Selegato, Denise M. Freitas, Thamires R. Pivatto, Marcos Pivatto, Amanda D. Pilon, Alan C. Castro-Gamboa, Ian
Published in
Metabolomics
Introduction In microbial metabolomics, the use of multivariate data analysis (MDVA) has not been comprehensively explored regarding the different techniques available and the information that each gives about the metabolome. To overcome these limitations, here we show the use of Fusarium oxysporum cultured in the presence of exogenous alkaloids as...
Khattab, Amira R Farag, Mohamed A
Published in
Critical reviews in biotechnology
Endophytic fungi are a kind of fungi that colonizes living plant tissues presenting a myriad of microbial adaptations that have been developed in such a hidden environment. Owing to its large diversity and particular habituation, they present a golden mine for research in the field of drug discovery. Endophytic fungal communities possess unique bio...
Song, Dongdong Chen, Lizhao Zhu, Siqi Zhang, Li
Published in
Environmental pollution (Barking, Essex : 1987)
Aquatic organisms such as fish can accumulate high levels of arsenic (As) and transform toxic inorganic As (iAs) to non-toxic arsenobetaine (AsB). Whether the gut microbiota are involved in the process of As accumulation and transformation in fish is unclear. Herein, we subjected tilapia (Oreochromis mossambicus) to antibiotic treatment for 19 d to...
Luo, Jiaer Mobley, Rebecca Woodfine, Sian Drijfhout, Falko Horrocks, Paul Ren, Xiao-Dong Li, Wen-Wu
Published in
Applied microbiology and biotechnology
Artemisinin is a component part of current frontline medicines for the treatment of malaria. The aim of this study is to make analogues of artemisinin using microbial transformation and evaluate their in vitro antimalarial activity. A panel of microorganisms were screened for biotransformation of artemisinin (1). The biotransformation products were...
Satasiya, Gopi Vijaybhai Bhojani, Gopal Kikani, Mansi Amit, Chanchpara Dineshkumar, Ramalingam Kumar, Madhava Anil
Published in
Environmental research
The present investigation reports the biotransformation of an endrocrine disrupting agent; 1,4-dioxane through bacterial metabolism. Initially, potential bacterial isolates capable of surviving with minimum 1,4-dioxane were screened from industrial wastewater. Thereafter, screening was done to isolate a bacteria which can biotransform higher concen...
Liu, Lingyu Hobohm, Leonie Bredendiek, Felix Froschauer, Alexander Zierau, Oliver Parr, Maria Kristina Keiler, Annekathrin M.
Published in
Archives of Toxicology
In anti-doping science, the knowledge of drug metabolism is a prerequisite to identify analytical targets for the detection of misused prohibited substances. As the most obvious way to study xenobiotic metabolism, the administration to human volunteers, faces ethical concerns, there is a need for model systems. In the present study, we investigated...
Sun, Yue Wang, Qi Wu, Xian Li, Fang Song, Mingyue Wang, Minqi Cai, Xiaokun Li, Zhengze Gao, Zili Zheng, Jinkai
...
Published in
Food chemistry
The metabolic fate of dietary compounds is closely related to their biological functions. Pterostilbene (PT) is a methylated stilbene found in many plant foods. Herein, we investigated gastrointestinal biotransformation and tissue distribution of PT in mice fed with 0.05% PT (w/w) for 5 weeks. PT and its major metabolites i.e. PT sulfate (PT-S), pi...
Nobre, Clarisse González, Alondra Losoya, Carolina Teixeira, José A Belmares, Ruth Abrunhosa, Luís
Published in
Food chemistry
Powdered Pleurotusostreatus (PO) was tested for the detoxification of ochratoxin A (OTA) and zearalenone (ZEN) through in vitro gastrointestinal digestion in the absence and presence of ground feed and cornmeal. Ochratoxin α was detected in the chromatograms after OTA elimination, suggesting the presence of an OTA-hydrolytic enzyme in the PO, where...
Smythe, Tristan A Su, Guanyong Bergman, Åke Letcher, Robert J
Published in
Environment international
Over the past few decades, production trends of the flame retardant (FR) industry, and specifically for brominated FRs (BFRs), is for the replacement of banned and regulated compounds with more highly brominated, higher molecular weight compounds including oligomeric and polymeric compounds. Chemical, biological, and environmental stability of BFRs...
Sarwade, Vasudeo Funde, Sharad
Published in
Environmental Analysis, Health and Toxicology
Nitro-aromatics are listed in carcinogenic, teratogenic, and mutagenic compounds list. p-nitro-aniline is one of them used as a precursor of various chemical compounds in many industries like dyes, drugs, paints and several others. These are mostly given out as an effluent in rivers, lakes or open passage of land which exert several hazards to livi...