Zhou, Kai Zisiadis, Georgios Alkis Havermans, Monique Fragkopoulou, Adamantia Dominguez, Cecilia Ohshima, Makiko Osman, Ahmed M Rodrigues, Carlos F D Blomgren, Klas
Published in
Brain, behavior, and immunity
Cranial radiotherapy can cause lifelong cognitive complications in childhood brain tumor survivors, and reduced hippocampal neurogenesis is hypothesized to contribute to this. Following irradiation (IR), microglia clear dead neural progenitors and give rise to a neuroinflammatory microenvironment, which promotes a switch in surviving progenitors fr...
Zhao, Duanchong Yu, Xingxing Huang, Hongli Zou, Shuqing Zhu, Pingxiu Lin, Yuxiang Song, Mengjie Fu, Fangmeng Yang, Haomin
Published in
Frontiers in Oncology
Background Chemokines are well-known for playing an essential role in the development of cancer. However, the association between SNPs in the CCL2 and CXCL12 genes and the susceptibility to breast cancer remains unclear. Methods A case-control study was conducted in southeast China, including 1855 breast cancer patients and 1838 cancer-free control...
mofed, dina mandarino, angelo xuhong, wu lang, yuekun gowripalan, anjali kalpana, ganjam v. prasad, vinayaka r.
HIV-1 subtype C viruses are responsible for 50% of global HIV burden. However, nearly all currently available reporter viruses widely used in HIV research are based on subtype B. We constructed and characterized a replication-competent HIV-1 subtype C reporter virus expressing mGreenLantern. mGreenLantern sequences were inserted in-frame with Nef A...
Kim, William S. Prasongyuenyong, Kawintip Ko, Annette Debnath, Rahul Chen, Zhaoxu Zhou, Jonathan X. Shaaf, Emon Ko, Kang I.
Published in
Frontiers in Immunology
Tissue-resident fibroblasts are heterogeneous and provide an endogenous source of cytokines that regulate immunologic events in many osteolytic diseases. Identifying distinct inflammatory fibroblast subsets and conducting mechanistic in vivo studies are critical for understanding disease pathogenesis and precision therapeutics, which is poorly expl...
Ji, En Zhang, Yuanyuan Li, Zhiqiang Wei, Lai Wu, Zhaofa Li, Yulong Yu, Xiang Song, Tian-Jia
Published in
Neuroscience bulletin
The CC chemokine ligand 2 (CCL2, also known as MCP-1) and its cognate receptor CCR2 have well-characterized roles in chemotaxis. CCL2 has been previously shown to promote excitatory synaptic transmission and neuronal excitability. However, the detailed molecular mechanism underlying this process remains largely unclear. In cultured hippocampal neur...
Wang, Lei Zheng, Guimin Wang, Peiwen Jia, Xiuchuan
Published in
Frontiers in Immunology
Background This study employed RNA-seq technology and meta-analysis to unveil the molecular mechanisms of neuropsychiatric systemic lupus erythematosus (NPSLE) within the central nervous system. Methods Downloaded transcriptomic data on systemic lupus erythematosus (SLE) from the Gene Expression Omnibus (GEO) and analyzed differential genes in peri...
Panek, WK Toedebusch, RG Mclaughlin, BE Dickinson, PJ Van Dyke, JE Woolard, KD Berens, ME Lesniak, MS Sturges, BK Vernau, KM
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PurposeSpontaneously occurring glioma in pet dogs is increasingly recognized as a valuable translational model for human glioblastoma. Canine high-grade glioma and human glioblastomas share many molecular similarities, including the accumulation of immunosuppressive regulatory T cells (Tregs) that inhibit anti-tumor immune responses. Identifying in...
höfling, corinna ulrich, luise burghardt, sina donkersloot, philippa opitz, michael geissler, stefanie schilling, stephan cynis, holger michalski, dominik roßner, steffen
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Glutaminyl cyclase (QC) and its isoenzyme (isoQC) catalyze the formation of N-terminal pyroglutamate (pGlu) from glutamine on a number of neuropeptides, peptide hormones and chemokines. Chemokines of the C-C ligand (CCL) motif family are known to contribute to inflammation in neurodegenerative conditions. Here, we used a model of transient focal ce...
Jing-Lun, Zhan Shuang, Chai Li-Mei, Zhao Xiao-Dong, Liu
Published in
Frontiers in Pharmacology
marsland, mark jiang, chen chen faulkner, sam steigler, allison mcewan, kristen jobling, phillip oldmeadow, christopher delahunt, brett denham, james w. hondermarck, hubert
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This study investigated the prognostic value of the chemokine C-C motif ligand 2 (CCL2) and its receptor C-C motif chemokine receptor 2 (CCR2) expression in locally advanced prostate cancer treated with radiotherapy and androgen deprivation using the 10-year outcome data from the TROG 03.04 RADAR clinical trial. CCL2 and CCR2 protein expression in ...
