Pooranachithra, Murugesan Bhaskar, James Prabhanand Murali, Deepa Das, Shibendu Sekhar JebaMercy, Gnanasekaran Krishnan, Venkateswaran Balamurugan, Krishnaswamy
Published in
Life sciences
In the current scenario of ethical issues related to animal usage in research, the present study was intended to explore the proficient utility of nematode, Caenorhabditis elegans as wound model in preliminary screening of wound healing therapeutics. In this study, a new wounding protocol and quantitative assessment strategies for various healing p...
Zhou, Jie-jun Chun, Lei Liu, Jian-feng
Published in
Current Medical Science
Diet has been shown to play an important role in human physiology. It is a predominant exogenous factor regulating the composition of gut microbiota, and dietary intervention holds promise for treatment of diseases such as obesity, type 2 diabetes, and malnutrition. Furthermore, it was reported that diet has significant effects on physiological pro...
Dahiya, Yogesh Rose, Saloni Thapliyal, Shruti Bhardwaj, Shivam Prasad, Maruthi Babu, Kavita
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Memory formation is crucial for the survival of animals. Here, we study the effect of different crh-1 [Caenorhabditis elegans homolog of mammalian cAMP response element binding protein 1 (CREB1)] isoforms on the ability of C. elegans to form long-term memory (LTM). Null mutants in creb1/crh-1 are defective in LTM formation across phyla. We show tha...
Touati, Rabeb Oueslati, Afef Elloumi Messaoudi, Imen Lachiri, Zied
Published in
Medical & biological engineering & computing
Helitrons are mobile sequences which belong to the class 2 of eukaryotic transposons. Their specificity resides in their mechanism of transposition: the rolling circle mechanism. They play an important role in remodeling proteomes due to their ability to modify existing genes and introducing new ones. A major difficulty in identifying and classifyi...
Cahoon, Cori K Helm, Jacquellyn M Libuda, Diana E
Published in
Genetics
Crossovers (COs) between homologous chromosomes are critical for meiotic chromosome segregation and form in the context of the synaptonemal complex (SC), a meiosis-specific structure that assembles between aligned homologs. During Caenorhabditis elegans meiosis, central region components of the SC (SYP proteins) are essential to repair double-stran...
Benedetto, Alexandre Bambade, Timothée Au, Catherine Tullet, Jennifer M A Monkhouse, Jennifer Dang, Hairuo Cetnar, Kalina Chan, Brian Cabreiro, Filipe Gems, David
...
Published in
Aging cell
Caenorhabditis elegans is an excellent model for high-throughput experimental approaches but lacks an automated means to pinpoint time of death during survival assays over a short time frame, that is, easy to implement, highly scalable, robust, and versatile. Here, we describe an automated, label-free, high-throughput method using death-associated ...
Gershkovich, Miron Mikhailowitsch Groß, Victoria Elisabeth Kaiser, Anette Prömel, Simone
Published in
Cell Communication and Signaling
BackgroundThe neuropeptide Y system affects various processes, among others food intake, and is frequently discussed in the context of targeting obesity. Studies in model organisms are indispensable to enable molecular studies in a physiological context. Although the NPY system is evolutionarily conserved in all bilaterians, in the widely used mode...
Wu, An-Guo Teng, Jin-Feng Wong, Vincent Kam-Wai Zhou, Xiao-Gang Qiu, Wen-Qiao Tang, Yong Wu, Jian-Ming Xiong, Rui Pan, Rong Wang, Yi-Ling
...
Published in
Phytomedicine : international journal of phytotherapy and phytopharmacology
Emerging evidences indicate the important roles of autophagy in anti-oxidative stress, which is closely associated with cancer, aging and neurodegeneration. In the current study, we aimed to identify autophagy inducers with potent anti-oxidative effect from traditional Chinese medicines (TCMs) in PC-12 cells and C. elegans. The autophagy inducers w...
Zhang, Jingyan Li, Xuhang Olmedo, Maria Holdorf, Amy D. Shang, Ye Artal-Sanz, Marta Yilmaz, L. Safak Walhout, Albertha J. M.
Iron is an essential micronutrient for all forms of life; low levels of iron cause human disease, while too much iron is toxic. Low iron levels induce reactive oxygen species (ROS) by disruption of the heme and iron-sulfur cluster-dependent electron transport chain (ETC). To identify bacterial metabolites that affect development, we screened the Ke...
Chelo, Ivo M Afonso, Bruno Carvalho, Sara Theologidis, Ioannis Goy, Christine Pino-Querido, Ania Proulx, Stephen R Teotónio, Henrique
Published in
G3 (Bethesda, Md.)
Partial selfing, whereby self- and cross- fertilization occur in populations at intermediate frequencies, is generally thought to be evolutionarily unstable. Yet, it is found in natural populations. This could be explained if populations with partial selfing are able to reduce genetic loads and the possibility for inbreeding depression while keepin...
