Azimi, Parham Keshavarz, Zahra Lahaie Luna, Marianne Cedeno Laurent, Jose Guillermo Vallarino, Jose Christiani, David C Allen, Joseph G
Published in
International journal of environmental research and public health
Up to 95% of the liquid volume in an e-cigarette consists of propylene glycol. Previous research has shown that propylene glycol can generate diacetyl and formaldehyde when heated. New research shows that propylene glycol can also generate methylglyoxal, an alpha di-carbonyl compound recently shown to cause epithelial necrosis at even lower concent...
Tan, Ya Gan, Mailin Shen, Linyuan Li, Liang Fan, Yuan Chen, Ying Chen, Lei Niu, Lili Zhao, Ye Jiang, Anan
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Published in
International journal of molecular sciences
Gene transcripts or mRNAs and long noncoding RNAs (lncRNAs) are differentially expressed during porcine skeletal muscle development. However, only a few studies have been conducted on skeletal muscle transcriptome in pigs based on timepoints according to the growth curve for porcine. Here, we investigated gene expression in Qingyu pigs at three dif...
Scragg, Robert Sluyter, John D
Published in
JBMR Plus
Scientific interest in possible extraskeletal effects of vitamin D first appeared in the 1930s soon after the structure of vitamin D was characterized, and increased in the 1980s with the development of assays of 25‐hydroxyvitamin D status as a marker of vitamin D status, which in observational epidemiological studies was shown to be inversely asso...
Backers, Lynn Parton, Bram De Bruyne, Marieke Tavernier, Simon Van Den Bogaert, Kris Lambrecht, Bart Haerynck, Filomeen Claes, Kathleen
Pathogenic biallelic variants in theBLM/RECQL3gene cause a rare autosomal recessive disorder called Bloom syndrome (BS). This syndrome is characterized by severe growth delay, immunodeficiency, dermatological manifestations and a predisposition to a wide variety of cancers, often multiple and very early in life. Literature shows that the main mode ...
Buratin, Alessia Paganin, Maddalena Gaffo, Enrico Dal Molin, Anna Roels, Juliette Germano, Giuseppe Siddi, Maria Teresa Serafin, Valentina De Decker, Matthias Gachet, Stéphanie
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Published in
Blood advances
Circular RNAs (circRNAs) are stable RNA molecules that can drive cancer through interactions with microRNAs and proteins and by the expression of circRNA encoded peptides. The aim of the study was to define the circRNA landscape and potential impact in T-cell acute lymphoblastic leukemia (T-ALL). Analysis by CirComPara of RNA-sequencing data from 2...
Jennings, Nicholas Chambaere, Kenneth Chamely, Stacey Macpherson, Cheryl C Deliens, Luc Cohen, Joachim
Published in
Journal of pain and symptom management
Empirical information on circumstances of dying from advanced illness in developing countries remains sparse. Evidence indicates that out-of-hospital end-of-life care can have significant benefits such as increased satisfaction for the patient and caregivers and cost-effective for a health-care system. Services that are aimed to deliver care at pri...
van Bussel, Mark TJ; Awada, Ahmad; de Jonge, Maja JA; Mau-Sorensen, Morten; Nielsen, Dorte; Schoffski, Patrick; 46480; Verheul, Henk MW; Sarholz, Barbara; Berghoff, Karin; El Bawab, Samer;
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BACKGROUND: This open-label, phase 1 trial (NCT02316197) aimed to determine the maximum-tolerated dose (MTD) and/or recommended phase 2 dose (RP2D) of peposertib (formerly M3814), a DNA-dependent protein kinase (DNA-PK) inhibitor in patients with advanced solid tumours. Secondary/exploratory objectives included safety/tolerability, pharmacokinetic/...
Zhang, Dongjian; Jin, Qiaomei; Gao, Meng; Jiang, Cuihua; Ni, Yicheng; 14498; Zhang, Jian;
Glucarate, a physiologic end-product of the D-glucuronic acid pathway in mammals, is a six-carbon dicarboxylic acid with a wide range of uses. Glucarate-based molecular imaging probes including [99mTc]glucarate and [18F]glucarate have been developed and demonstrated to have infarct/necrosis-avid and/or tumor-seeking properties, showing potential ap...
Orlovic, M Callender, T Riley, J Darzi, A Droney, J
Place of death is an important outcome of end-of-life care. Many people do not have the opportunity to express their wishes and die in their preferred place of death. Advance care planning (ACP) involves discussion, decisions and documentation about how an individual contemplates their future death. Recording end-of-life preferences gives patients ...
Rao, A Dhahri, AA Razzaq, H Mokhtari, E Majeed, A Patel, A
Introduction The study aimed to assess the accuracy of online software in the use of self-referral to breast surgery clinics for patients with new signs and symptoms. The study also evaluated the appropriateness of GP referrals to breast clinics and evaluated patients' perceptions of an online self-referral portal to the breast clinic for the asses...
