Han, Yingying Dong, Qianyu Peng, Jiyun Li, Baoming Sun, Chong Ma, Chaolin
Published in
Molecular neurobiology
Cannabis is an annual herb of the genus Cannabis, with a history of medical use going back thousands of years. However, its abuse causes many side-effects, including confusion of consciousness, alienation, and mental disorders such as schizophrenia and depression. Research conducted on rodents suggests that there are two types of cannabinoid recept...
Osiak-Wicha, Cezary Muszyński, Siemowit Tomaszewska, Ewa Kras, Katarzyna Ropka-Molik, Katarzyna Zhyla, Mykola Arciszewski, Marcin Bartłomiej
Published in
Annals of Animal Science
The gastrointestinal tract plays a crucial role in nutrient absorption, secretion, and motility, ensuring proper digestion and overall homeostasis. Regulation of this complex system involves the coordination of various communication pathways, including neural and humoral mechanisms. One such mechanism is the endocannabinoid system (ECS), a signalin...
socha, justyna grochecki, pawel marszalek-grabska, marta skrok, aleksandra smaga, irena slowik, tymoteusz prazmo, wojciech kotlinski, robert filip, malgorzata kotlinska, jolanta h.
...
Cannabidiol (CBD), a phytocannabinoid, appeared to satisfy several criteria for a safe approach to preventing drug-taking behavior, including opioids. However, most successful preclinical and clinical results come from studies in adult males. We examined whether systemic injections of CBD (10 mg/kg, i.p.) during extinction of oxycodone (OXY, 3 mg/k...
Wreven, Elise Ruiz de Adana, María Soledad Hardivillé, Stéphan Gmyr, Valery Pattou Kerr-Conte, Julie Chetboun, Mikael Pasquetti, Gianni Delalleau, Nathalie Thevenet, Julien Coddeville, Anaïs
...
Aims/hypothesisInsulitis, a hallmark of inflammation preceding autoimmune type 1 diabetes, leads to the eventual loss of functional beta cells. However, functional beta cells can persist even in the face of continuous insulitis. Despite advances in immunosuppressive treatments, maintaining functional beta cells to prevent insulitis progression and ...
Cinar, Resat Basu, Abhishek Arif, Muhammad Park, Joshua K Zawatsky, Charles N Zuo, Ben Long G Zuo, Mei Xing G O'Brien, Kevin J Behan, Molly Introne, Wendy
...
Published in
medRxiv : the preprint server for health sciences
Hermansky-Pudlak syndrome (HPS) is a group of rare genetic disorders, with several subtypes leading to fatal adult-onset pulmonary fibrosis (PF) and no effective treatment. Circulating biomarkers detecting early PF have not been identified. We investigated whether endocannabinoids could serve as blood biomarkers of PF in HPS. We measured endocannab...
shivshankar, samay nimely, josephine puhl, henry iyer, malliga r.
Cannabinoid receptors CB1R and CB2R are G-protein coupled receptors acted upon by endocannabinoids (eCBs), namely 2-arachidonoylglycerol (2-AG) and N-arachidonoyl ethanolamine (AEA), with unique pharmacology and modulate disparate physiological processes. A genetically encoded GPCR activation-based sensor that was developed recently—GRABeCB2.0—has ...
Tang, Yi Wang, Maoru Yu, Jiangping Lv, Guangyao Wang, Yu Yu, Bin
Published in
Frontiers in Pharmacology
Approximately 80% of all malignant brain tumors are gliomas, which are primary brain tumors. The most prevalent subtype of glioma, glioblastoma multiforme (GBM), is also the most deadly. Chemotherapy, immunotherapy, surgery, and conventional pharmacotherapy are currently available therapeutic options for GBM; unfortunately, these approaches only pr...
Guo, Baolin Xi, Kaiwen Mao, Honghui Ren, Keke Xiao, Haoxiang Hartley, Nolan D Zhang, Yangming Kang, Junjun Liu, Yingying Xie, Yuqiao
...
Published in
Neuron
Social isolation is a risk factor for multiple mood disorders. Specifically, social isolation can remodel the brain, causing behavioral abnormalities, including sociability impairments. Here, we investigated social behavior impairment in mice following chronic social isolation stress (CSIS) and conducted a screening of susceptible brain regions usi...
Cherry, Amy L. Wheeler, Michael J. Mathisova, Karolina Di Miceli, Mathieu
Published in
Frontiers in Neuroinformatics
Introduction The endocannabinoid (eCB) system is named after the discovery that endogenous cannabinoids bind to the same receptors as the phytochemical compounds found in Cannabis. While endogenous cannabinoids include anandamide (AEA) and 2-arachidonoylglycerol (2-AG), exogenous phytocannabinoids include Δ-9 tetrahydrocannabinol (THC) and cannabid...
Nasretdinov, Azat Jappy, David Vazetdinova, Alina Valiullina-Rakhmatullina, Fliza Rozov, Andrei
Published in
Frontiers in Cellular Neuroscience
Feed-forward inhibition is vital in the transfer and processing of synaptic information within the hippocampal–entorhinal loop by controlling the strength and direction of excitation flow between different neuronal populations and individual neurons. While the cellular targets in the hippocampus that receive excitatory inputs from the entorhinal co...