We describe a precision medicine workflow, the integrated single nucleotide polymorphism network platform (iSNP), designed to determine the mechanisms by which SNPs affect cellular regulatory networks, and how SNP co-occurrences contribute to disease pathogenesis in ulcerative colitis (UC). Using SNP profiles of 378 UC patients we map the regulator...
status: published
Psilocybin therapy shows antidepressant potential, but its therapeutic actions are not well understood. We assessed the sub-acute impact of psilocybin on brain function in two clinical trials of depression. The first was an open-label trial of orally administered psilocybin (10mg and 25mg, 7 days apart) in treatment-resistant depression (TRD). fMRI...
Although the amendment of various forms of exogenous organic matter (EOM) is a common practice in cropland production, it is to date not clear if its mineralisation in soil depends on application rate. Previous research suggested that spatial concentration of EOM in soil positively impacts its degradability. Here, we seek to test these reports and ...
The agglomeration of airports into multi-airport regions (MARs) has become one of the salient features of the worldwide air transport system in the last decades. Meanwhile, in China, the development of HSR is growing quickly, and is both competitive to and cooperative with the aviation network. To date some research has focused on the airport class...
Aim : This study aimed at investigating the taxonomic resolutions (TRs) of benthic macroinvertebrates for freshwater assessments in the scope of the functional trait approach (FTA). Location: Macroinvertebrate samples were collected in 22 locations within the Paute River Basin (PRB), Ecuador, over three years (2010, 2011 and 2012). Methods: Biologi...
Purpose Keystone taxa play an important role in soil nutrient cycling and crop growth and can be influenced by soil tillage. We investigated the composition of keystone taxa and their relationships with soil properties under different long-term tillage practices. Methods Four tillage treatments (i.e., CT, conventional tillage; NT, no tillage with m...
Bioremediation technology has attracted increasing interest due to it efficient, economical and eco-friendly to apply to heavy metal contaminated soil. This study presents a new biological remediation system with phosphate functionalized iron-based nanomaterials and phosphate solubilizing bacterium strain Leclercia adecarboxylata. Different phospha...
Bioremediation technology has attracted increasing interest due to it efficient, economical and eco-friendly to apply to heavy metal contaminated soil. This study presents a new biological remediation system with phosphate functionalized iron-based nanomaterials and phosphate solubilizing bacterium strain Leclercia adecarboxylata. Different phospha...
During the last few years, quinoa, a traditional Andean crop, has been cultivated at low elevations where pest pressure is high and farmers resort to intensive use of insecticides. This field study investigated the impact of four insecticides (cypermethrin, imidacloprid, teflubenzuron and emamectin benzoate) on insect pests of quinoa and their side...
