Zhao, Tingting Li, Xuening Chen, Yanwei Du, Jie Chen, Xiaodong Wang, Dalong Wang, Liyan Zhao, Shan Wang, Changyuan Meng, Qiang
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Published in
Frontiers in Pharmacology
Cancer patients generally has a high risk of thrombotic diseases. However, anticoagulant therapy always aggravates bleeding risks. Rivaroxaban is one of the most widely used direct oral anticoagulants, which is used as anticoagulant treatment or prophylaxis in clinical practice. The present study aimed to systemically estimate the combination safet...
Zhao, Tingting Chen, Yanwei Wang, Dalong Wang, Liyan Dong, Peipei Zhao, Shan Wang, Changyuan Meng, Qiang Sun, Huijun Liu, Kexin
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Published in
Cardiovascular drugs and therapy
Rivaroxaban, an oral anticoagulant, undergoes the metabolism mediated by human cytochrome P450 (CYP). The present study is to quantitatively analyze and compare the contributions of multiple CYPs in the metabolism of rivaroxaban to provide new information for medication safety. The metabolic stability of rivaroxaban in the presence of human liver m...
Gui, Liang Chen, Youlu Diao, Yongpeng Chen, Zuoguan Duan, Jianwei Liang, Xiaoyu Li, Huiyang Liu, Kaijing Miao, Yuqing Gao, Qing
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Published in
Materials today. Bio
With critical limb ischemia (CLI) being a multi-factorial disease, it is becoming evident that gene therapy with a multiple bio-functional growth factor could achieve better therapeutic outcomes. Cytochrome P450 epoxygenase-2J2 (CYP2J2) and its catalytic products epoxyeicosatrienoic acids (EETs) exhibit pleiotropic biological activities, including ...
Zhang, Jing Xiong, Qi Yang, Lin Xue, Yanni Ke, Min Li, Zhi
Published in
Bioengineered
Retinopathy of Prematurity (ROP), a type of retinal neovascularization in premature infants, has become a serious problem that drastically affects the quality of life of premature infants. ROP is associated with angiogenesis and neovascularization. Here, we aimed to explain the function and latent roles of Cytochrome P450 2J2 (CYP2J2) in hypoxia-in...
Ding, Yun Tu, Pengjie Chen, Yiyong Huang, Yangyun Pan, Xiaojie Chen, Wenshu
Published in
Respiratory Research
BackgroundCytochrome P450 epoxygenase 2J2 (CYP2J2) metabolizes arachidonic acid to epoxyeicosatrienoic acids (EETs), which exert anti-inflammatory, anti-apoptotic, pro-proliferative, and antioxidant effects on the cardiovascular system. However, the role of CYP2J2 and EETs in pulmonary arterial hypertension (PAH) with lung ischemia–reperfusion inju...
Li, Haiyue He, Yongjun Wang, Li Xing, Shishi Peng, Linna Yuan, Dongya Jin, Tianbo
Published in
American Journal of Translational Research
Genetic characteristics of CYP2J2 in different populations may be helpful to explore interethnic variability in drug response and disease susceptibility. There is no information about the genetic profile of CYP2J2 in the Chinese Uyghur population. We used PCR and first-generation sequencing technology to investigate CYP2J2 mutations in 100 unrelate...
Tian, Xiangge Zhou, Meirong Ning, Jing Deng, Xiaopeng Feng, Lei Huang, Huilian Yao, Dahong Ma, Xiaochi
Published in
Journal of Enzyme Inhibition and Medicinal Chemistry
Gui, Liang Xu, Qiang Huang, Juju Wu, Gaojue Tang, Hong Hui, Li Hua, Ping Zhang, Lili Zhu, Yingwei
Published in
American Journal of Translational Research
Objective: This study aimed to explore the function and mechanism of Cytochrome P450 2J2 (CYP2J2) epoxygenase and epoxyeicosatrienoic acids (EETs) in the malignant development of hepatocellular carcinoma (HCC). Method: The expressional levels of EETs and CYP2J2 in HCC tissues and cell lines were quantified by ELISA, western blot and RT-qPCR, respec...
Lei, Xuejiao Chen, Xuezhu Quan, Yulian Tao, Yihao Li, Junlong
Published in
Frontiers in Oncology
Enhancing the therapeutic efficacy of anti-tumor drugs is essential for cancer management. Although cannabinoid receptor 2 (CB2R) stimulation exerts anti-tumor action in glioma cells by regulating cellular proliferation, differentiation, or apoptosis, selective CB2R agonist alone does not achieve a satisfactory therapeutic outcome. Herein, we aimed...
Habieb, Mona S Dawood, Ashraf A Emara, Mahmoud M Elhelbawy, Mohammad G Elhelbawy, Nesreen G
Published in
The Application of Clinical Genetics
Background Diabetic nephropathy (DN), the primary driver of end-stage kidney disease, is a problem with serious consequences for society’s health. Single nucleotide polymorphisms (SNPs) can define differences in susceptibility to DN and aid in development of personalized treatment. Giving the importance of epoxyeicosatrienoic acids (EETs) in kidney...
