As human skin comes into contact with the tiny hairs or setae of the oak processionary caterpillar, Thaumetopoea processionea, a silent yet intense chemical confrontation occurs. The result is a mix of issues: skin rashes and an intense itching that typically lasts days and weeks after the contact. This discomfort poses a significant health threat ...
In the current antiretroviral landscape, continuous efforts are still needed to search for novel chemotypes of human immunodeficiency virus type 1 (HIV-1) inhibitors with improved drug resistance profiles and favorable drug-like properties. Herein, we report the design, synthesis, biological characterization, and druggability evaluation of a class ...
status: published
The lithological and stratigraphical heterogeneity of coastal aquifers has a great influence on saltwater intrusion (SI). This makes it difficult to predict SI pathways and their persistence in time. In this context, electrical resistivity tomography (ERT) and induced polarization (IP) methods are receiving increasing attention regarding the discri...
As microbial membranes are naturally impermeable to even the smallest biomolecules, transporter proteins are physiologically essential for normal cell functioning. This makes transporters a key target area for engineering enhanced cell factories. As part of the wider cellular transportome, aquaporins (AQPs) are responsible for transporting small po...
Voltage-gated K+ channels are widely expressed controllers of cellular behavior. Each channel has a gate between the cytosol and its K+ conductive pore to control the flow of potassium. Small molecules that enter through this gate can block the pore. The interface between a channel and its blocker may change during pore closure, producing channel-s...
The objective of the paper is to analyze the stakes associated with the informality in the Tunisian Dates supply chain. We focus on the interdependencies between the formal and informal sectors, interdependencies which have been particularly revealed during the Covid-19 crisis. This crisis has highlighted the fundamental role of the informal sector...
The objective of this research was to assess the effectiveness of the innovation platform (IP) (Terbol Station) on the wheat seed sector in Lebanon. Data were collected from 16 seed producers after identifying and mapping the key stakeholders in the seed sector. Descriptive statistics was used to categorize and evaluate the efficacy of the innovati...
BACKGROUND AND PURPOSE: Antagonists of TRPV1 that inhibit all activation modes cause hyperthermia, hampering their medical use as novel analgesics. TRPV1 antagonists that do not (fully) inhibit responses to low pH do not cause hyperthermia, but it remains incompletely understood how such antagonists affect channel gating. We tested the hypothesis t...
Neuronal swelling is a pathological feature of stroke which contributes to the formation of cytotoxic edema. Under hypoxic condition, aberrant accumulation of sodium and chloride ions inside neurons increases osmotic pressure, leading to cell volume increase. Sodium entry pathway in neurons has been studied extensively. Here, we determine whether S...
