Blackburn, Justin Sharma, Pradeep Liu, Ye Morrisey, Michael A Menachemi, Nir Sen, Bisakha Sanders, Teela Becker, David J
Published in
The Journal of asthma : official journal of the Association for the Care of Asthma
We investigated asthma quality measures to understand patient characteristics associated with non-attainment of quality care and measure the association with asthma-related emergency department (ED) visits or inpatient hospitalizations (IPs). Using administrative data from ALL Kids, Alabama's Children's Health Insurance Program, from 2013 to 2019 w...
Schenz, Judith Rump, Katharina Siegler, Benedikt Hermann Hemmerling, Inga Rahmel, Tim Thon, Jan N. Nowak, Hartmuth Fischer, Dania Hafner, Anna Tichy, Lucas
...
Published in
Frontiers in Immunology
Clonal hematopoiesis of indeterminate potential (CHIP) leads to higher mortality, carries a cardiovascular risk and alters inflammation. All three aspects harbor overlaps with the clinical manifestation of COVID-19. This study aimed to identify the impact of CHIP on COVID-19 pathophysiology. 90 hospitalized patients were analyzed for CHIP. In addit...
Soriano, Francesco Montalto, Claudio Calderone, Dario Nava, Stefano Esposito, Giuseppe Saia, Francesco Oreglia, Jacopo A Søndergaard, Lars
Published in
European heart journal. Case reports
Patients with severe aortic stenosis (AS) and complex coronary artery disease with a clinical indication to both transcatheter aortic valve implantation (TAVI) and percutaneous coronary intervention (PCI) pose a clinical dilemma since it is unclear which lesion should be treated first and careful planning is required. We report two cases of AS with...
Gebregiorgis, Anteneh; Hoang, Anh Du Nguyen; Yu, Jintao; Bishnoi, Rajendra; Taouil, Mottaqiallah; Catthoor, Francky; 14055; Hamdioui, Said;
status: published
Hand, Katherine A Shabek, Nitzan
Chloroplasts are ancient organelles responsible for photosynthesis and various biosynthetic functions essential to most life on Earth. Many of these functions require tightly controlled regulatory processes to maintain homeostasis at the protein level. One such regulatory mechanism is the ubiquitin-proteasome system whose fundamental role is increa...
Wang, Ying Sano, Soichi Ogawa, Hayato Horitani, Keita Evans, Megan A Yura, Yoshimitsu Miura-Yura, Emiri Doviak, Heather Walsh, Kenneth
Published in
Cardiovascular research
Clonal haematopoiesis (CH) is a phenomenon whereby somatic mutations confer a fitness advantage to haematopoietic stem and progenitor cells (HSPCs) and thus facilitate their aberrant clonal expansion. These mutations are carried into progeny leucocytes leading to a situation whereby a substantial fraction of an individual's blood cells originate fr...
f., maria
Circulating tumor DNA (ctDNA) is a component of cell-free DNA (cfDNA) that is shed by malignant tumors into the bloodstream and other bodily fluids. ctDNA can comprise up to 10% of a patient’s cfDNA depending on their tumor type and burden. The short half-life of ctDNA ensures that its detection captures tumor burden in real-time and offers a non-i...
Twersky, Sylvia E.
Published in
International Journal for Equity in Health
Background Restrictive state laws aimed at immigrants can have unintended consequences for health insurance coverage of United States citizens in immigrant families due to both actual barriers created by the laws and perceived barriers among immigrants. Increasing numbers of children in the U.S. are part of immigrant families, and these children ar...
Apriamashvili, Georgi; Vredevoogd, David W; Krijgsman, Oscar; Bleijerveld, Onno B; Ligtenberg, Maarten A; de Bruijn, Beaunelle; 147935; Boshuizen, Julia; Traets, Joleen JH; Altimari, Daniela D'Empaire; van Vliet, Alex;
...
The cytokine IFNγ differentially impacts on tumors upon immune checkpoint blockade (ICB). Despite our understanding of downstream signaling events, less is known about regulation of its receptor (IFNγ-R1). With an unbiased genome-wide CRISPR/Cas9 screen for critical regulators of IFNγ-R1 cell surface abundance, we identify STUB1 as an E3 ubiquitin ...
Achim, Alexandru Marc, Madalin Ruzsa, Zoltan
Published in
Frontiers in Cardiovascular Medicine
Current guidelines, rarely if at all, address decision-making for revascularization when bypass surgery is not a possibility for high-risk cases. Patients who are surgically turned down are routinely excluded from clinical trials, even though they remain symptomatic. Furthermore, the reasons for surgical ineligibility are often times not captured i...
