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Morriss, Ginny R. Cooper, Thomas A.
Published in
Human Genetics
An emerging class of long noncoding RNAs (lncRNAs) function as decoy molecules that bind and sequester proteins thereby inhibiting their normal functions. Titration of proteins by lncRNAs has wide-ranging effects affecting nearly all steps in gene expression. While decoy lncRNAs play a role in normal physiology, RNAs expressed from alleles containi...
bai, z. x.-r., chai m.j., yoon h.-j., kim k.a., lo z.-c., zhang d., xu d.t.c., siang a.c.e., walet s.-h., xu
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10.1371/journal.pbio.2002176 / PLoS Biology / 15 / 8 / e2002176
Karch, Celeste M Ezerskiy, Lubov A Bertelsen, Sarah disease, alzheimer’s Goate, Alison M
Late onset Alzheimer's disease (LOAD) is a genetically complex and clinically heterogeneous disease. Recent large-scale genome wide association studies (GWAS) have identified more than twenty loci that modify risk for AD. Despite the identification of these loci, little progress has been made in identifying the functional variants that explain the ...
Suwanwela, Jaijam Farber, Charles R Haung, Bau-Lin Song, Buer Pan, Calvin Lyons, Karen M Lusis, Aldons J
One of the goals of systems genetics is the reconstruction of gene networks that underlie key processes in development and disease. To identify cartilage gene networks that play an important role in bone development, we used a systems genetics approach that integrated microarray gene expression profiles from cartilage and bone phenotypic data from ...
