Wang, Luyao Zhi, Xiaogai Lu, Yingying Cong, Yu Fu, Ziyi Cao, Jian Xu, Sujuan Lv, Juan Ruan, Hongjie
Published in
Archives of gynecology and obstetrics
The aim of our study was to investigate microRNA (miRNA) expression profiles in CD44+ ovarian cancer stem cells (ovarian CSCs). In this study, we enriched CD44+ ovarian CSCs using magnetic activated cell sorting (MACS). A combination of real-time quantitative PCR (qRT-PCR), western blot and sphere formation assays was used to demonstrate stem cell-...
Liao, Chengcheng Wang, Qian An, Jiaxing Chen, Jie Li, Xiaolan Long, Qian Xiao, Linlin Guan, Xiaoyan Liu, Jianguo
Published in
Frontiers in Oncology
The interaction of non-kinase transmembrane glycoprotein CD44 with ligands including hyaluronic acid (HA) is closely related to the occurrence and development of tumors. Changes in CD44 glycosylation can regulate its binding to HA, Siglec-15, fibronectin, TM4SF5, PRG4, FGF2, collagen and podoplanin and activate or inhibit c-Src/STAT3/Twist1/Bmi1, P...
Ying, Weiwei Hu, Yanping Zhu, Haibin
Published in
Frontiers in Surgery
Background Defects in the pelvic floor connective tissue may underlie the etiology of pelvic organ prolapse (POP). We hypothesized that the expression of proteins regulating extracellular matrix turnover is altered in the uterosacral ligament of women with POP. We compared the expression of CD44, transforming growth factor (TGF)-β, and matrix metal...
Choi, Bo-Hyun Ryoo, Ingeun Sim, Kyeong Hwa Ahn, Hyeon-Jin Lee, Youn Ju Kwak, Mi-Kyoung
Published in
Biomolecules & therapeutics
Hyaluronic acid (HA), a ligand of CD44, accumulates in some types of tumors and is responsible for tumor progression. The nuclear factor erythroid 2-like 2 (NRF2) regulates cytoprotective genes and drug transporters, which promotes therapy resistance in tumors. Previously, we showed that high levels of CD44 are associated with NRF2 activation in ca...
Xu, Yingkai Li, Lisong Lou, Suo Tian, Jiashen Sun, Shuhao Li, Xiaodong Li, Yingdong
Published in
Microorganisms
Nanobubble technology has promising development and application prospects in the fields of sewage treatment, soil and groundwater remediation, animal and plant growth, and biomedicine. However, few studies have investigated its effect on shrimp aquaculture. In this study, we investigated the effect of nano-aerators on microbial communities of the w...
Fernández-Tabanera, Enrique Melero-Fernández de Mera, Raquel M. Alonso, Javier
Published in
Frontiers in Oncology
It is widely accepted that the tumor microenvironment, particularly the extracellular matrix, plays an essential role in the development of tumors through the interaction with specific protein-membrane receptors. One of the most relevant proteins in this context is the transmembrane protein CD44. The role of CD44 in tumor progression, invasion, and...
fan;, wu lanyan
In the screening of novel natural products against cancer using an in vitro cancer cell model, we recently found that tanshinones from a traditional Chinese medicine, the rhizome of Salvia miltiorrhiza Bunge (Danshen), had potent effects on cell proliferation and migration. Especially for human osteosarcoma U−2 OS cells, tanshinones significantly e...
Al-Mansoob, Maryam Ahmad, Salma M. S. Ouhtit, Allal
Published in
Frontiers in Oncology
Breast Cancer (BC) is the most common and the major health issue in women worldwide. Metastasis, a multistep process, is the worst aspect of cancer and tumor cell invasion is the defining step. Tumor cell invasion requires cell adhesion molecules (CAMs), and alterations in CAMs is considered as an initiating event in metastasis. Among CAMs, CD44 is...
Soliman, Faris Ye, Lin Jiang, Wenguo Hargest, Rachel
Published in
Clinical colorectal cancer
Peritoneal metastasis (PM) from colorectal cancer (CRC) carries a significant mortality rate for patients and treatment is challenging. The development of PM is a multistep process involving detachment, adhesion, invasion and colonization of the peritoneal cavity. Cytoreductive surgery and HIPEC (hyperthermic intraperitoneal chemotherapy) for PM fr...
Vahedi, Nasrin Tabandeh, Fatemeh Mahmoudifard, Matin
Published in
Biotechnology and applied biochemistry
Nowadays, the use of nanoparticle-based drug delivery systems has received much more attention. In this regard, here, graphene quantum dots (GQD) were used as drug carriers as well as imaging agents for cancer cells. In order to optimize the dose of the drug and reduce its side effects for healthy cells, hyaluronic acid was decorated on the surface...