BACKGROUND: Appropriate-technology tests are needed for Mycobacterium tuberculosis drug-susceptibility testing (DST) in resource-constrained settings. We evaluated the MDR/XDRTB colour plate thin-layer agar test (TB-CX) for M. tuberculosis DST by directly testing sputum at University of Gondar Hospital. METHODS: Sputum samples were each divided int...
Published in Genome Biology
As genome-scale measurements lead to increasingly complex models of gene regulation, systematic approaches are needed to validate and refine these models. Towards this goal, we describe an automated procedure for prioritizing genetic perturbations in order to discriminate optimally between alternative models of a gene-regulatory network. Using this...
Two major challenges of 3D bioprinting are the retention of structural fidelity and efficient endothelialization for tissue vascularization. We address both of these issues by introducinga versatile3D bioprinting strategy, in which a templating bioink is deposited layer-by-layer alongside a matrix bioink to establish void-free multimaterial structu...
Comprehensive management of a severe diabetic foot infection focus on clear treatment pathways. Including rapid, radical debridement of all infection in addition to intravenous antibiotics and supportive measures. However, inexperienced surgeons can often underestimate the extent of infection, risking inadequate debridement, repeated theatre episod...
Un carnaval reggae dans les rues de Londres, un festival de théâtre en région parisienne, des concerts rock entre Paris et Londres contre le racisme et les violences policières dont sont victimes les populations immigrées… Au tournant des années 1960, les militants et les créateurs font de leur art l’instrument d’une vive dénonciation des condition...
В данной статье обосновывается подход к изучению культуры уральских марийцев как культуры регионально-этнического типа. Данный подход помогает выделить те факторы, которые влияют на трансформацию культуры, придают ей особый региональный колорит. / This article substantiates the approach of studying the culture of the Ural Mari people as a culture o...
Published in Stem Cell Research & Therapy
BackgroundSox2 is a well-established pluripotent transcription factor that plays an essential role in establishing and maintaining pluripotent stem cells (PSCs). It is also thought to be a linage specifier that governs PSC neural lineage specification upon their exiting the pluripotent state. However, the exact role of SOX2 in human PSCs was still ...
Национальная идея является одной из наиболее социально значимых проблем современной России. Отношение российских граждан к этому феномену неоднозначно есть сторонники, но немало и противников. Ещё больше граждан безразличных, не осознающих необходимость национальной идеи и не верящих в саму возможность её реального появления. Это объясняется против...
