Published in Frontiers in Aging
In multicellular organisms such as Caenorhabditis elegans, cellular stress stimuli and responses are communicated between tissues to promote organismal health- and lifespan. The nervous system is the predominant regulator of cell nonautonomous proteostasis that orchestrates systemic stress responses to integrate both internal and external stimuli. ...
Published in Nutritional neuroscience
Fructose-common sweetener, consumed in large quantities, is now known to be associated with various metabolic diseases. Recent reports suggest fructose's involvement in neurodegeneration, neurotoxicity, and neuroinflammation. But, its impact at cellular and subcellular level and on energy metabolism, especially, mitochondrial bioenergetics, in neur...
Published in Current Research in Toxicology
Exposure to particulate matter (PM) air pollution increases risk of adverse human health effects. As more attention is brought to bear on the problem of PM, traditional mammalian in vivo models struggle to keep up with the risk assessment challenges posed by the countless number of unique PM samples across air sheds with limited or no toxicity info...
Particulate matter (PM) is air pollution comprised of tiny particles suspended in the air. Exposure to PM is a major global health concern, contributing to 9 million deaths annually. Fine PM can break down protective cellular barriers and cause systemic inflammation, leading to damage of the central nervous and respiratory systems. Children are esp...
Published in Frontiers in Behavioral Neuroscience
Exposure to alcohol causes deficits in long-term memory formation across species. Using a long-term habituation memory assay in Caenorhabditis elegans, the effects of ethanol on long-term memory (> 24 h) for habituation were investigated. An impairment in long-term memory was observed when animals were trained in the presence of ethanol. Cues of in...
Published in Proceedings of the National Academy of Sciences of the United States of America
SignificanceAging animals, particularly females, suffer from diminished reproductive ability, likely due to high costs of germline maintenance. Potential remedies may be found in signals exchanged by members of opposite sexes to promote reproductive success. We show that in the nematode Caenorhabditis elegans, male pheromone facilitates healthy ooc...
Food-grade titanium dioxide (E171) contains variable percentages of titanium dioxide (TiO2) nanoparticles (NPs), posing concerns for its potential effects on human and animal health. Despite many studies, the actual relationship between the physicochemical properties of E171 NPs and their interaction with biological targets is still far from clear....
Published in Redox Biology
• Mitochondrial thioredoxin system genes are specifically upregulated in long-lived mitochondrial mutants. • Upregulation of mitochondrial thioredoxin genes is mediated by mitochondrial unfolded protein response. • Mitochondria thioredoxin genes contribute to lifespan extension in long-lived mitochondrial mutants. • Mitochondrial thioredoxin genes ...
Published in Frontiers in Microbiology
Graphical abstract of the approach employed in this study. Combined analyses of C. elegans-microbe transcriptomics (1) and gene tissue expression maps (2), with high-throughput stress and infection assays following host-gene inactivation (3), can guide predictions and accelerate identification of genetic interactions involved in nematode-microbe in...
Published in Frontiers in Neuroanatomy
Studies on sexual dimorphism in the structure and function of the nervous system have been pivotal to understanding sex differences in behavior. Such studies, especially on invertebrates, have shown the importance of neurons specific to one sex (sex-specific neurons) in shaping sexually dimorphic neural circuits. Nevertheless, recent studies using ...
