Khatun, Ayesha Paterson, Ross W. Schöll, Michael
Published in
Alzheimer's Research & Therapy
Biomarkers are increasingly employed for effective research into neurodegenerative diseases. They have become essential for reaching an accurate clinical diagnosis, monitoring disease, and refining entry criteria for participation in clinical treatment trials, and will be key in measuring target engagement and treatment outcome in disease-modifying...
Li, Danni Mielke, Michelle M. Bell, W. Robert Reilly, Cavan Zhang, Lin Lin, Feng Vankee Yu, Fang
Published in
Trials
BackgroundAlzheimer’s disease (AD) is an epidemic with tremendous public health impacts because there are currently no disease-modifying therapeutics. Randomized controlled trials (RCTs) for prevention of AD dementia often use clinical endpoints that take years to manifest (e.g., cognition) or surrogate endpoints that are costly or invasive (e.g., ...
Thomas, Ilias Dickens, Alex M. Posti, Jussi P. Mohammadian, Mehrbod Ledig, Christian Takala, Riikka S. K. Hyötyläinen, Tuulia Tenovuo, Olli Oresic, Matej
Recent evidence suggests that patients with traumatic brain injuries (TBIs) have a distinct circulating metabolic profile. However, it is unclear if this metabolomic profile corresponds to changes in brain morphology as observed by magnetic resonance imaging (MRI). The aim of this study was to explore how circulating serum metabolites, following TB...
Li, Danni Mielke, Michelle M.
Published in
Neurology and Therapy
The development of blood-based biomarkers of Alzheimer’s disease (AD) pathology as tools for screening the general population, and as the first step in a multistep process to determine which non-demented individuals are at greatest risk of developing AD dementia, is essential. Proteins that are reflective of AD pathology, such as amyloid beta 42 (A...
Risacher, Shannon L Fandos, Noelia Romero, Judith Sherriff, Ian Pesini, Pedro Saykin, Andrew J Apostolova, Liana G
Published in
Alzheimer's & dementia (Amsterdam, Netherlands)
We investigated the relationship of plasma amyloid beta (Aβ) with cerebral deposition of Aβ and tau on positron emission tomography (PET). Forty-four participants (18 cognitively normal older adults [CN], 10 mild cognitive impairment, 16 Alzheimer's disease [AD]) underwent amyloid PET and a blood draw. Free and total plasma Aβ40 and Aβ42 were asses...
Manzano-Crespo, Marta Atienza, Mercedes Cantero, Jose L.
Published in
Translational Neurodegeneration
BackgroundPrevious studies have shown that expression levels of miR-181c are downregulated by amyloid-β (Aβ) deposition and chronic cerebral hypoperfusion, both factors largely associated with the development of AD. Moreover, reduced 2-[18F]fluoro-2-deoxy-D-glucose (FDG)-PET brain metabolism and volume loss of regions of the medial temporal lobe ha...
Gregory, Michael A. Manuel-Apolinar, Leticia Sánchez-Garcia, Sergio Villa Romero, Antonio R. de Jesús Iuit Rivera, Jaime Basurto Acevedo, Lourdes Grijalva-Otero, Israel Cuadros-Moreno, Juan Garcia-de la Torre, Paola Guerrero Cantera, Jose
...
Published in
Dementia and Geriatric Cognitive Disorders
Background: Endothelial dysfunction and subsequent inflammation contribute to the development of vascular cognitive impairment (VCI). Soluble intercellular adhesion molecule-1 (sICAM-1) is upregulated in endothelial dysfunction and promotes an inflammatory response; however, the relationship between sICAM-1 and VCI remains equivocal. Objective: To ...
Staudt, Amanda M. Whitworth, Kristina W. Chien, Lung-Chang Whitehead, Lawrence W. Gimeno Ruiz de Porras, David
Published in
International Archives of Occupational and Environmental Health
PurposeExposure to organic solvents and noise may be causal agents in the development of hearing loss and tinnitus. The objectives of the present study were to examine the association of organic solvents with hearing loss and tinnitus and to assess the interaction of organic solvent and occupational noise exposure on hearing loss and tinnitus.Metho...
Ashton, Nicholas J. Leuzy, Antoine Lim, Yau Mun Troakes, Claire Hortobágyi, Tibor Höglund, Kina Aarsland, Dag Lovestone, Simon Schöll, Michael Blennow, Kaj
...
Published in
Acta Neuropathologica Communications
Alzheimer’s disease (AD) is pathologically characterized by the accumulation of amyloid-β (Aβ) plaques, neurofibrillary tangles and widespread neuronal loss in the brain. In recent years, blood biomarkers have emerged as a realistic prospect to highlight accumulating pathology for secondary prevention trials. Neurofilament light chain (NfL), a mark...
Soria, Francesco Krabbe, Laura-Maria Todenhöfer, Tilman Dobruch, Jakub Mitra, Anirban P. Inman, Brant A. Gust, Kilian M. Lotan, Yair Shariat, Shahrokh F.
Published in
World Journal of Urology
PurposeUse of molecular markers in urine, tissue or blood offers potential opportunities to improve understanding of bladder cancer biology which may help identify disease earlier, risk stratify patients, improve prediction of outcomes or help target therapy.MethodsA review of the published literature was performed, without restriction of time.Resu...
