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Ou, Hong-Ling Wu, Hui Ren, Yu-Liang Si, Yuan Duan, Zhong-Qi Liu, Xue-Wen
Published in
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
This study aims to investigate the effect and mechanism of hydnocarpin(HC) in treating triple negative breast cancer(TNBC). Cell counting kit-8(CCK-8), xCELLigence real-time cellular analysis(RTCA), and colony formation assay were employed to determine the effects of HC on the proliferation of two TNBC cell lines: MDA-MB-231 and MDA-MB-436. The eff...
Tsuda, Masumi Noguchi, Misa Kurai, Tsuyoshi Ichihashi, Yuji Ise, Koki Wang, Lei Ishida, Yusuke Tanino, Mishie Hirano, Satoshi Asaka, Masahiro
...
Published in
Cancer science
In 2020, the worldwide incidence and mortality of colorectal cancer (CRC) were third and second, respectively. As the 5-y survival rate is low when CRC is diagnosed at an advanced stage, a reliable method to predict CRC susceptibility is important for preventing the onset and development and improving the prognosis of CRC. Therefore, we focused on ...
Zhang, Biao Han, Song Ma, Haitao Chen, Shaomu
Published in
FEBS open bio
The use of immune checkpoint inhibitors that target programmed cell death-1 (PD-1) has been proposed for the treatment of advanced non-small cell lung cancer (NSCLC). However, in clinical trials, cumulative response rates to anti-PD-1 treatment were approximately 20% in patients with NSCLC. CCR4-NOT transcription complex, subunit 4 (CNOT4) is a RIN...
Lopes, Fátima Torres, Fátima Lynch, Sally Ann Jorge, Arminda Sousa, Susana Silva, João Rendeiro, Paula Tavares, Purificação Fortuna, Ana Maria Maciel, Patrícia
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Published in
neurogenetics
Copy number variations (CNVs) at the 7q33 cytoband are very rarely described in the literature, and almost all of the cases comprise large deletions affecting more than just the q33 segment. We report seven patients (two families with two siblings and their affected mother and one unrelated patient) with neurodevelopmental delay associated with CNV...
Zhang, Li Tran, Ngoc-Tung Su, Hairui Wang, Rui Lu, Yuheng Tang, Haiping Aoyagi, Sayura Guo, Ailan Khodadadi-Jamayran, Alireza Zhou, Dewang
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Published in
eLife
RBM15, an RNA binding protein, determines cell-fate specification of many tissues including blood. We demonstrate that RBM15 is methylated by protein arginine methyltransferase 1 (PRMT1) at residue R578, leading to its degradation via ubiquitylation by an E3 ligase (CNOT4). Overexpression of PRMT1 in acute megakaryocytic leukemia cell lines blocks ...
