Park, Sungyeon Kang, Minsoo Kim, Suhyun An, Hyoung-Tae Gettemans, Jan Ko, Jesang
Published in
Frontiers in Cell and Developmental Biology
The first-line treatment for prostate cancer (PCa) is androgen ablation therapy. However, prostate tumors generally recur and progress to androgen-independent PCa (AIPC) within 2–3 years. α-Actinin-4 (ACTN4) is an actin-binding protein that belongs to the spectrin gene superfamily and acts as an oncogene in various cancer types. Although ACTN4 is i...
Bonnefont, Jerome; Tiberi, Luca; van den Ameele, Jelle; Potier, Delphine; Gaber, Zachary B; Lin, Xionghui; Bilheu, Angeline; Herpoel, Adele; Bravo, Fausto D Velez; Guillemot, Francois;
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During neurogenesis, progenitors switch from self-renewal to differentiation through the interplay of intrinsic and extrinsic cues, but how these are integrated remains poorly understood. Here, we combine whole-genome transcriptional and epigenetic analyses with in vivo functional studies to demonstrate that Bcl6, a transcriptional repressor previo...
Gul, Anita Leyland-Jones, Brain Dey, Nandini De, Pradip
Published in
American Journal of Cancer Research
Cyclin-dependent kinase 4 (CDK4) and CDK6 together with D-type cyclins (D1, D2 and D3) to promote cell cycle entry and progression through G1 by inactivating retinoblastoma protein (RB) by inhibiting an INK4 family of CDK inhibitors (CDKN2A/B). Selective cyclin-dependent kinase inhibitors are game changers in the clinical management of hormone rece...
Zan, Peng-Fei Yao, Jie Wu, Zhong Yang, Yong Hu, Shuo Li, Guo-Dong
Published in
Journal of cellular biochemistry
This study investigated the effects of cyclin D1 gene silencing on cell proliferation and apoptosis of interleukin-1β (IL-1β)-induced osteoarthritis (OA) chondrocytes. Chondrocytes from healthy sprague-dawley rats were divided into blank, OA model (chondrocytes underwent IL-1β inducement), OA trial (chondrocytes underwent IL-1β inducement with cycl...
Cuppens, Tine Annibali, Daniela Coosemans, An Trovik, Jone ter Haar, Natalja Colas, Eva Garcia-Jimenez, Angel Van de Vijver, Koen Kruitwagen, Roy PM Brinkhuis, Mariel
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Kuroda, Kengo Kiyono, Tohru Eitsuka, Takahiro Isogai, Hiroshi Takahashi, Koichi Donai, Kenichiro Isogai, Emiko Fukuda, Tomokazu
Published in
Journal of cellular biochemistry
Nonhuman primates are useful animal models for the study of human diseases. However, the number of established cell lines from nonhuman primates is quite limited compared with the number established from other experimental animals. The establishment of nonhuman primate cell lines would allow drug testing on those cell lines before moving experiment...
Kim, Myung-Hyun Ham, Onju Lee, Se-Yeon Choi, Eunmi Lee, Chang Youn Park, Jun-Hee Lee, Jiyun Seo, Hyang-Hee Seung, Minji Choi, Eunhyun
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Published in
Journal of cellular biochemistry
Abnormal proliferation of vascular smooth muscle cells (VSMCs) is a common feature of disease progression in atherosclerosis. Cell proliferation is regulated by cell cycle regulatory proteins. MicroRNAs (miR) have been reported to act as important gene regulators and play essential roles in the proliferation and migration of VSMCs in a cardiovascul...
Xiong, Cheng-Juan Li, Ping-Fa Song, Yang-Liu Xue, Li-Xiang Jia, Zhu-Qing Yao, Chun-Xia Wei, Qing-Xia Zhang, Shu-Feng Zhang, Shan-Feng Zhang, Yan-Yan
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Published in
Journal of cellular biochemistry
Insulin is a secreted peptide hormone identified in human pancreas to promote glucose utilization. Insulin has been observed to induce cell proliferation and myogenesis in C2C12 cells. The precise mechanisms underlying the proliferation of C2C12 cells induced by insulin remain unclear. In this study, we observed for the first time that 10 nM insuli...
Xavier, Flávia Caló de Aquino Rodini, Camila Oliveira Paiva, Katiucia Batista da Silva Souza Setubal Destro, Maria Fernanda Severino, Patricia Moyses, Raquel A. Tajara, Eloiza H. Nunes, Fabio Daumas
GENCAPO Consortium
Xavier, Flávia Caló de Aquino Rodini, Camila Oliveira Paiva, Katiucia Batista da Silva Souza Setubal Destro, Maria Fernanda Severino, Patricia Moyses, Raquel A. Tajara, Eloiza H. Nunes, Fabio Daumas
GENCAPO Consortium
