Fang, Minglv Liu, Ying Gao, Xiaoyan Yu, Jing Tu, Xiaohui Mo, Xueying Zhu, Huanhu Zou, Yan Huang, Cheng Fan, Shengjie
...
Published in
BioFactors (Oxford, England)
Huntington's disease (HD) is a fatal neurodegenerative disease associated with autophagy disorder and mitochondrial dysfunction. Here, we identified therapeutic potential of perillaldehyde (PAE), a monoterpene compound obtained from Perilla frutescens (L.) Britt., in the Caenorhabditis elegans (C. elegans) model of HD, which included lifespan exten...
Kimura, Kenji Motegi, Fumio
Published in
Methods in molecular biology (Clifton, N.J.)
Cytoplasmic streaming is the bulk flow of cytoplasm observed, not only in plants but also in animal oocytes and embryos. The flow of viscous fluid within the cytoplasm generates forces that re-arrange intracellular organelles, such as mitotic spindles and nuclei, to regulate cell growth, migration, and polarity. Cytoplasmic streaming is established...
Dumont, Julien Maton, Gilliane
Published in
Methods in molecular biology (Clifton, N.J.)
Maintaining genomic integrity throughout successive cell divisions is essential for the proper development and functioning of organisms. Chromosome alignment and segregation occur on a microtubule-based spindle originating from centrosomes. The molecular and cellular mechanisms involved in accurate chromosome segregation during early embryonic divi...
Suraci, Cameron M. Morrison, Michael L. Roth, Mark B.
Published in
Frontiers in Physiology
Introduction Temperature and oxygen are two factors that profoundly affect survival limits of animals; too much or too little of either is lethal. However, humans and other animals can exhibit exceptional survival when oxygen and temperature are simultaneously low. This research investigates the role of oxygen in the cold shock death of Caenorhabdi...
Caron, Laury Alonzo De la Rosa, Claudia Miriam Diop, Khoudia Miard, Stéphanie Taubert, Stefan Marette, André Picard, Frédéric
Published in
Frontiers in Microbiomes
Background and aims Current research on host-gut microbiota interactions is hindered by almost infinite bacterial combinations depending on intrinsic characteristics, environment, and health status, which prevents large-scale screenings in mammals. For these reasons, the bacterivore model organism C. elegans has been developed to test the effects o...
Xue, Feng Ragno, Martina Blackburn, Sarah A. Fasseas, Michael Maitra, Sushmita Liang, Mingzhi Rai, Subash Mastroianni, Giulia Tholozan, Frederique Thompson, Rachel
...
Published in
Frontiers in Cellular and Infection Microbiology
Introduction Antimicrobial resistance is a growing health problem. Pseudomonas aeruginosa is a pathogen of major concern because of its multidrug resistance and global threat, especially in health-care settings. The pathogenesis and drug resistance of P. aeruginosa depends on its ability to form biofilms, making infections chronic and untreatable a...
Mattout, Anna Gaidatzis, Dimos Padeken, Jan Schmid, Christoph Aeschlimann, Florian Kalck, Véronique
In fission yeast and plants, RNA-processing pathways contribute to constitutive and facultative heterochromatin silencing, complementing well-characterized pathways of transcriptional repression. However, it was unclear whether this additional level of regulation occurs in metazoans. Here we describe a pathway of silencing in C. elegans somatic cel...
Dutta, Naibedya Gerke, Joe A Odron, Sofia F Morris, Joseph D Hruby, Adam Kim, Juri Torres, Toni Castro Shemtov, Sarah J Clarke, Jacqueline G Chang, Michelle C
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Published in
GeroScience
Small molecule inhibitors of the mitochondrial electron transport chain (ETC) hold significant promise to provide valuable insights to the field of mitochondrial research and aging biology. In this study, we investigated two molecules: mycothiazole (MTZ) - from the marine sponge C. mycofijiensis and its more stable semisynthetic analog 8-O-acetylmy...
Kolodziejska, Klaudia Szczepanska, Agata Pujol, Nathalie Pokrzywa, Wojciech Turek, Michal
Extracellular vesicles (EVs) play a crucial role in immune responses, yet it remains unclear whether pathogen metabolites alone can stimulate EV production prior to infection. Using Caenorhabditis elegans, we investigate this question through the lens of exophers: large, evolutionarily conserved EVs known to enhance proteostasis, extend lifespan, a...
Hajji, Ismail Siggia, Eric Corson, Francis Keil, Wolfgang
During development, cells gradually assume specialized fates via changes of transcriptional dynamics in thousands of genes. Terminal cell identities are then stabilized through the convergence of gene regulatory network dynamics and the accumulation of epigenetic DNA modifications. "Gene-free" (or geometric) modeling approaches for cell fate acquis...
