Hitrec, Timna Squarcio, Fabio Piscitiello, Emiliana Cerri, Matteo Martelli, Davide Occhinegro, Alessandra Taddei, Ludovico Tupone, Domenico Amici, Roberto Luppi, Marco
...
Published in
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology
Neuronal Tau protein hyperphosphorylation (PPtau) is a hallmark of tauopathic neurodegeneration. However, a reversible brain PPtau occurs in mammals during either natural or "synthetic" torpor (ST), a transient deep hypothermic state that can be pharmacologically induced in rats. Since in both conditions a high sleep pressure builds up during the r...
Idris, Zamzuri Yee, Ang Song Wan Hassan, Wan Mohd Nazaruddin Hassan, Mohamad Hasyizan Ab Mukmin, Laila Mohamed Zain, Khairu Anuar Manaf, Asrulnizam Abd Balandong, Rodney Petrus Tang, Tong Boon
Published in
Surgical Neurology International
Background: Brain cooling therapy is one of the subjects of interest, and currently, data on direct brain cooling are lacking. Hence, the objective is to investigate the clinical outcomes and discuss the thermodynamics aspect of direct brain cooling on severely injured brain patients. Methods: This pilot study recruited the severely injured brain p...
Plank, Julia R Morgan, Catherine Sundram, Frederick Plank, Lindsay D Hoeh, Nicholas Ahn, Sinyeob Muthukumaraswamy, Suresh Lin, Joanne C
Published in
NeuroImage. Clinical
Prior studies indicate a pathogenic role of neuroinflammation in psychiatric disorders; however, there are no accepted methods that can reliably measure low-level neuroinflammation non-invasively in these individuals. Magnetic resonance spectroscopic imaging (MRSI) is a versatile, non-invasive neuroimaging technique that demonstrates sensitivity to...
Shevelev, Oleg Petrova, Marina Smolensky, Andrey Osmonov, Batyr Toimatov, Samatbek Kharybina, Tatyana Karbainov, Sergey Ovchinnikov, Lev Vesnin, Sergey Tarakanov, Alexander
...
Published in
Drug discovery today
Brain temperature (BT) is a crucial physiological parameter used to monitor cerebral status. Physical activities and traumatic brain injuries (TBI) can affect BT; therefore, non-invasive BT monitoring is an important way to gain insight into TBI, stroke, and wellbeing. The effects of BT on physical performance have been studied at length. When huma...
Mueller, Christina Baird, Jessica F. Motl, Robert W.
Published in
Neurorehabilitation and neural repair
Background: Older adults with multiple sclerosis (MS) experience mobility impairments, but conventional brain imaging is a poor predictor of walking abilities in this population. Objective: To test whether brain metabolites measured with Magnetic Resonance Spectroscopy (MRS) are associated with walking performance in older adults with MS. Methods: ...
Ungurean, Gianina
Sleep is a ubiquitous behavior found in all animals studied to date, from jellyfish to humans. In mammals, sleep can be divided into two major states, non-rapid eye movement (NREM) sleep and REM sleep based on brain electrophysiological signatures and behavior. Although important advances have been made in the past decades in our understanding of t...
Ungurean, Gianina
Sleep is a ubiquitous behavior found in all animals studied to date, from jellyfish to humans. In mammals, sleep can be divided into two major states, non-rapid eye movement (NREM) sleep and REM sleep based on brain electrophysiological signatures and behavior. Although important advances have been made in the past decades in our understanding of t...
Lee, Choongheon Jones, Timothy A
Published in
Journal of the Association for Research in Otolaryngology : JARO
Management of vestibular dysfunction may include treatment with medications that are thought to act to suppress vestibular function and reduce or eliminate abnormal sensitivity to head motions. The extent to which vestibular medications act centrally or peripherally is still debated. In this study, two commonly prescribed medications, meclizine and...
Thomas, Shruthi A Curay, Carlos M Kiyatkin, Eugene A
Published in
Neuropharmacology
Alcohol is the most commonly used psychoactive drug, often taken in conjunction with opioid drugs. Since both alcohol and opioids can induce CNS depression, it is often assumed that alcohol potentiates the known hypoxic effects of opioid drugs. To address this supposition, we used oxygen sensors to examine the effects of alcohol on brain oxygenatio...
Kiyatkin, Eugene A
Published in
Journal of integrative neuroscience
Peripheral vasoconstriction is a centrally mediated physiological effect known to play an important role in regulating body temperature by adjusting heat exchange with the external environment. However, peripheral vasoconstriction as a component of sympathetic activation also occurs following exposure to various salient stimuli and during motivated...
