Kepchia, Devin Huang, Ling Currais, Antonio Liang, Zhibin Fischer, Wolfgang Maher, Pamela
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
J147 is a novel drug candidate developed to treat neurological dysfunction. Numerous studies have demonstrated the beneficial effects of J147 in cellular and animal models of disease which has led to the transitioning of the compound into human clinical trials. However, no biomarkers for its target engagement have been identified. Here, we determin...
De With, Ruben R Artola Arita, Vicente Nguyen, Bao-Oanh Linz, Dominik Ten Cate, Hugo Spronk, Henri Schotten, Ulrich Jan van Zonneveld, Anton Erküner, Ömer Bayón, M Agustina
...
Published in
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
The clinical risk profile of atrial fibrillation (AF) patients is different in men and women. Our aim was to identify sex differences in blood biomarkers in patients with paroxysmal AF. Sex differences in 92 blood biomarkers were measured in 364 patients included in our discovery cohort, the identification of a risk profile to guide atrial fibrilla...
Oldfield, Lucy Evans, Anthony Rao, Rohith Gopala Jenkinson, Claire Purewal, Tejpal Psarelli, Eftychia E. Menon, Usha Timms, John F. Pereira, Stephen P. Ghaneh, Paula
...
Published in
EBioMedicine
Background Screening for pancreatic ductal adenocarcinoma (PDAC) in populations at high risk is recommended. Individuals with new-onset type 2 diabetes mellitus (NOD) are the largest high-risk group for PDAC. To facilitate screening, we sought biomarkers capable of stratifying NOD subjects into those with type 2 diabetes mellitus (T2DM) and those w...
Bayoumy, Sherif Verberk, Inge M. W. den Dulk, Ben Hussainali, Zulaiga Zwan, Marissa van der Flier, Wiesje M. Ashton, Nicholas J. Zetterberg, Henrik Blennow, Kaj Vanbrabant, Jeroen
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Published in
Alzheimer's Research & Therapy
IntroductionStudies using different assays and technologies showed highly promising diagnostic value of plasma phosphorylated (P-)tau levels for Alzheimer’s disease (AD). We aimed to compare six P-tau Simoa assays, including three P-tau181 (Eli Lilly, ADx, Quanterix), one P-tau217 (Eli Lilly), and two P-tau231 (ADx, Gothenburg).MethodsWe studied th...
Cui, Shuangshuang Zhao, Likun Wang, Yumin Dong, Qiang Ma, Jianxiong Ma, Xinlong
Published in
Injury
Internal fixation is currently considered the gold standard in treatment for femoral neck fractures in adults. However, osteonecrosis of the femoral head (ONFH) after internal fixation would occur in quite proportion of patients with femoral neck fracture, even in Garden I femoral neck fracture. The purpose of this study was to determine the associ...
Huibregtse, Megan E Bazarian, Jeffrey J Shultz, Sandy R Kawata, Keisuke
Published in
Neuroscience and biobehavioral reviews
HUIBREGTSE, M.E, Bazarian, J.J., Shultz, S.R., and Kawata K. The biological significance and clinical utility of emerging blood biomarkers for traumatic brain injury. NEUROSCI BIOBEHAV REV XX (130) 433-447, 2021.- Blood biomarkers can serve as objective measures to gauge traumatic brain injury (TBI) severity, identify patients at risk for adverse o...
Petrovic, Dusan Marcus, Kailing Sandoval, José Cullati, Stéphane Piumatti, Giovanni Bodenmann, Patrick Jackson, Yves-Laurent Durosier Izart, Claire Wolff, Hans Guessous, Idris
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Published in
Preventive Medicine Reports
Forgoing healthcare for economic reasons has been previously associated with adverse health outcomes, including a higher risk of hospitalization, a lower quality of life, and worse self-reported health. However, the exact cause-to-effect relation between forgoing healthcare and health-related outcomes has been insufficiently described. Here, we inv...
Sun, Bo Zhang, Bo Guo, Xiang Liu, Wei-Hua Pang, Gui-Fen Yang, Lin-Ying Jiang, Feng Zhang, Qing
Published in
International journal of clinical and experimental pathology
Due to a continued increase in viral pneumonia incidence and resulting high mortality, fast and accurate diagnosis is important for effective management. This investigation examined the significance of blood biomarkers and the CT score in the early diagnosis of viral pneumonia. Patients who were hospitalized due to radiologically-confirmed pneumoni...
Hier, Daniel B. Obafemi-Ajayi, Tayo Thimgan, Matthew S. Olbricht, Gayla R. Azizi, Sima Allen, Blaine Hadi, Bassam A. Wunsch, Donald C. II
Published in
Biomarker Research
BackgroundThe use of blood biomarkers after mild traumatic brain injury (mTBI) has been widely studied. We have identified eight unresolved issues related to the use of five commonly investigated blood biomarkers: neurofilament light chain, ubiquitin carboxy-terminal hydrolase-L1, tau, S100B, and glial acidic fibrillary protein. We conducted a focu...
Moseby-Knappe, Marion Mattsson-Carlgren, Niklas Stammet, Pascal Backman, Sofia Blennow, Kaj Dankiewicz, Josef Friberg, Hans Hassager, Christian Horn, Janneke Kjaergaard, Jesper
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Published in
Intensive Care Medicine
Purpose The majority of unconscious patients after cardiac arrest (CA) do not fulfill guideline criteria for a likely poor outcome, their prognosis is considered “indeterminate”. We compared brain injury markers in blood for prediction of good outcome and for identifying false positive predictions of poor outcome as recommended by guidelines. Metho...
