Babey, Muriel E Krause, William C Chen, Kun Herber, Candice B Torok, Zsofia Nikkanen, Joni Rodriguez, Ruben Zhang, Xiao Castro-Navarro, Fernanda Wang, Yuting
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In lactating mothers, the high calcium (Ca2+) demand for milk production triggers significant bone loss1. Although oestrogen normally counteracts excessive bone resorption by promoting bone formation, this sex steroid drops precipitously during this postpartum period. Here we report that brain-derived cellular communication network factor 3 (CCN3) ...
Schurman, Charles Kaya, Serra Dole, Neha Luna, Nadja Castillo, Natalia Potter, Ryan Rose, Jacob Bons, Joanna King, Christina Burton, Jordan
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Poor bone quality is a major factor in skeletal fragility in elderly individuals. The molecular mechanisms that establish and maintain bone quality, independent of bone mass, are unknown but are thought to be primarily determined by osteocytes. We hypothesize that the age-related decline in bone quality results from the suppression of osteocyte per...
Sieverts, Michael Yee, Cristal Nemani, Minali Parkinson, Dilworth Y Alliston, Tamara Acevedo, Claire
Osteocytes locally remodel their surrounding tissue through perilacunar canalicular remodeling (PLR). During lactation, osteocytes remove minerals to satisfy the metabolic demand, resulting in increased lacunar volume, quantifiable with synchrotron X-ray radiation micro-tomography (SRµCT). Although the effects of lactation on PLR are well-studied, ...
Stylianou, Chrysovalantis Deftereos, Savas
Published in
Acta medica academica
Nabwire, Florence Hamill, Matthew M Fowler, Mary Glenn Byamugisha, Josaphat Kekitiinwa, Adeodata Prentice, Ann
Funder: Alborada Trust; doi: http://dx.doi.org/10.13039/100008288 / Funder: Department of International Development / Funder: Gates Cambridge Trust; doi: http://dx.doi.org/10.13039/501100005370 / Funder: Medical Research Council / We reported accentuated lactational decreases in areal bone mineral density and only partial skeletal recovery after la...
Yuan, Xue Amin, Vedanshi Zhu, Tianli Kittaka, Mizuho Ueki, Yasuyoshi Bellido, Teresita M Turkkahraman, Hakan
Published in
Journal of periodontology
Type 1 diabetes mellitus (T1DM) and periodontitis have long been thought to be biologically connected. Indeed, T1DM is a risk factor for periodontal disease. With the population of diabetic individuals growing, it is more important than ever to understand the negative consequences of diabetes on the periodontium and the mechanisms. The aim of this ...
Huybrechts, Yentl Evenepoel, Pieter Haarhaus, Mathias Cavalier, Etienne Dams, Geert Van Hul, Wim D'Haese, Patrick C Verhulst, Anja
peer reviewed / Renal osteodystrophy (ROD) is a complex and serious complication of chronic kidney disease (CKD), a major global health problem caused by loss of renal function. Currently, the gold standard to accurately diagnose ROD is based on quantitative histomorphometric analysis of trabecular bone. Although this analysis encompasses the evalu...
Gizaw, Andinet King, Wendy Hinerman, Amanda Chung, Raymond Lisker-Melman, Mauricio Ghany, Marc Khalili, Mandana Jain, Mamta Graham, Jacob Swift-Scanlan, Theresa
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OBJECTIVE: Tenofovir disoproxil fumarate (TDF) is a common component of antiretroviral therapy in hepatitis B virus (HBV)-HIV co-infected adults but few studies have evaluated worsening renal function and bone turnover, known effects of TDF. METHODS: Adults from eight North American sites were enrolled in this cohort study. Research assessments wer...
Shaffer, Sarah K Stover, Susan M Fyhrie, David P
Focal bone lesions are often found prior to clinically relevant stress-fractures. Lesions are characterized by low bone volume fraction, low mineral density, and high levels of microdamage and are hypothesized to develop when bone tissue cannot sufficiently respond to damaging loading. It is difficult to determine how exercise drives the formation ...
Printzi, A. Mazurais, D. Witten, Paul Eckhard Madec, L. Gonzalez, A.-A. Mialhe, X. Zambonino-Infante, J.-L. Koumoundouros, G.
Haemal lordosis, a frequent skeletal deformity in teleost fish, has long been correlated with increased mechanical loads induced by swimming activity. In the present study, we examine whether juvenile zebrafish can recover from haemal lordosis and explore the musculoskeletal mechanisms involved. Juveniles were subjected to a swimming challenge test...