Pulmonary airway epithelial cells (AECs) form a critical interface between host and environment. We investigated the role of the circadian clock using mice bearing targeted deletion of the circadian gene brain and muscle ARNT-like 1 (Bmal1) in AECs. Pulmonary neutrophil infiltration, biomechanical function, and responses to influenza infection were...
Regulatory T (Treg) cells, which are broadly classified as thymically derived (tTreg) or extrathymically induced (iTreg), suppress immune responses and display stringent dependence to the transcription factor Foxp3. However precise understanding of molecular events that promote and preserve Foxp3 expression in Treg cells is still evolving. Here we ...
10.1371/journal.pbio.2004874 / PLoS Biology / 16 / 9 / e2004874
10.1371/journal.pone.0190063 / PLoS ONE / 13 / 1 / e0190063
10.1371/journal.pone.0205583 / PLoS ONE / 13 / 10 / e0205583
10.1371/journal.pone.0192531 / PLoS ONE / 13 / 2 / e0192531
10.1371/journal.pone.0192717 / PLoS ONE / 13 / 2 / e0192717
Colon cancer is one of the most common death-related cancers in the world. For treating colon cancer, it is crucial to detect and remove malignant lesions early. Here, we developed hyaluronate (HA)-peanut agglutinin (PNA) conjugates for the bioimaging of colon cancer. The HA-PNA conjugates were successfully synthesized by the coupling reaction betw...
10.1371/journal.pbio.2002176 / PLoS Biology / 15 / 8 / e2002176
10.1371/journal.pone.0176345 / PLoS ONE / 12 / 4 / e0176345
