Deng, Xiangyang Chen, Kezhu Ren, Junwei Zeng, Jun Zhang, Quan Li, Tianwen Tang, Qisheng Zhu, Jianhong
Published in
Frontiers in Molecular Biosciences
The B7-CD28 gene family plays a crucial role in modulating immune functions and has served as potential targets for immunotherapeutic strategies. Therefore, we systematically analyzed B7-CD28 family gene expression profiles and constructed a B7-CD28 family-based prognostic signature to predict survival and immune host status in diffuse gliomas. The...
Xia, Chang-sheng Long, Yan Liu, Yanying Alifu, Aikede Zeng, Xingyue Liu, Chen
Published in
Frontiers in Immunology
Objectives This study aimed to elucidate the changes and associated mechanisms of circulating CD28- cytotoxic T lymphocytes (CTLs) in patients with IgG4-related disease (IgG4-RD). Methods Fifty IgG4-RD patients and 15 healthy controls (HCs) were recruited. Peripheral blood mononuclear cells (PBMCs) were isolated, the levels of circulating CD28- CTL...
Markousis-Mavrogenis, George Tromp, Jasper Ouwerkerk, Wouter Ferreira, João Pedro Anker, Stefan D Cleland, John G Dickstein, Kenneth Filippatos, Gerasimos Lang, Chim C Metra, Marco
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Published in
Cardiovascular research
The exploration of novel immunomodulatory interventions to improve outcome in heart failure (HF) is hampered by the complexity/redundancies of inflammatory pathways, which remain poorly understood. We thus aimed to investigate the associations between the activation of diverse immune processes and outcomes in patients with HF. We measured 355 bioma...
Lu, Tao-Zhen Liu, Xun Wu, Chang-Song Ma, Zi-You Wang, Yang Zhang, Yong-An Zhang, Xu-Jie
Published in
Frontiers in Immunology
The moderate activation of T cells in mammals requires the costimulatory molecules, CD80 and CD86, on antigen-presenting cells to interact with their respective T cell receptors, CD28 and CD152 (CTLA-4), to promote costimulatory signals. In contrast, teleost fish (except salmonids) only possess CD80/86 as their sole primordial costimulatory molecul...
Chen, Xiong Ji, Shanping Liu, Zheyi Yuan, Xiao Xu, Congsheng Qi, Ruxi He, An Zhao, Heng Song, Haiping Xiao, Chunlei
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Published in
Cell chemical biology
Identification of the tyrosine phosphorylation (pY)-dependent interactome of immune co-receptors is crucial for understanding signal pathways involved in immunotherapy. However, identifying the motif-specific interactome for each pY commonly found on these multi-phosphorylated membrane proteins remains challenging. Here, we describe a photoaffinity...
Chen, Ding-Ping Jaing, Tang-Her Hour, Ai-Ling Lin, Wei-Tzu Hsu, Fang-Ping
Published in
Frontiers in Immunology
Clinically, stem cells with matched human leukocyte antigens (HLAs) must be selected for allogeneic transplantation to avoid graft rejection. However, adverse reactions still occur after cord blood transplantation (CBT). It was inferred that the HLA system is not the only regulatory factor that may influence CBT outcomes. Therefore, we plan to inve...
Rapoport, Bernardo L. Steel, Helen C. Hlatshwayo, Nomsa Theron, Annette J. Meyer, Pieter W. A. Nayler, Simon Benn, Carol-Ann Smit, Teresa Kwofie, Luyanda L. I. Heyman, Liezl
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Published in
Frontiers in Immunology
Breast cancer cells exploit the up-regulation or down-regulation of immune checkpoint proteins to evade anti-tumor immune responses. To explore the possible involvement of this mechanism in promoting systemic immunosuppression, the pre-treatment levels of soluble co-inhibitory and co-stimulatory immune checkpoint molecules, as well as those of cyto...
Pieren, Daan K. J. Smits, Noortje A. M. Postel, Rimke J. Kandiah, Vinitha de Wit, Jelle van Beek, Josine van Baarle, Debbie Guichelaar, Teun
Published in
Frontiers in Immunology
Aging leads to alterations in the immune system that result in ineffective responsiveness against pathogens. Features of this process, collectively known as immunosenescence, accumulate in CD8+ T cells with age and have been ascribed to differentiation of these cells during the course of life. Here we aimed to identify novel markers in CD8+ T cells...
santos, najla
The complete regression of clear cell renal cell carcinoma (ccRCC) obtained pre-clinically with anti-carbonic anhydrase IX (CAIX) G36 chimeric antigen receptor (CAR) T cells in doses equivalent to ≅108 CAR T cells/kg renewed the potential of this target to treat ccRCC and other tumors in hypoxia. The immune checkpoint blockade (ICB) brought durable...
Blaeschke, Franziska Ortner, Eva Stenger, Dana Mahdawi, Jasmin Apfelbeck, Antonia Habjan, Nicola Weißer, Tanja Kaeuferle, Theresa Willier, Semjon Kobold, Sebastian
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Published in
Frontiers in Immunology
Therapeutic targeting of inhibitory checkpoint molecules in combination with chimeric antigen receptor (CAR) T cells is currently investigated in a variety of clinical studies for treatment of hematologic and solid malignancies. However, the impact of co-inhibitory axes and their therapeutic implication remains understudied for the majority of acut...
