Disseminated histoplasmosis with central nervous system involvement in a kidney transplant recipient.
Published in Transplant infectious disease : an official journal of the Transplantation Society
Clodronate is not protective in lethal viral encephalitis despite substantially reducing inflammatory monocyte infiltrat...
Published in Frontiers in Immunology
Bone marrow (BM)-derived monocytes induce inflammation and tissue damage in a range of pathologies. In particular, in a mouse model of West Nile virus (WNV) encephalitis (WNE), nitric oxide-producing, Ly6Chi inflammatory monocytes from the BM are recruited to the central nervous system (CNS) and contribute to lethal immune pathology. Reducing the m...
Neuropathology in COVID-19 autopsies is defined by microglial activation and lesions of the white matter with emphasis i...
Published in Frontiers in Neurology
Introduction This study aimed to investigate microglial and macrophage activation in 17 patients who died in the context of a COVID-19 infection in 2020 and 2021. Methods Through immunohistochemical analysis, the lysosomal marker CD68 was used to detect diffuse parenchymal microglial activity, pronounced perivascular macrophage activation and macro...
Pro-inflammatory cytokine responses to Naegleria fowleri infection
Published in Frontiers in Tropical Diseases
Naegleria fowleri, or the “brain-eating amoeba,” is responsible for a rare, but lethal, infection known as primary amoebic meningoencephalitis (PAM). Confirmed PAM cases have seen both a rise in numbers, as well as expansion of geographic range over the past several decades. There is no effective therapy for PAM and the clinical prognosis remains g...
Viral infections in pediatric brain tumor patients treated with targeted therapies.
Published in Pediatric blood & cancer
Brain tumors are the most common solid malignancies and the leading cause of cancer-related mortality in children. While numerous studies report on viral infections in children with hematologic malignancies and solid organ transplantation, epidemiologic data on the incidence and outcome of viral infections in pediatric patients with brain tumors tr...
Multiplex detection of meningitis and encephalitis pathogens: A study from laboratory to clinic
Published in Frontiers in Neurology
Introduction Infectious meningitis and encephalitis (ME) are life-threatening conditions are caused by various pathogens. Conventional laboratory tests with low sensitivity and specificity cannot help with early diagnosis. Methods A prospective study using the novel multiplex PCR detection for 18 pathogens of ME (MME-18) was conducted to investigat...
Seizures in adults with suspected central nervous system infection.
Published in BMC neurology
Seizures can be part of the clinical presentation of central nervous system (CNS) infections. We describe patients suspected of a neurological infection who present with a seizure and study diagnostic accuracy of clinical and laboratory features predictive of CNS infection in this population. We analyzed all consecutive patients presenting with a s...
Analysing triggers for anti-NMDA-receptor encephalitis including herpes simplex virus encephalitis and ovarian teratoma:...
Published in Internal medicine journal
Anti-N-methyl-D-aspartate-receptor (anti-NMDA-R) encephalitis is a complex autoimmune neuropsychiatric syndrome. Although initially associated with ovarian teratoma, subsequent studies have demonstrated that anti-NMDA-R encephalitis may occur without an identifiable cause or be triggered by viral infection of the central nervous system such as herp...
Neurobrucellosis: report of 54 cases
Published in Tropical Medicine and Health
Background Brucellosis is among the most widespread zoonotic diseases worldwide. Although rare, nervous system involvement due to Brucella infection is a major diagnostic challenge in endemic regions. Patients and methods This study was a cross-sectional investigation of hospitalized adults with neurobrucellosis from March 2007 to February 2017. We...
Metagenomic next-generation sequencing of cell-free and whole-cell DNA in diagnosing central nervous system infections
...
Published in Frontiers in Cellular and Infection Microbiology
Background Central nervous system (CNS) infections pose a fatal risk to patients. However, the limited sample volumes of cerebrospinal fluid (CSF) and low detection efficiency seriously hinder the accurate detection of pathogens using conventional methods. Methods We evaluated the performance of metagenomics next-generation sequencing (mNGS) in dia...
