsky, Henrik; https://orcid.org/000... Ramelyte, Egle; https://orcid.org/0000-0... Roth, Patrick
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Background and purpose: To analyze clinical trial activities and patient recruitment numbers into prospective clinical studies for solid malignancies during the COVID-19 pandemic in a tertiary cancer center. Materials and methods: Patient recruitment numbers in prospective clinical studies of solid malignancies were retrospectively analyzed for the...
Tahri, Safaa Texier, Blanche Nunes, Jean-Claude Hemon, Cédric Lekieffre, Pauline Collot, Emma Chourak, Hilda Le Guevelou, Jennifer Greer, Peter Dowling, Jason
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Introduction: For radiotherapy based solely on magnetic resonance imaging (MRI), generating synthetic computed tomography scans (sCT) from MRI is essential for dose calculation. The use of deep learning (DL) methods to generate sCT from MRI has shown encouraging results if the MRI images used for training the deep learning network and the MRI image...
Saouli, Amine Ruffion, Alain Dariane, Charles Barret, Eric Fiard, Gaëlle Fromont-Hankard, Gaëlle Roubaud, Guilhem Beauval, Jean Baptiste Brureau, L Renard-Penna, Raphaelle
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The aim of this study was to systematically review the current evidence regarding oncological and functional outcomes salvage radical prostatectomy (sRP) for recurrent prostate cancer. A systematic conducted throughout September 2022 using PubMed, Science Direct, Scopus, Embase databases. Preferred Reporting Items Systematic Reviews Meta-analysis (...
Hamza, Abderaouf Masliah-Planchon, Julien Neuzillet, Cindy Svrcek, Magali Vacher, Sophie Bourneix, Christine Delaye, Matthieu Goéré, Diane Dartigues, Peggy Samalin, Emmanuelle
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The management of anal squamous cell carcinoma (ASCC) has yet to experience the transformative impact of precision medicine. Conducting genomic analyses may uncover novel prognostic biomarkers and offer potential directions for the development of targeted therapies. To that end, we assessed the prognostic and theragnostic implications of pathogenic...
Knowles, Thomas C Summerton, Anna G Whiting, James G H Pearson, Martin J
Published in
Biomimetics (Basel, Switzerland)
The ability to navigate effectively in a rich and complex world is crucial for the survival of all animals. Specialist neural structures have evolved that are implicated in facilitating this ability, one such structure being the ring attractor network. In this study, we model a trio of Spiking Neural Network (SNN) ring attractors as part of a bio-i...
Vergote, Ignace Van Nieuwenhuysen, Els O'Cearbhaill, Roisin E Westermann, Anneke Lorusso, Domenica Ghamande, Sharad Collins, Dearbhaile C Banerjee, Susana Mathews, Cara A Gennigens, Christine
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peer reviewed / [en] PURPOSE: Tissue factor is highly expressed in cervical carcinoma and can be targeted by tisotumab vedotin (TV), an antibody-drug conjugate. This phase Ib/II study evaluated TV in combination with bevacizumab, pembrolizumab, or carboplatin for recurrent or metastatic cervical cancer (r/mCC). METHODS: This open-label, multicenter...
Kunke, Madlen Knöfler, Hannah Dahlke, Eileen Zanon Rodriguez, Luis Böttner, Martina Larionov, Alexey Saudenova, Makhabbat Ohrenschall, Gerrit M Westermann, Magdalena Porubsky, Stefan
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peer reviewed / Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease. Glomerular hyperfiltration and albuminuria subject the proximal tubule (PT) to a subsequent elevation of workload, growth, and hypoxia. Hypoxia plays an ambiguous role in the development and progression of DKD and shall be clarified in our study. PT-von-H...
De Bousser, Elien Callewaert, Nico Festjens, Nele
Published in
Cancers
In the past decade, chimeric antigen receptor (CAR) T cell technology has revolutionized cancer immunotherapy. This strategy uses synthetic CARs to redirect the patient's own immune cells to recognize specific antigens expressed on the surface of tumor cells. The unprecedented success of anti-CD19 CAR T cell therapy against B cell malignancies has ...
Cui, Xia Xu, Lei Qi, Kezhen Lan, Hai
Published in
Molecules (Basel, Switzerland)
In order to investigate the antibacterial mechanism of tea polyphenols and theaflavins against oral cariogenic bacteria, the pH value of the culture medium, the number of bacteria adhering to the smooth glass tube wall, and the electrical conductivity value within 10 h were measured, respectively. The effects of four concentrations of tea polypheno...
Purdy, Sarah Deberker, David
Published in
BMJ clinical evidence
Acne vulgaris affects over 80% of teenagers, and persists beyond the age of 25 years in 3% of men and 12% of women. Typical lesions of acne include comedones, inflammatory papules, and pustules. Nodules and cysts occur in more severe acne and can cause scarring and psychological distress. We conducted a systematic review and aimed to answer the fol...