Han, Yang Gao, Chunhong Wang, Hao Sun, Jiejie Liang, Meng Feng, Ye Liu, Qianqian Fu, Shiyao Cui, Lin Gao, Chunsheng
...
Published in
Bioactive materials
Neuronal mitochondrial dysfunction caused by excessive reactive oxygen species (ROS) is an early event of sporadic Alzheimer's disease (AD), and considered to be a key pathologic factor in the progression of AD. The targeted delivery of the antioxidants to mitochondria of injured neurons in brain is a promising therapeutic strategy for AD. A safe a...
Manrique-Suárez, Viana Vispo, Nelson Santiago Ramos, Oliberto Sánchez
Published in
Current pharmaceutical biotechnology
The main obstacle to biopharmaceutical delivery in therapeutic concentration into the brain for treating neurological disorders is the presence of the blood-brain barrier (BBB). The physiological process of receptor-mediated transcytosis (RMT) to transport cargo through the brain endothelial cells toward brain parenchyma has prompted researchers to...
Yap, Chris Short, Jennifer L Nicolazzo, Joseph A
Published in
Journal of pharmaceutical sciences
Modulating the abundance of the blood-brain barrier (BBB) efflux transporter breast cancer resistance protein (BCRP) has the potential to impact brain levels of drugs and endogenous substrates. Studies have demonstrated that the metal ionophore clioquinol (CQ) increases BBB abundance of P-glycoprotein (P-gp), an effect associated with increased end...
Stavarache, Mihaela A Chazen, J Levi Kaplitt, Michael G
Published in
World neurosurgery
Magnetic resonance-guided focused ultrasound (MRgFUS) is a cutting-edge technology that is changing the practice of movement disorders surgery. Given the noninvasive and innovative nature of this technology, there is great interest in expanding the use of MRgFUS to additional diseases and applications. Current approved applications target the motor...
Benmimoun, Billel Papastefanaki, Florentia Périchon, Bruno Segklia, Katerina Roby, Nicolas Miriagou, Vivi Schmitt, Christine Dramsi, Shaynoor Matsas, Rebecca Spéder, Pauline
...
Published in
Nature Communications
Bacterial and fungal pathogens that cross the blood-brain-barrier (BBB) can cause severe disease. Here, Benmimoun et al. develop a model to study BBB crossing in the developing Drosophila brain and discover Group B Streptococcus factors important for BBB crossing and virulence, one of which, a lipoprotein, they confirm in mice.
Zeitelhofer, Manuel Adzemovic, Milena Z. Moessinger, Christine Stefanitsch, Christina Strell, Carina Muhl, Lars Brundin, Lou Fredriksson, Linda Olsson, Tomas Eriksson, Ulf
...
Published in
Scientific Reports
Disruption of blood–brain barrier (BBB) integrity is a feature of various neurological disorders. Here we found that the BBB is differently affected during the preclinical, progression and remission phase of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). We have identified an upregulation of pro-inflamm...
Mohammadi, Parnian Mahjub, Reza Mohammadi, Mojdeh Derakhshandeh, Katayoun Ghaleiha, Ali Mahboobian, Mohammad Mehdi
Published in
Drug development and industrial pharmacy
Perphenazine (PPZ) is a typical antipsychotic that is mainly administrated for the treatment of schizophrenia. Due to its highly lipophilic nature and extensive hepatic first-pass metabolism, its oral bioavailability is low (40%). The novel nanocarriers like solid lipid nanoparticles (SLN) have been reported to be highly effective for improving the...
Matsui, Toshiro Yoshino, Atsuko Tanaka, Mitsuru
Published in
Food Production, Processing and Nutrition
AbstractDietary di/tripeptides elicit preventive effects against lifestyle-related diseases such as hypertension, and hypercholesterolemia, etc. Although there have been evidential reports that the intake of protein hydrolysate improved impaired memory in human, limited studies on bioavailability, in particular, beyond the blood-brain barrier (BBB)...
Figarol, Agathe Piantino, Marie Furihata, Tomomi Satoh, Taku Sugiura, Shinji Kanamori, Toshiyuki Matsusaki, Michiya
Published in
Biochemical and biophysical research communications
Cell culture under medium flow has been shown to favor human brain microvascular endothelial cells function and maturation. Here a three-dimensional in vitro model of the human brain microvasculature, comprising brain microvascular endothelial cells but also astrocytes, pericytes and a collagen type I microfiber - fibrin based matrix, was cultured ...
McMahon, Dallan Lassus, Anne Gaud, Emmanuel Jeannot, Victor Hynynen, Kullervo
Published in
Scientific Reports
Focused ultrasound and microbubble (FUS + MB)-mediated blood–brain barrier (BBB) permeability enhancement can facilitate targeted brain-drug delivery. While controlling the magnitude of BBB permeability enhancement is necessary to limit tissue damage, little work has attempted to decouple these concepts. This work investigated the relationship betw...
