Abdel-Rahman, Lama Izzat Hasan Morgan, Xochitl C
Inflammatory bowel diseases
To assess reproducibility in inflammatory bowel disease microbiome research, we performed a meta-analysis of 13 inflammatory bowel disease studies, measuring effects of disease and sample type. Crohn’s disease studies were more heterogeneous than ulcerative colitis studies, and sample type variation was a major contributor to inconsistency.
bao, zhongli cheng, ya-chi wei, justin jun luo, mary ziping zhang, jack yongfeng
Glucagon, a 29-amino acid polypeptide hormone, is an essential therapeutic agent used in the emergency treatment of hypoglycemia. However, glucagon is inherently unstable in aqueous solution. While glucagon equilibrates between unordered and the secondary α-helix state in solution, it can quickly transform into a different secondary β-sheet-rich am...
Buonocore, Michela Santoro, Angelo Grimaldi, Manuela Covelli, Verdiana Firoznezhad, Mohammad Rodriquez, Manuela Santin, Matteo D'Ursi, Anna Maria
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an RNA virus identified as the cause of the coronavirus outbreak in December 2019 (COVID-19). Like all the RNA viruses, SARS-CoV-2 constantly evolves through mutations in its genome, accumulating 1-2 nucleotide changes every month, giving the virus a selective advantage through enhance...
Chen, Jie Dan, Lintao Tu, Xinru Sun, Yuhao Deng, Minzi Chen, Xuejie Hesketh, Therese Li, Ran Wang, Xiaoyan Li, Xue
Metabolic dysfunction-associated fatty liver disease (MAFLD) is recently recognized as a condition featured with metabolic dysfunctions in liver. It has been supposed that MAFLD might contribute to the development of IBD, but evidence from prospective cohort studies is lacking and inconclusive. A total of 221,546 females and 183,867 males from the ...
Chegini, Azita Fani, Parvaneh Samiee, Shahram Shaiegan, Mojgan Hajati, Esmerdis Maghari, Amirhossein
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
The aim of this study was to evaluate and compare two different apheresis and changes in some immunological factors in donors. The cross-sectional study was performed from January 2017 to September 2018. Fifty six male blood donors were randomly divided into two groups. CD4, CD8, and CD25 markers by flow cytometry, and TGFBeta by real-time polymera...
Tripathi, Kartikeya Godoy Brewer, Gala Thu Nguyen, Minh Singh, Yuvaraj Saleh Ismail, Mohamed Sauk, Jenny S Parian, Alyssa M Limketkai, Berkeley N
Inflammatory bowel diseases
Our understanding of coronavirus disease 2019 (COVID-19) and its implications for patients with inflammatory bowel diseases (IBD) is rapidly evolving. We performed a systematic review and meta-analysis to investigate the epidemiology, clinical characteristics, and outcomes in IBD patients with COVID-19. We searched PubMed, EMBASE, Cochrane Central,...
Beltman, Lieke Roorda, Daniëlle Backes, Manouk Oosterlaan, Jaap van Heurn, L W Ernest Derikx, Joep P M
Journal of pediatric surgery
Transanal endorectal pull-through (TERPT) is a common surgical procedure in Hirschsprung disease (HD). Aim of this study was to gain insight in the prevalence and severity of postoperative complications within 30-days after TERPT and to identify patient and perioperative characteristics, associated with the development of short-term postoperative c...
Wanner, Christoph Kimonis, Virginia Politei, Juan Warnock, David G Üçeyler, Nurcan Frey, Aline Cornelisse, Peter Hughes, Derralyn
The use of available treatments for Fabry disease (FD) (including enzyme replacement therapy [ERT]) may be restricted by their limited symptom improvement and mode of administration. Lucerastat is currently being investigated in the MODIFY study as oral substrate reduction therapy for the treatment of FD. By reducing the net globotriaosylceramide (...
Passias, Peter G Pierce, Katherine E Horn, Samantha R Segar, Anand Passfall, Lara Kummer, Nicholas Krol, Oscar Bortz, Cole Brown, Avery E Alas, Haddy
International journal of spine surgery
To assess whether surgical cervical deformity (CD) patients meet spinopelvic age-adjusted alignment targets, reciprocal, and lower limb compensation changes. Retrospective review. CD was defined as C2-C7 lordosis >10°, cervical sagittal vertical angle (cSVA) >4 cm, or T1 slope minus cervical lordosis (TS-CL) >20°. Inclusion criteria were age >18 ye...
Kwan, Tristan O. C. Kolek, Stefan A. Danson, Amy E. Reis, Rosana I. Camacho, Ines S. Shaw Stewart, Patrick D. Moraes, Isabel
Frontiers in Molecular Biosciences
Structure-function relationships of biological macromolecules, in particular proteins, provide crucial insights for fundamental biochemistry, medical research and early drug discovery. However, production of recombinant proteins, either for structure determination, functional studies, or to be used as biopharmaceutical products, is often hampered b...