Wild, Sophia A Cannell, Ian G Nicholls, Ashley Kania, Katarzyna Bressan, Dario Hannon, Gregory J Sawicka, Kirsty
Tumour heterogeneity is thought to be a major barrier to successful cancer treatment due to the presence of drug resistant clonal lineages. However, identifying the characteristics of such lineages that underpin resistance to therapy has remained challenging. Here, we utilise clonal transcriptomics with WILD-seq; Wholistic Interrogation of Lineage ...
Wild, Sophia A Cannell, Ian G Nicholls, Ashley Kania, Katarzyna Bressan, Dario imaxt, cruk Hannon, Gregory J Sawicka, Kirsty
Peer reviewed: True / Tumour heterogeneity is thought to be a major barrier to successful cancer treatment due to the presence of drug resistant clonal lineages. However, identifying the characteristics of such lineages that underpin resistance to therapy has remained challenging. Here, we utilise clonal transcriptomics with WILD-seq; Wholistic Int...
Spears, Meghan E.
Sphingolipids are a class of lipid molecules that function both as structural membrane components and as bioactive signaling molecules. Sphingolipids can be produced de novo or salvaged and recycled. Despite the established roles of sphingolipids such as sphingosine 1-phosphate and ceramides in regulating signaling involved in pro- and anti-tumorig...
Dang, Kyvan
Hippo signaling is a tumor suppressive signaling pathway that controls organ size by regulating cellular proliferation, apoptosis, and differentiation during development, regeneration, and homeostasis. The Hippo pathway inhibits transcriptional co-activators and Hippo pathway effectors YAP/TAZ, activation of which is often seen in cancer. Within th...
Cong, Ke
Mutations in the hereditary breast/ovarian cancer genes BRCA1/2 were shown to be synthetic lethal with poly(ADP-ribose) polymerase inhibitors (PARPi). This toxicity is assumed to derive from PARPi-induced DNA double strand breaks (DSBs) that necessitate BRCA function in homologous recombination (HR) and/or fork protection (FP). However, PARPi accel...
Rajkumar, Utkrisht Chennanchetty
Deep learning methods have significantly advanced the state of computer vision and natural language processing. Their ability to discover intricate patterns in ever-expanding datasets is critical in solving cancer biology problems. However, cancer biology poses unique challenges. Typical input data, such as tumor images and DNA sequences, have sign...
Knight, John Rp Vlahov, Nikola Gay, David M Ridgway, Rachel A Faller, William James Proud, Christopher Mallucci, Giovanna R von der Haar, Tobias Smales, Christopher Mark Willis, Anne E
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Funder: National Health and Medical Research Council / Increased protein synthesis supports the rapid cell proliferation associated with cancer. The Rpl24Bst mutant mouse reduces the expression of the ribosomal protein RPL24 and has been used to suppress translation and limit tumorigenesis in multiple mouse models of cancer. Here, we show that Rpl2...
Drljača, Branko Savović, Svetislav Kovačević, Milan S Simović, Ana Kuzmanović, Ljubica Djordjevich, Alexandar Min, Rui
Published in
Polymers
By solving the time-dependent power flow equation, we present a novel approach for evaluating the bandwidth in a multimode step-index polymer photonic crystal fiber (SI PPCF) with a solid core. The bandwidth of such fiber is determined for various layouts of air holes and widths of Gaussian launch beam distribution. We found that the lower the NA o...
Beyaz, Semir Chung, Charlie Mou, Haiwei Bauer-Rowe, Khristian E. Xifaras, Michael E. Ergin, Ilgin Dohnalova, Lenka Biton, Moshe Shekhar, Karthik Eskiocak, Onur
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Little is known about how interactions of diet, intestinal stem cells (ISCs), and immune cells affect early-stage intestinal tumorigenesis. We show that a high-fat diet (HFD) reduces the expression of the major histocompatibility complex class II (MHC class II) genes in intestinal epithelial cells, including ISCs. This decline in epithelial MHC cla...
Rozen, Esteban Javier Shohet, Jason Matthew
BACKGROUND: Neuroblastoma is a devastating disease accounting for 15% of all childhood cancer deaths. Yet, our understanding of key molecular drivers such as receptor tyrosine kinases (RTKs) in this pathology remains poorly clarified. Here, we provide a systematic analysis of the RTK superfamily in the context of neuroblastoma pathogenesis. METHODS...