Interactions among biomacromolecules, predominantly noncovalent, underpin biological processes. However, recent advancements in biospecific chemistry have enabled the creation of specific covalent bonds between biomolecules, both in vitro and in vivo. This Review traces the evolution of biospecific chemistry in proteins, emphasizing the role of gen...
Published in Frontiers in Bioengineering and Biotechnology
Succinic acid (SA), one of the 12 top platform chemicals produced from biomass, is a precursor of various high value-added derivatives. Specially, 1 mol CO2 is assimilated in 1 mol SA biosynthetic route under anaerobic conditions, which helps to achieve carbon reduction goals. In this review, methods for enhanced CO2 fixation in SA production and u...
Lower back pain continues to be a global epidemic, limiting quality of life and ability to work, due in large part to symptomatic disc degeneration. Development of more effective and less invasive biological strategies are needed to treat disc degeneration. In vitro models such as macro- or micro-bioreactors or mechanically active organ-chips hold ...
Chondrocytes within articular cartilage possess the capacity to perceive and react to signals generated by the typical load-bearing actions of daily life, such as walking or running. Articular cartilage is predominantly oriented toward compression-based functionality, and thus the application of such stimuli dominates the field of cartilage regener...
Nitrification in extreme conditions was studied in a gas/liquid bioreactor treating gaseous ammonia (NH3) emissions. As autotrophic bacteria can use simple inorganic compounds to supplement their energy requirements (i.e., NH3 and carbon dioxide CO2 from air), no nutrients or carbon sources were introduced into the water to support biomass growth. ...
Published in Biodegradation
Endocrine-disrupting phthalates (EDPs) are widely used as plasticizers for the manufacture of different plastics and polyvinyl chloride by providing flexibility and mechanical strength. On the other hand, they are categorized under priority pollutants list due to their threat to human health and the environment. This study examined biodegradation o...
Anaerobic digestion is a widely used process for organic waste treatment and biogas production. It is a complex process involving four main biochemical reactions, four microbial groups, and hydrodynamics phenomena. Research focuses on the development of numerical models based on mass transfer and biochemical reaction kinetics, adapted to a specific...
Published in Applied biochemistry and biotechnology
Biofilm cells have a different physiology than planktonic cells, which has been the focus of most research. Biofilms are complex biostructures that form on any surface that comes into contact with water on a regular basis. They are dynamic, structurally complex systems having characteristics of multicellular animals and multiple ecosystems. The thr...
Nanaerobes are a newly described class of microorganisms that use a unique cytochrome bd oxidase to achieve nanaerobic respiration at
Published in Stem cell reviews and reports
In recent years, great breakthroughs have been made in basic research and clinical applications of stem cells in regenerative medicine and other fields, which continue to inspire people to explore the field of stem cells. With nearly unlimited self-renewal ability, stem cells can generate at least one type of highly differentiated daughter cell, wh...
