Saketkoo, Lesley Ann Frech, Tracy Varjú, Cecília Domsic, Robyn Farrell, Jessica Gordon, Jessica K Mihai, Carina Sandorfi, Nora Shapiro, Lee Poole, Janet
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Published in
Best practice & research. Clinical rheumatology
Systemic sclerosis (SSc), the most lethal of rheumatologic conditions, is the cause of death in >50% of SSc cases, led by pulmonary fibrosis followed by pulmonary hypertension and then scleroderma renal crisis (SRC). Multiple other preventable and treatable SSc-related vascular, cardiac, gastrointestinal, nutritional and musculoskeletal complicatio...
Smith, Vanessa Herrick, Ariane L. Ingegnoli, Francesca Damjanov, Nemanja De Angelis, Rossella Denton, Christopher P. Distler, Oliver Espejo, Karinna Foeldvari, Ivan Frech, Tracy
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Capillaroscopy is a non-invasive and safe tool which allows the evaluation of the morphology of the microcirculation. Since its recent incorporation in the 2013 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria for systemic sclerosis together with its assessed role to monitor disease progressi...
Mihai, Carina Smith, Vanessa Dobrota, Rucsandra Gheorghiu, Ana Maria Cutolo, Maurizio Distler, Oliver
Published in
Microvascular research
Systemic sclerosis (SSc) is a connective tissue disease with high morbidity and mortality, characterized by autoimmunity, obliterative vasculopathy involving mainly the microvasculature, and fibrosis. SSc-specific nailfold capillaroscopic changes have been defined, and nailfold capillaroscopy (NFC) is now unequivocally accepted to be a cornerstone ...
Ruaro, Barbara Sulli, Alberto Smith, Vanessa Pizzorni, Carmen Paolino, Sabrina Alessandri, Elisa Trombetta, Amelia Chiara Cutolo, Maurizio
Published in
Journal of Scleroderma and Related Disorders
Systemic sclerosis is an autoimmune connective tissue disease characterized by early and persistent microvascular impairment which leads to functional and organic manifestations, with progressive fibrosis of the skin and internal organs. Morphological and functional assessment of the peripheral microvasculature is a must, not only for diagnosis but...
Cutolo, Maurizio Melsens, Karin Wijnant, Sara Ingegnoli, Francesca Thevissen, Kristof De Keyser, Filip Decuman, Saskia Müller-Ladner, Ulf Piette, Yves Riccieri, Valeria
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Ruaro, B Sulli, A Smith, V Pizzorni, C Paolino, S Alessandri, E Cutolo, M
Published in
Reumatismo
Microvascular damage and a decrease in peripheral blood perfusion are typical features of systemic sclerosis (SSc) with serious clinical implications, not only for a very early diagnosis, but also for disease progression. Nailfold videocapillaroscopy is a validated and safe imaging technique able to detect peripheral capillary morphology, as well a...
Jacob, Joseph Bartholmai, Brian J Rajagopalan, Srinivasan Egashira, Ryoko Brun, Anne Laure Kokosi, Maria Nair, Arjun Walsh, Simon L F Karwoski, Ronald Nicholson, Andrew G
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Published in
Respiratory medicine
Unclassifiable-interstitial lung disease (uILD) represents a heterogeneous collection of pathologies encompassing those fibrosing lung diseases which do not fulfill current diagnostic criteria. We evaluated baseline and longitudinal functional and CT (visual and quantitative computer [CALIPER] analysis) variables to identify outcome predictors in u...
Bertolazzi, Chiara Cutolo, Maurizio Smith, Vanessa Gutierrez, Marwin
Knobler, R Moinzadeh, P Hunzelmann, N Kreuter, A Cozzio, A Mouthon, L Cutolo, M Rongioletti, F Denton, CP Rudnicka, L
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The term 'sclerosing diseases of the skin' comprises specific dermatological entities, which have fibrotic changes of the skin in common. These diseases mostly manifest in different clinical subtypes according to cutaneous and extracutaneous involvement and can sometimes be difficult to distinguish from each other. The present guideline focuses on ...
Trombetta, Amelia Chiara Smith, Vanessa Pizzorni, Carmen Meroni, Marianna Paolino, Sabrina Cariti, Caterina Ruaro, Barbara Sulli, Alberto Cutolo, Maurizio
Published in
The Journal of rheumatology
To quantify earlier capillary diameter abnormalities, observed by nailfold videocapillaroscopy (NVC), in primary Raynaud phenomenon (PRP) subjects compared with RP subjects later evolved to systemic sclerosis (SSc)-associated secondary Raynaud phenomenon (SRP). There were 6112 NVC images of 191 subjects analyzed at baseline and after a mean followu...
