Brekke, Lene Kristin Fevang, Bjørg-Tilde Svanes Diamantopoulos, Andreas P Assmus, Jörg Esperø, Elisabet Gjesdal, Clara Gram
Published in
The Journal of rheumatology
To determine the risk of cancer in a large Norwegian cohort of patients with giant cell arteritis (GCA). This is a hospital-based, retrospective, observational cohort study including patients diagnosed with GCA in the Bergen Health Area during 1972-2012. Patients were identified through computerized hospital records using the International Classifi...
Bandini, Marco; Albersen, Maarten; 64231; Chipollini, Juan; Pederzoli, Filippo; Zhu, Yao; Ye, Ding-Wei; Ornellas, Antonio A; Watkin, Nick; Ager, Michael; Hakenberg, Oliver W;
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OBJECTIVES: To identify predictors of poor overall survival (OS) amongst patients with penile squamous cell carcinoma (pSCC) with clinical inguinal lymphadenopathy (cN+), in order to define the best candidates for neoadjuvant chemotherapy (NAC). PATIENTS AND METHODS: Using an international, multicentre database of 924 patients with pSCC, we identif...
Rao, Srinivasa R Edwards, Claire M Edwards, James R
Published in
JBMR Plus
Bone is the most common site for cancer metastasis. Understanding the interactions within the complex, heterogeneous bone–tumor microenvironment is essential for the development of new therapeutics. Various animal models of tumor‐induced bone disease are routinely used to provide valuable information on the relationship between cancer cells and the...
Perry, H Botnar, R Wilton-Ely, J
Over the last decade, much work has been dedicated to improving the performance of gadolinium-based magnetic resonance imaging (MRI) contrast agents by tethering them to biocompatible gold nanoparticles. The enhancement in performance (measured in terms of ‘relaxivity’) stems from the restriction in motion experienced by the gadolinium chelates on ...
Hernandez-Sanabria, Emma Heiremans, Evelien Calatayud Arroyo, Marta Props, Ruben Leclercq, Laurent Snoeys, Jan Van de Wiele, Tom
Published in
npj Biofilms and Microbiomes
Celecoxib has been effective in the prevention and treatment of chronic inflammatory disorders through inhibition of altered cyclooxygenase-2 (COX-2) pathways. Despite the benefits, continuous administration may increase risk of cardiovascular events. Understanding microbiome-drug-host interactions is fundamental for improving drug disposition and ...
Bellido, Teresita Delgado‐Calle, Jesus
Published in
JBMR Plus
The integrity of the skeleton is maintained by the coordinated and balanced activities of the bone cells. Osteoclasts resorb bone, osteoblasts form bone, and osteocytes orchestrate the activities of osteoclasts and osteoblasts. A variety of in vitro approaches has been used in an attempt to reproduce the complex in vivo interactions among bone cell...
Helsen, Nils; Van den Wyngaert, Tim; Carp, Laurens; De Bree, Remco; VanderVeken, Olivier M; De Geeter, Frank; Maes, Alex; Cambier, Jean-Philippe; Spaepen, Karoline; Martens, Michel;
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BACKGROUND: The Hopkins criteria were introduced for nodal response evaluation after therapy in head and neck cancer, but its superiority over quantification is not yet confirmed. METHODS: SUVbody weight thresholds and lesion-to-background ratios were explored in a prospective multicenter study of standardized FDG-PET/CT 12 weeks after CRT in newly...
Tzafetas, M Mitra, A Paraskevaidi, M Bodai, Z Kalliala, I Bowden, S Lathouras, K Rosini, F Szasz, M Savage, A
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Clearance of surgical margins in cervical cancer prevents the need for adjuvant chemoradiation and allows fertility preservation. In this study, we determined the capacity of the rapid evaporative ionization mass spectrometry (REIMS), also known as intelligent knife (iKnife), to discriminate between healthy, preinvasive, and invasive cervical tissu...
Paczkowska, Marta Barenboim, Jonathan Sintupisut, Nardnisa Fox, Natalie S. Zhu, Helen Abd-Rabbo, Diala Mee, Miles W. Boutros, Paul C. Abascal, Federico Amin, Samirkumar B.
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Published in
Nature Communications
Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.
Gou, Yixing Zhang, Shuai Sun, Changku Wang, Peng You, Zheng Yalikun, Yaxiaer Tanaka, Yo Ren, Dahai
Efficient and reliable manipulation of biological particles is crucial in medical diagnosis and chemical synthesis. Inertial microfluidic devices utilizing passive hydrodynamic forces in the secondary flow have drawn considerable attention for their high throughputs, low costs, and harmless particle manipulation. However, as the dominant mechanism,...
