Advanced retinoblastoma (Rb) tumors display high metastatic spread to distant tissues, causing a potent threat to vision and life. Through transcriptomic profiling, we discovered key upregulated genes that belonged to the epithelial-mesenchymal transition (EMT) and chemotherapy resistance pathways in advanced Rb tumors. Through in vitro models, we ...
Salmonella enterica serovar Typhimurium causes a devastating burden of invasive disease in sub-Saharan Africa with high levels of antimicrobial resistance. No licensed vaccine is available, but O-antigen-based candidates are in development, as the O-antigen moiety of lipopolysaccharides is the principal target of protective immunity. The vaccines u...
Published in Journal of Bacteriology
The chemosensory signal transduction system Wsp regulates biofilm formation and related phenotypes by influencing cyclic-di-GMP (c-di-GMP) levels in bacterial cells. This is typically achieved by activation of the diguanylate cyclase WspR, through phosphorylation of its phosphoreceiver domain. The Wsp system of Burkholderia cenocepacia J2315 is in ...
Статья посвящена рассмотрению подходов к формированию модели экономического развития муниципального образования на основе создания территориального лесного кластера. Проанализированы преимущества и проблемные аспекты использования кластерного подхода организации экономической деятельности на уровне муниципального образования. На примере Ашинского р...
People in the southwestern (SW) coastal part of Bangladesh are suffering from a severe freshwater crisis due to saline groundwater at a shallow depth. Fresh groundwater below a 200 m depth is an option, but it is costly to construct deep tubewells for the local inhabitants. The processes of salinization and freshening were previously identified usi...
The development of spots or lesions symptomatic of common scab on root and tuber crops is caused by few pathogenic Streptomyces with Streptomyces scabiei 87-22 as the model species. Thaxtomin phytotoxins are the primary virulence determinants, mainly acting by impairing cellulose synthesis, and their production in S. scabiei is in turn boosted by c...
Multiscale simulations of fluidized beds should account for the effect of sub-grid structures on drag. How to extract the features of these structures in the form of proper finite quantities, namely markers, has posed great challenges in mesoscale drag modeling. The choice of markers has seldom been investigated in terms of their rationality and ad...
Multiscale simulations of fluidized beds should account for the effect of sub-grid structures on drag. How to extract the features of these structures in the form of proper finite quantities, namely markers, has posed great challenges in mesoscale drag modeling. The choice of markers has seldom been investigated in terms of their rationality and ad...
Published in The Astrophysical Journal
We present the H 160 morphological catalogs for the COSMOS-DASH survey, the largest area near-IR survey using HST-WFC3 to date. Utilizing the “Drift And SHift” observing technique for HST-WFC3 imaging, the COSMOS-DASH survey imaged approximately 0.5 deg2 of the UltraVISTA deep stripes (0.7 deg2, when combined with archival data). Global structural ...
В результате массового строительства в городе Сочи возникли проблема вымирания и миграции местных животных, а также массовая вырубка редких растений, занесенных в Красную книгу. Тем самым действия человека внесли существенные изменения в местную экосистему. В связи с этим в статье рассмотрены методы сохранения биоразнообразия и поддержания экологич...
