Almazni, Ibrahim Chudakou, Pavel Dawson-Meadows, Alison Downes, Kate Freson, Kathleen Mason, Joanne Page, Paula Reay, Kim Myers, Bethan Morgan, Neil V
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Published in
Platelets
Familial Platelet Disorder with associated Myeloid Malignancy (FPDMM) is a rare inherited disorder confirmed with the presence of a pathogenic germline RUNX1 variant and is thought to be heavily underdiagnosed. RUNX1 has also been found to be mutated in up to 10% of adult AML cases and other cell malignancies. We performed targeted next-generation ...
Abdelmohsen, Mohsen Ahmed Alkandari, Buthaina M. Gupta, Vikash K. Elsebaie, Nermeen
Published in
Egyptian Journal of Radiology and Nuclear Medicine
BackgroundCorona virus disease 2019 (COVID-19) pandemic—as declared by the World Health Organization—is a major threatening public health problem. At the time of writing, more than 60,000,000 patients and more than 1,500,000 deaths were recorded worldwide.Besides the classical chest symptoms, gastrointestinal tract-related symptoms were noted, like...
Yung, D E Robertson, A R Davie, M Sidhu, R McAlindon, M Rahman, I Patel, P Sinha, L Mason, S Brzeszczynska, J
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Published in
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Capsule endoscopy (CE) is well established the investigation of small-bowel (SB) pathology. We compared the use of double-headed (DH) capsules, to conventional single-headed (SH), in a real-world patient cohort in the first multicentre British study. Over 9 months, patients referred for routine SBCE at 4 tertiary referral centres in the UK underwen...
Genovesi, Simonetta Porcu, Luca Slaviero, Giorgio Casu, Gavino Bertoli, Silvio Sagone, Antonio Buskermolen, Monique Pieruzzi, Federico Rovaris, Giovanni Montoli, Alberto
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Published in
Journal of nephrology
In patients with end stage renal disease and atrial fibrillation (AF), undergoing chronic dialysis, direct oral agents are contraindicated and warfarin does not fully prevent embolic events while increasing the bleeding risk. The high hemorrhagic risk represents the main problem in this population. Aim of the study was to estimate the safety and ef...
Nagata, Kohei Tajiri, Kazuto Muraishi, Nozomu Kobayashi, Saito Sibuya, Kazuto Yoshioka, Isaku Fujii, Tsutomu Tanaka, Shinichi Imura, Johji Yasuda, Ichiro
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Published in
Clinical journal of gastroenterology
Arteriovenous malformation (AVM) in the pancreas rarely causes acute pancreatitis. However, even when it does cause pancreatitis, the pathogenesis is unclear. A 61-year-old man was admitted to our hospital for acute pancreatitis. The findings of computed abdominal tomography, magnetic resonance imaging, and endoscopic ultrasonography revealed pancr...
Dahlberg, Sofia Schött, Ulf Kander, Thomas
Published in
Journal of Intensive Care
BackgroundPrevious studies have indicated that vitamin K deficiency is common in non-bleeding critically ill patients with slightly prolonged prothrombin time-international normalized ratio (PT-INR). It has never been investigated thoroughly whether the administration of vitamin K to these patients could affect their PT-INR. Therefore, the aim of t...
Komen, Joris J Forslund, Tomas Mantel-Teeuwisse, Aukje K Klungel, Olaf H von Euler, Mia Braunschweig, Frieder Wallén, Håkan Hjemdahl, Paul
Published in
European heart journal. Cardiovascular pharmacotherapy
To analyse 90-day mortality in atrial fibrillation (AF) patients after a stroke or a severe bleed and assess associations with the type of antithrombotic treatment at the event. From the Stockholm Healthcare database, we selected 6017 patients with a known history of AF who were diagnosed with ischaemic stroke, 3006 with intracranial haemorrhage, a...
Senguttuvan, Nagendra Boopathy Sankaran, Ramesh Rajeev, Yashasvi Thaiyal, Devi Mathew, Angel Dharsini, K. Marcelene, Divya Kalsingh, Maria Jusler Sahu, Sujit Kumar Sampath, Aravind
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Published in
The Egyptian Heart Journal
BackgroundDual antiplatelet therapy is the current standard of care after acute coronary syndrome (ACS) and percutaneous coronary intervention (PCI). We intended to study the pattern of use of ticagrelor in patients with acute coronary syndrome undergoing PCI and the effect of switching over to other P2Y12 receptor inhibition on clinical outcomes.R...
Ageron, Francois-Xavier Coats, Timothy J. Darioli, Vincent Roberts, Ian
Published in
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
BackgroundTranexamic acid reduces surgical blood loss and reduces deaths from bleeding in trauma patients. Tranexamic acid must be given urgently, preferably by paramedics at the scene of the injury or in the ambulance. We developed a simple score (Bleeding Audit Triage Trauma score) to predict death from bleeding.MethodsWe conducted an external va...
Černý, Vladimir Maegele, Marc Agostini, Vanessa Fries, Dietmar Leal-Noval, Santiago R. Nardai, Gábor Nardi, Giuseppe Östlund, Anders Schöchl, Herbert
Published in
European Journal of Trauma and Emergency Surgery
Purpose Trauma is a leading cause of mortality, with major bleeding and trauma-induced coagulopathy (TIC) contributing to negative patient outcomes. Treatments for TIC include tranexamic acid (TXA), fresh frozen plasma (FFP), and coagulation factor concentrates (CFCs, e.g. prothrombin complex concentrates [PCCs] and fibrinogen concentrate [FCH]). G...