Intervertebral disc degeneration is a ubiquitous condition closely linked to chronic low-back pain. The health of the avascular nucleus pulposus (NP) plays a crucial role in the development of this pathology. We tested the hypothesis that a network comprising HIF-1α, carbonic anhydrase (CA) 9 and 12 isoforms, and sodium-coupled bicarbonate cotransp...
Ulcerative colitis (UC) is associated with lowintracolonic pH and unbalanced transmucosal ionicexchanges. Along the gastrointestinal tract carbonicanhydrase isoenzyme I (CA-I) is specifically expressed in colon epithelium and is involved in mucosalcontrol of ion, fluid, and acid- base balance. Sincealtered CA-I expression may play some role in UC, ...
