Li, Jiannan Tan, Yu Sheng, Zhaoxue Zhou, Peng Liu, Chen Zhao, Hanjun Song, Li Zhou, Jinying Chen, Runzhen Chen, Yi
...
Published in
Frontiers in Cardiovascular Medicine
Background: The metabolism of hyaluronan (HA) is widely known to be involved in the process of acute coronary syndrome, but it is unknown how circulating HA levels change in ST-Segment–Elevation Myocardial Infarction (STEMI) patients and whether HA is associated with plaque morphology, including rupture and erosion. Objectives: This study focused o...
Sun, Ying Wang, Yan Li, Zongjin Guo, Zhikun
Published in
Frontiers in Cell and Developmental Biology
Objective The aim of the present study is to isolate and analyze the characterization of pericardial fluid cells (PFCs) from rat and provides a morphological basis for the basic research and clinical application of PFCs. Methods After aseptic thoracotomy was performed, normal saline was injected into the pericardial cavity of 50 adult Sprague–Dawle...
Chen, Qi Gu, Meng Cai, Zhi-Kang Zhao, Hu Sun, Shi-Cheng Liu, Chong Zhan, Ming Chen, Yan-Bo Wang, Zhong
Published in
Cellular and molecular life sciences : CMLS
CD44 is a marker of cancer stem cell (CSC) in many types of tumors. Alternative splicing of its 20 exons generates various CD44 isoforms that have different tissue specific expression and functions, including the CD44 standard isoform (CD44s) encoded by the constant exons and the CD44 variant isoforms (CD44v) with variant exon insertions. Switching...
Moros-Nicolás, Carla Izquierdo-Rico, Mª José Li, Yang González-Brusi, Leopoldo Romar, Raquel Funahashi, Hiroaki
Published in
Reproduction in domestic animals = Zuchthygiene
Crosstalk between the oocyte and surrounding cumulus cells (CCs) is essential for the production of competent oocytes. Previous studies have analysed the relative transcript abundance in oocytes derived from small (SF:
Ishii, Hiroko Mimura, Yuki Zahra, Maram H Katayama, Shota Hassan, Ghmkin Afify, Said M Seno, Masaharu
Published in
American Journal of Cancer Research
Cancer stem cell (CSC) is considered as a cause of cancer recurrence and metastasis. Simultaneously CSCs are responsible for the heterogeneous population in tumor tissues due to their differentiation potential. However, the characterizations of CSCs are still not enough and cancer stem cell lines widely available is desired to be established for th...
Bennett, Marissa Chin, Andrea Lee, Hyung Jin Morales Cestero, Emma Strazielle, Nathalie Ghersi-Egea, Jean-François Threlkeld, Steven W. Schmidt, Tannin A. Richendrfer, Holly A. Szmydynger-Chodobska, Joanna
...
Published in
Journal of Neurotrauma
Neuroinflammation and dysfunction of the blood–brain barrier (BBB) are two prominent mechanisms of secondary injury in neurotrauma. It has been suggested that Toll-like receptors (TLRs) play important roles in initiating and propagating neuroinflammation resulting from traumatic brain injury (TBI), but potential beneficial effects of targeting thes...
Kajiura, Kunihiro Umemura, Naoki Ohkoshi, Emika Ohta, Takahisa Kondoh, Nobuo Kawano, Satoshi
Published in
Connective tissue research
Purpose: In our previous study, we demonstrated that hyaluronan induces odontoblastic differentiation of dental pulp stem cells via interactions with CD44. However, it remains unclear whether CD44 expression by dental pulp stem cells is required for odontoblastic differentiation. Methods: We searched for a compound other than hyaluronan that induce...
Cheng, Yuanyuan Lin, Lishuang Li, Xiaoyan Lu, Aiqi Hou, Chenjian Wu, Qian Hu, Xiaomu Zhou, Zhongwen Chen, Zhongqing Tang, Feng
...
Published in
Cancer Cell International
BackgroundTriple-negative breast cancer (TNBC) is the most challenging breast cancer subtype to treat, because it is so aggressive with shorter survival. Chemotherapy remains the standard treatment due to the lack of specific and effective molecular targets. The aim of the present study is to investigate the potential roles of A Disintegrin and Met...
Li, Mingzhu Jin, Shengbo Cao, Yang Xu, Jian Zhu, Shendong Li, Zheng
Published in
Cancer Cell International
BackgroundNon-small cell lung cancers (NSCLC) account for most cases of lung cancer. More effort is needed to research new drug and combination therapies for this disease. An anthraquinone derivative, emodin shows anticancer potency. We hypothesis that emodin suppresses lung cancer cells through hyaluronan (HA) synthase 2-HA-CD44/receptor for hyalu...
Liao, Chengcheng An, Jiaxing Tan, Zhangxue Xu, Fangping Liu, Jianguo Wang, Qian
Published in
Journal of Cancer
Glycosylation is an important posttranslational modification of proteins, and it has a profound influence on diverse life processes. An abnormal polysaccharide structure and mutation of the glycosylation pathway are closely correlated with human cancer progression. Glycoproteins such as EGFR, E-cadherin, CD44, PD-1/PD-L1, B7-H3 and Muc1 play import...
