Wei, Gang Sun, Honglin Liu, Jun-li Dong, Kai Liu, Junli Zhang, Min
Published in
Nutrition & Metabolism
BackgroundObesity occurs when the body’s energy intake is constantly greater than its energy consumption and the pharmacological enhancing the activity of brown adipose tissue (BAT) and (or) browning of white adipose tissue (WAT) has been considered promising strategies to treat obesity.MethodsIn this study, we took a multi-pronged approach to scre...
Zhou, Hongyi Xu, Cheng Lee, Hakjoo Yoon, Yisang Chen, Weiqin
Published in
Molecular Metabolism
• Mature BAT-specific loss of BSCL2 (Bscl2UCP1-BKO) activates SNS-independent cAMP/PKA signaling. • Bscl2UCP1-BKO increases BAT mitochondrial fission and uncoupling. • Bscl2UCP1-BKO reduces plasma triglyceride but not adiposity under thermoneutrality or high fat diet. • Bscl2UCP1-BKO blunts BAT reprograming and causes cold intolerance. • BSCL2 dele...
Gibert-Ramos, Albert Palacios-Jordan, Hector Salvadó, M Josepa Crescenti, Anna
Published in
European journal of nutrition
According to the xenohormesis theory, animals receive signals from plants that give clues about the changing environment, and thus, depending on the season of the year, animals develop physiological changes to adapt in advance to the seasonal changes. Our objective was to study how the same fruit cultivated during two different seasons could affect...
Wu, Wen-Chi Inui, Akio Chen, Chih-Yen
Published in
World Journal of Diabetes
The prevalence of overweight and obesity has increased worldwide. Obesity is a well-known risk factor of type 2 diabetes mellitus and cardiovascular disease and raises public health concerns. Many dietary guidelines encourage the replacement of refined grains with whole grains (WGs) to enhance body weight management. Current evidence regarding inte...
Soundarrajan, Malini Deng, Jie Kwasny, Mary Rubert, Nicholas C. Nelson, Paige C. El-Seoud, Dalya A. Landsberg, Lewis Neff, Lisa M.
Published in
Adipocyte
Objective : To explore relationships between PET/CT characteristics of cold-activated brown adipose tissue (BAT), measures of adiposity and metabolic markers. Methods : We conducted a post-hoc analysis of a study which utilized PET/CT to characterize BAT. 25 men ages 18–24 (BMI 19.4 to 35.9 kg/m2) were studied. Fasting blood samples were collected....
Ginzac, Angeline Barres, Bertrand Chanchou, Marion Gadéa, Emilie Molnar, Ioana Merlin, Charles Coudert, Bruno Thivat, Emilie Durando, Xavier
Published in
BMC Cancer
BackgroundA decrease in thermogenesis is suspected to be implicated in the energy expenditure reduction during breast cancer treatment. This study aimed to investigate the impact of chemotherapy on the metabolic activity of brown adipose tissue (BAT) and the link with weight variation.MethodsThis was an ancillary analysis of a multicentre trial inv...
Li, Ping Fan, Cunxia Cai, Yingying Fang, Shu Zeng, Yanmei Zhang, Yudan Lin, Xiaochun Zhang, Hongbin Xue, Yaoming Guan, Meiping
...
Published in
Adipocyte
Nonalcoholic fatty liver disease (NAFLD), main cause of liver damage, is inextricably linked to diabetes. However, there is no specific means to improve the pathology of fatty liver in diabetic patients. Brown adipose tissue (BAT) is an important endocrine organ that secretes adipokines and microRNAs (miRNAs) involved in systemic metabolic regulati...
ter Voert, Edwin E. G. W. Svirydenka, Hanna Müller, Julian Becker, Anton S. Balaz, Miroslav Efthymiou, Vissarion Maushart, Claudia Irene Gashi, Gani Wolfrum, Christian Betz, Matthias J.
...
Published in
EJNMMI Research
BackgroundPositron emission tomography (PET) is increasingly applied for in vivo brown adipose tissue (BAT) research in healthy volunteers. To limit the radiation exposure, the injected 18F-FDG tracer dose should be as low as possible. With simultaneous PET/MR imaging, the radiation exposure due to computed tomography (CT) can be avoided, but more ...
Riuzzi, Francesca Chiappalupi, Sara Arcuri, Cataldo Giambanco, Ileana Sorci, Guglielmo Donato, Rosario
Published in
Cellular and molecular life sciences : CMLS
Obesity is an endemic pathophysiological condition and a comorbidity associated with hypercholesterolemia, hypertension, cardiovascular disease, type 2 diabetes mellitus, and cancer. The adipose tissue of obese subjects shows hypertrophic adipocytes, adipocyte hyperplasia, and chronic low-grade inflammation. S100 proteins are Ca2+-binding proteins ...
Gachkar, Sogol Oelkrug, Rebecca Herrmann, Beate Scanlan, Thomas S. Sun, Qian Biebermann, Heike Hoefig, Carolin S. Schomburg, Lutz Mittag, Jens
Published in
European Thyroid Journal
Introduction: Injection of 3-iodothyronamine into experimental animals profoundly affects their metabolism and body temperature. As 3-iodothyronamine is rapidly acetylated in vivo after injection, it was hypothesized that the metabolites N- or O-acetyl-3-iodothyronamines could constitute the active hormones. Methods: Adult male mice were injected o...
