Cánovas-Serrano, Yaiza Vallés-San-Leandro, Lorenzo Rodríguez-Izquierdo, Miguel Ángel López-Serrano, Rafael Lajara-Blesa, Jerónimo
Published in
Journal of optometry
To corroborate whether vessels on the surface of the optic nerve head can provide protection against the loss of underlying axons in subjects with manifest glaucoma. In this pilot study, thirty-six glaucomatous eyes with a perimetric defect in the Bjerrum area were included. The retinal nerve fiber layer (RNFL) thickness was measured in each of the...
Hattori, Yuki
Published in
Neuroscience research
Microglia are the immune cells in the central nervous system (CNS). Once microglial progenitors are generated in the yolk sac, these cells enter the CNS and colonize its structures by migrating and proliferating during development. Although the microglial population in the CNS is still low in this stage compared to adults, these cells can associate...
Ahn, Joongho Baik, Jin Woo Kim, Yeonggeon Choi, Karam Park, Jeongwoo Kim, Hyojin Kim, Jin Young Kim, Hyung Ham Nam, Sung Hyun Kim, Chulhong
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Published in
Photoacoustics
Photoacoustic microscopy (PAM) is used to visualize blood vessels and to monitor their time-dependent changes. Photoplethysmography (PPG) measures hemodynamic time-series changes such as heart rate. However, PPG's limited visual access to the dynamic changes of blood vessels has prohibited further understanding of hemodynamics. Here, we propose a n...
Maruoka, Haruhi Hasegawa, Tomoka Yoshino, Hirona Abe, Miki Haraguchi-Kitakamae, Mai Yamamoto, Tomomaya Hongo, Hiromi Nakanishi, Ko Nasoori, Alireza Nakajima, Yuhi
...
Published in
Journal of oral biosciences
Recently, the biological functions of endomucin-positive blood vessels and closely associated αSMA-positive cells in long bones have been highlighted. The surrounding tissues of the flat bones, such as nasal bones covered with mucosa and lamina propria, are different from those of the long bones, indicating the different distributions of endomucin-...
Abernethie, Amber J Gastaldello, Annalisa Maltese, Giorgia Morgan, Ruth A McInnes, Kerry J Small, Gary R Walker, Brian R Livingstone, Dawn Ew Hadoke, Patrick Wf Andrew, Ruth
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Published in
European journal of pharmacology
5α-Tetrahydrocorticosterone (5αTHB) is an effective topical anti-inflammatory agent in mouse, with less propensity to cause skin thinning and impede new blood vessel growth compared with corticosterone. Its anti-inflammatory effects were not prevented by RU38486, a glucocorticoid receptor antagonist, suggesting alternative mechanisms. The hypothesi...
Ni, Nengyi Wang, Weiyi Sun, Yu Sun, Xiao Leong, David Tai
Published in
Biomaterials
All intravenous delivered nanomedicine needs to escape from the blood vessel to exert their therapeutic efficacy at their designated site of action. Failure to do so increases the possibility of detrimental side effects and negates their therapeutic intent. Many powerful anticancer nanomedicine strategies rely solely on the tumor derived enhanced p...
Munadziroh, Elly Askandar, Muhammad Genadi Yuliati, Anita Surboyo, Meircurius Dwi Condro Wan Harun, Wan Himratul Aznita
Published in
Journal of Oral Biology and Craniofacial Research
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Leonard, Elvin V Figueroa, Ricardo J Bussmann, Jeroen Lawson, Nathan D Amigo, Julio D Siekmann, Arndt F
Published in
Development (Cambridge, England)
Vascular networks comprise endothelial cells and mural cells, which include pericytes and smooth muscle cells. To elucidate the mechanisms controlling mural cell recruitment during development and tissue regeneration, we studied zebrafish caudal fin arteries. Mural cells colonizing arteries proximal to the body wrapped around them, whereas those in...
Peral, Assumpta Mateo, Jesús Domínguez-Godínez, Carmen O Carracedo, Gonzalo Gómez, Jose Antonio Crooke, Almudena Pintor, Jesús
Published in
Experimental eye research
Given the implications of the problem of neovascularization on ocular health, as well as the growth in the number of cases, the purpose of the present study has been testing the efficacy of siRNAs (small interfering RNA) designed to silence Hypoxia Inducible Factor -1α (HIF-1α) and to demonstrate that their use stops neovascularization in a model o...
Wang, Jingchao Zhang, Hongpeng Ji, Jing Wang, Lixuan Lv, Wenxin He, Yuan Li, Xuan Feng, Guangyu Chen, Kinon
Published in
Heliyon
This study investigated the pathogenesis of age-related macular degeneration (AMD) using histological methods that are commonly used for atherosclerotic vascular disease (ASVD). 1 normal, 3 early dry AMD, and 1 late dry AMD eyes were obtained from the Lions Eye Bank of Oregon and systematically dissected. They were stained with hematoxylin and eosi...