Vigoda, Myles Mathieson, Chase Evans, Nathaniel Hale, Carolyn Jennings, Jennifer Lucero, Olivia Jeng, Sophia Bottomly, Daniel Clayburgh, Daniel Andersen, Peter
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Published in
Cancer biology & therapy
In this study, we report a differential response of mitogen-activated protein kinase-kinase (MEK) inhibitor trametinib in 20 head and neck squamous cell carcinoma (HNSCC) patients' tumor-derived cell cultures. Relatively sensitive and resistant cases to trametinib were identified using high throughput metabolic assays and validated in extended dose...
Allende-Vega, Nerea Marco Brualla, Joaquin Falvo, Paolo Alexia, Catherine Constantinides, Michael de Maudave, Alexis Fayd’herbe Coenon, Lois Gitenay, Delphine Mitola, Giulia Massa, Paul
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Published in
Scientific Reports
Solid tumor cells have an altered metabolism that can protect them from cytotoxic lymphocytes. The anti-diabetic drug metformin modifies tumor cell metabolism and several clinical trials are testing its effectiveness for the treatment of solid cancers. The use of metformin in hematologic cancers has received much less attention, although allogeneic...
Grant, Michael Hockings, Helen Lapuente, Maria Adeniran, Philip Saud, Rabiah Abbas Sivajothi, Anjali Amin, Jubel Crusz, Shanthini M Rashid, Sukaina Szabados, Bernadette
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Published in
Journal of cancer education : the official journal of the American Association for Cancer Education
The COVID-19 pandemic has necessitated adaptation of cancer patient care. Oncology patients who contract COVID-19 have poor outcomes. Telemedicine clinics (teleclinics) have been introduced for cancer patients to reduce the risk of horizontal transmission at St. Bartholomew's Hospital and The Royal Free Hospital in London. Teleclinics have become r...
Kciuk, Mateusz Gielecińska, Adrianna Mujwar, Somdutt Mojzych, Mariusz Marciniak, Beata Drozda, Rafał Kontek, Renata
Published in
Journal of enzyme inhibition and medicinal chemistry
Carbonic anhydrases IX and CAXII (CAIX/CAXII) are transmembrane zinc metalloproteins that catalyze a very basic but crucial physiological reaction: the conversion of carbon dioxide into bicarbonate with a release of the proton. CA, especially CAIX and CAXII isoforms gained the attention of many researchers interested in anticancer drug design due t...
Belkahla, Sana Brualla, Joaquin Marco Fayd’herbe de Maudave, Alexis Falvo, Paolo Allende-Vega, Nerea Constantinides, Michael Khan, Abrar Ul Haq Coenon, Lois Alexia, Catherine Mitola, Giulia
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Published in
Scientific Reports
Leukemic cells proliferate faster than non-transformed counterparts. This requires them to change their metabolism to adapt to their high growth. This change can stress cells and facilitate recognition by immune cells such as cytotoxic lymphocytes, which express the activating receptor Natural Killer G2-D (NKG2D). The tumor suppressor gene p53 regu...
Yazici, Hilmi Eren, Ayse Uprak, Tevfik Kivilcim Sahan, Cihan Esmer, Ahmet Cem Yegen, Sevket Cumhur
Published in
Journal of gastrointestinal cancer
From the early days of 2020, the COVID-19 pandemic continues to change whole life all around the world. Oncological patients are the most affected populations since these days. Because of decreasing numbers in surgery and endoscopy, gastric cancer patients had difficulties in treatment and diagnoses. Therefore, the early and long-term results may b...
Bertho, S Neyroud, A S Brun, T Jaillard, S Bonnet, F Ravel, C
Published in
Morphologie : bulletin de l'Association des anatomistes
The anti-Müllerian hormone (AMH) is a heterodimeric glycoprotein belonging to the TGFb superfamily implicated in human embryonic development. This hormone was first described as allowing regression of the epithelial embryonic Müllerian structures in males, which would otherwise differentiate into the uterus and fallopian tubes. It activates a signa...
Van Trigt, William K Kelly, Kristen M Hughes, Christopher CW
Port-wine birthmarks (PWBs) are caused by somatic, mosaic mutations in the G protein guanine nucleotide binding protein alpha subunit q (GNAQ) and are characterized by the formation of dilated, dysfunctional blood vessels in the dermis, eyes, and/or brain. Cutaneous PWBs can be treated by current dermatologic therapy, like laser intervention, to li...
Geiss, Carley Chavez, Melody N Oswald, Laura B Ketcher, Dana Reblin, Maija Bandera, Elisa V Savard, Josée Zhou, Eric S Fox, Rina S Jim, Heather S L
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Published in
Annals of behavioral medicine : a publication of the Society of Behavioral Medicine
Sleep disturbance is common and distressing among cancer survivors. Black breast cancer survivors (BBCS) suffer disproportionately from sleep disturbance, yet there is limited research on how to address this issue. This study aimed to understand the multifaceted experiences of sleep disturbance among BBCS and how to culturally target a mobile healt...
Malcomson, Fiona C. Willis, Naomi D. Mathers, John C.
Published in
Frontiers for Young Minds
Lifestyle—what we eat, how much exercise we do, and how much we weigh, can change our chances of getting diseases like cancer in the large intestine (colorectal cancer). The World Cancer Research Fund has come up with eight lifestyle recommendations to lower our chances of getting cancer. For example, we are recommended to eat at least five serving...
