Mendes, Joseane A. Eduardo Salustiano Pires, Carulini de S. Oliveira, Thaís Barcellos, Julio C.F. Cifuentes, Jhonny M.C. Costa, Paulo R.R. Rennó, Magdalena N. Buarque, Camilla D.
Published in
Bioorganic Chemistry
11a-N-tosyl-5-carbapterocarpans (5a–c and 6a–c), 9-N-tosyl-4,4a,9,9a-tetrahydro-3H-carbazole (7), 11a-N-tosyl-5-carbapterocarpen (8) analogues of LQB-223 (4a), were synthesized through palladium catalyzedazaarylation of substituted dihydronaphtalenes (14a–c) and cyclohexadiene (15), respectively, with N-tosyl-o-iodoaniline ( 11). In order to unders...
El Alaoui-Lasmaili, Karima Faivre, Béatrice
Currently in cancer treatment, one premise is to use antiangiogenic therapies in association with chemotherapy or radiotherapy to augment their efficacy by benefiting from the vascular “normalization” induced by antiangiogenic therapy. This concept defines the time during which the tumor blood vessels adopt normal-like morphology and functionality,...
El Alaoui-Lasmaili, Karima Faivre, Béatrice
Currently in cancer treatment, one premise is to use antiangiogenic therapies in association with chemotherapy or radiotherapy to augment their efficacy by benefiting from the vascular “normalization” induced by antiangiogenic therapy. This concept defines the time during which the tumor blood vessels adopt normal-like morphology and functionality,...
El Alaoui-Lasmaili, Karima Faivre, Béatrice
Currently in cancer treatment, one premise is to use antiangiogenic therapies in association with chemotherapy or radiotherapy to augment their efficacy by benefiting from the vascular “normalization” induced by antiangiogenic therapy. This concept defines the time during which the tumor blood vessels adopt normal-like morphology and functionality,...
El Alaoui-Lasmaili, Karima Faivre, Béatrice
Currently in cancer treatment, one premise is to use antiangiogenic therapies in association with chemotherapy or radiotherapy to augment their efficacy by benefiting from the vascular “normalization” induced by antiangiogenic therapy. This concept defines the time during which the tumor blood vessels adopt normal-like morphology and functionality,...
El Alaoui-Lasmaili, Karima Faivre, Béatrice
Currently in cancer treatment, one premise is to use antiangiogenic therapies in association with chemotherapy or radiotherapy to augment their efficacy by benefiting from the vascular “normalization” induced by antiangiogenic therapy. This concept defines the time during which the tumor blood vessels adopt normal-like morphology and functionality,...
Xue, Zhuyi Warren, René L Gibb, Ewan A MacMillan, Daniel Wong, Johnathan Chiu, Readman Hammond, S. Austin Yang, Chen Nip, Ka M Ennis, Catherine A
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Faculty
Poret, Benjamin
La surexpression de récepteurs couplés aux protéines G (RCPG) dans certains cancers est mise à profit en médecine nucléaire pour développer des radioligands capables de diagnostiquer la présence de tumeurs. A titre d’exemple, des analogues de la somatostatine marqués à l’indium-111 (111In-OctreoScan) sont utilisés pour le diagnostic de tumeurs neur...
Poret, Benjamin
La surexpression de récepteurs couplés aux protéines G (RCPG) dans certains cancers est mise à profit en médecine nucléaire pour développer des radioligands capables de diagnostiquer la présence de tumeurs. A titre d’exemple, des analogues de la somatostatine marqués à l’indium-111 (111In-OctreoScan) sont utilisés pour le diagnostic de tumeurs neur...
Rapino, Francesca Delaunay, Sylvain Rambow, Florian Zhou, Zhaoli Tharun, Lars De Tullio, Pascal Sin, Olga Shostak, Kateryna Schmitz, Sebastian Piepers, Jolanda
...
Reprogramming of mRNA translation has a key role in cancer development and drug resistance. However, the molecular mechanisms that are involved in this process remain poorly understood. Wobble tRNA modifications are required for specific codon decoding during translation. Here we show, in humans, that the enzymes that catalyse modifications of wobb...
