Raposo, Helena F Forsythe, Patricia Chausse, Bruno Castelli, Júlia Z Moraes-Vieira, Pedro M Nunes, Valéria S Oliveira, Helena C F
Published in
Metabolism: clinical and experimental
The systemic function of CETP has been well characterized. CETP plasma activity reduces HDL cholesterol and thus increases the risk of atherosclerosis. Here, we investigated whether CETP expression modulate adiposity. Body adiposity and energy metabolism related assays and gene/protein expression were compared in CETP transgenic and non-transgenic ...
Escalona-Garrido, Carmen Vázquez, Patricia Mera, Paula Zagmutt, Sebastián García-Casarrubios, Ester Montero-Pedrazuela, Ana Rey-Stolle, Fernanda Guadaño-Ferraz, Ana Rupérez, Francisco J Serra, Dolors
...
Published in
Molecular metabolism
Metainflammation is a chronic low-grade inflammatory state induced by obesity and associated comorbidities, including peripheral insulin resistance. Brown adipose tissue (BAT), a therapeutic target against obesity, is an insulin target tissue sensitive to inflammation. Therefore, it is necessary to find strategies to protect BAT against the effects...
McHugh, Christian T. Garside, John Barkes, Jared Frank, Jonathan Dragicevich, Constance Yuan, Hong Branca, Rosa T.
Published in
EJNMMI Research
BackgroundBrown adipose tissue (BAT) is a fat tissue found in most mammals that helps regulate energy balance and core body temperature through a sympathetic process known as non-shivering thermogenesis. BAT activity is commonly detected and quantified in [18F]FDG positron emission tomography/computed tomography (PET/CT) scans, and radiotracer upta...
Paulus, Andreas Drude, Natascha van Marken Lichtenbelt, Wouter Mottaghy, Felix M. Bauwens, Matthias
Published in
EJNMMI Research
BackgroundIn vivo imaging of glucose analogue 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) via positron emission tomography (PET) is the current gold standard to visualize and assess brown adipose tissue (BAT) activity. However, glucose metabolism is only a part of the metabolic activity of BAT. [18F]FDG-PET has been shown in clinical trials to often...
Horii, Yuko Fujisaki, Yoshiyuki Misonou, Yoshiko Fuyuki, Risa Nagai, Katsuya
Published in
Neuroscience letters
The autonomic nervous system (ANS) is implicated in maintaining homeostasis of the internal environment in mammals. Therefore, changes occurring in the ANS can cause alterations of physiological phenomena. Ethyl hexanoate (EH) is known as the aroma component of apples. To study the action of ethyl hexanoate on physiological phenomena, we examined t...
Pace, Nikolai Paul Vassallo, Josanne Calleja-Agius, Jean
Published in
Early human development
Gestational diabetes (GDM) is a common metabolic complication of pregnancy that is generally asymptomatic in its clinical course, although it is potentially associated with a wide range of both maternal and foetal complications. The population prevalence of GDM varies widely, depending on the clinical diagnostic criteria, ethnicity, demographics an...
Fenzl, Anna Kulterer, Oana Cristina Spirk, Katrin Mitulović, Goran Marculescu, Rodrig Bilban, Martin Baumgartner-Parzer, Sabina Kautzky-Willer, Alexandra Kenner, Lukas Plutzky, Jorge
...
Published in
Molecular Metabolism
Objective Transformation of white into brown fat (“browning”) reduces obesity in many preclinical models and holds great promise as a therapeutic concept in metabolic disease. Vitamin A metabolites (retinoids) have been linked to thermogenic programming of adipose tissue; however, the physiologic importance of systemic retinoid transport for adipos...
Prídavková, Dana Samoš, Matej Kyčina, Roman Adamicová, Katarína Kalman, Michal Belicová, Margita Mokáň, Marián
Published in
World Journal of Clinical Cases
BACKGROUND Insulinomas are the most common type of functioning endocrine neoplasms of the pancreas presenting hypoglycemic symptoms. Patients characteristically develop symptoms while fasting, but some patients have reported symptoms only in the postprandial state. Repeated and prolonged hypoglycemic episodes can reduce the awareness of adrenergic ...
Halpern, Bruno Mancini, Marcio C. Mendes, Caroline Machado, Camila Maria Longo Prando, Silvana Sapienza, Marcelo Tatit Buchpiguel, Carlos Alberto do Amaral, Fernanda Gaspar Cipolla-Neto, José
Published in
Diabetology & Metabolic Syndrome
ObjectiveMelatonin has been shown to increase brown adipose tissue (BAT) mass, which can lead to important metabolic effects, such as bodyweight reduction and glycemic improvement. However, BAT mass can only be measured invasively and. The gold standard for non-invasive measurement of BAT activity is positron emission tomography with 2-deoxy-2-[flu...
Son, Yeonho Cho, Yoon Keun Saha, Abhirup Kwon, Hyun-Jung Park, Ji-Hyun Kim, Minsu Jung, Young-Suk Kim, Sang-Nam Choi, Cheoljun Seong, Je-Kyung
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Published in
Molecular metabolism
Beclin1 is a core molecule of the macroautophagy machinery. Although dysregulation of macroautophagy is known to be involved in metabolic disorders, the function of Beclin1 in adipocyte metabolism has not been investigated. In the present study, we aimed to study the role of Beclin1 in lipolysis and mitochondrial homeostasis of adipocytes. Autophag...
