Gilson, Pauline Levy, Julien Rouyer, Marie Demange, Jessica Husson, Marie Bonnet, Céline Salleron, Julia Leroux, Agnès Merlin, Jean-Louis Harlé, Alexandre
...
Published in
Scientific Reports
Microsatellite instability (MSI) status is routinely assessed in patients with colorectal and endometrial cancers as it contributes to Lynch syndrome initial screening, tumour prognosis and selecting patients for immunotherapy. Currently, standard reference methods recommended for MSI/dMMR (deficient MisMatch Repair) testing consist of immunohistoc...
Silveira, Sandra Cunha Buhagiar-Labarchède, Géraldine Onclercq-Delic, Rosine Gemble, Simon Bou Samra, Elias Mameri, Hamza Duchambon, Patricia Machon, Christelle Guitton, Jérôme Amor-Guéret, Mounira
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Published in
Scientific Reports
Cytidine deaminase (CDA) deficiency causes pyrimidine pool disequilibrium. We previously reported that the excess cellular dC and dCTP resulting from CDA deficiency jeopardizes genome stability, decreasing basal poly(ADP-ribose) polymerase 1 (PARP-1) activity and increasing ultrafine anaphase bridge (UFB) formation. Here, we investigated the mechan...
Papadimitriou, Nikos Dimou, Niki Tsilidis, Konstantinos K. Banbury, Barbara Martin, Richard M. Lewis, Sarah J. Kazmi, Nabila Robinson, Timothy M. Albanes, Demetrius Aleksandrova, Krasimira
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Published in
Nature Communications
Physical activity has been linked to lower risks of colorectal and breast cancer. Here, the authors present a Mendelian randomisation analysis supporting a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer.
Rolver, Michala G. Elingaard-Larsen, Line O. Andersen, Anne P. Counillon, Laurent Pedersen, Stine F.
Published in
Scientific Reports
The Na+/H+ exchanger-1 (NHE1) supports tumour growth, making NHE1 inhibitors of interest in anticancer therapy, yet their molecular effects are incompletely characterized. Here, we demonstrate that widely used pyrazinoylguanidine-type NHE1 inhibitors potently inhibit growth and survival of cancer cell spheroids, in a manner unrelated to NHE1 inhibi...
Allenby, Taylor H Crenshaw, Megan L Mathis, Katlynn Champ, Colin E Simone, Nicole L Schmitz, Kathryn H Tchelebi, Leila T Zaorsky, Nicholas G
Published in
Technical innovations & patient support in radiation oncology
Our objectives are to assess (1) the acceptability and feasibility of dietary interventions for patients undergoing radiation therapy (RT), and (2) the impact of dietary interventions on patient reported outcomes, toxicities, and survival. A PICOS/PRISMA/MOOSE selection protocol was used to include articles that evaluate adding dietary intervention...
Liu, Shiyang Harmston, Nathan Glaser, Trudy Lee Wong, Yunka Zhong, Zheng Madan, Babita Virshup, David M. Petretto, Enrico
Published in
Genome Medicine
Background Wnt signaling is an evolutionarily conserved developmental pathway that is frequently hyperactivated in cancer. While multiple protein-coding genes regulated by Wnt signaling are known, the functional lncRNAs regulated by Wnt signaling have not been systematically characterized. Methods We comprehensively mapped Wnt-regulated lncRNAs fro...
Rodin, Danielle Lovas, Mike Berlin, Alejandro
Published in
Healthcare (Amsterdam, Netherlands)
There has been longstanding interest in virtual care in oncology, but outdated reimbursement structures and a paradoxical lack of agility within electronic systems limited widespread adoption. Through the example of the Province of Ontario, Canada and the Princess Margaret Cancer Centre, we describe how a collective sense of action from COVID-19, a...
Moody, Laura Chen, Hong Pan, Yuan-Xiang
Published in
BMC Medical Genomics
Background Advancements in transcriptomic profiling have led to the emergence of new challenges regarding data integration and interpretability. Variability between measurement platforms makes it difficult to compare between cohorts, and large numbers of gene features have encouraged the use black box methods that are not easily translated into bio...
Uzan-Yulzari, Atara Morr, Maya Tareef-Nabwani, Hala Ziv, Oren Magid-Neriya, Dafna Armoni, Ran Muller, Efrat Leibovici, Anca Borenstein, Elhanan Louzoun, Yoram
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Published in
BMC Medicine
Background Adjuvant chemotherapy induces weight gain, glucose intolerance, and hypertension in about a third of women. The mechanisms underlying these events have not been defined. This study assessed the association between the microbiome and weight gain in patients treated with adjuvant chemotherapy for breast and gynecological cancers. Methods P...
Li, Xiaomin Gou, Junhe Li, Hongjiang Yang, Xiaoqin
Published in
Scientific Reports
Chromobox (CBX) family proteins control chromatin structure and gene expression. However, the functions of CBXs in cancer progression, especially breast cancer, are inadequately studied. We assessed the significance of eight CBX proteins in breast cancer. We performed immunohistochemistry and bioinformatic analysis of data from Oncomine, GEPIA Data...
