Wells, Ellen M Kopylev, Leonid Nachman, Rebecca Radke, Elizabeth G Congleton, Johanna Segal, Deborah
Published in
Biological trace element research
Many studies evaluating methylmercury (MeHg) toxicity rely on whole blood total mercury (THg) measurements to estimate MeHg exposure. However, whole blood THg includes other forms of mercury (Hg), such as inorganic Hg, which have different exposure sources and toxicological effects than MeHg. Therefore, estimating the whole blood MeHg/THg ratio is ...
Amaador, Karima Wieske, Luuk Koel-Simmelink, Marleen J A Kamp, A Jongerius, Ilse de Heer, Koen Teunissen, Charlotte E Minnema, Monique C Notermans, Nicolette C Eftimov, Filip
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Published in
Journal of neurology
In anti-myelin-associated glycoprotein IgM paraprotein-related peripheral neuropathy (anti-MAG PN), there is a lack of reliable biomarkers to select patients eligible for therapy and for evaluating treatment effects, both in routine practice and in clinical trials. Neurofilament light chain (NfL) and contactin-1 (CNTN1) can serve as markers of axon...
Raina, Rupesh Sethi, Sidharth K Dragon-Durey, Marie-Agnès Khooblall, Amrit Sharma, Divya Khandelwal, Priyanka Shapiro, Ron Boyer, Olivia Yap, Hui Kim Bagga, Arvind
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Published in
Pediatric nephrology (Berlin, Germany)
Observing biomarkers that affect alternative pathway dysregulation components may be effective in obtaining a new and more rapid diagnostic portrayal of atypical hemolytic uremic syndrome. We have conducted a systematic review on the aHUS biomarkers: C3, C5a, C5b-9, factor B, complement factor B, H, and I, CH50, AH50, D-dimer, as well as anti-CFH a...
Sciaccaluga, C Mandoli, G E Ghionzoli, N Anselmi, F Dini, C Sorini Righini, F Cesareo, F D'Ascenzi, F Focardi, M Valente, S
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Published in
Heart failure reviews
Cardiogenic shock is a clinical syndrome which is defined as the presence of primary cardiac disorder that results in hypotension together with signs of organ hypoperfusion in the state of normovolaemia or hypervolaemia. It represents a complex life-threatening condition, characterized by a high mortality rate, that requires urgent diagnostic asses...
Zhao, Zhong Zhu, Zhipeng Zhang, Xiaobin Tang, Haiming Xing, Jiayi Hu, Xinyao Lu, Jianping Qu, Xingda
Published in
Journal of autism and developmental disorders
Our study investigated the feasibility of using head movement features to identify individuals with autism spectrum disorder (ASD). Children with ASD and typical development (TD) were required to answer ten yes-no questions, and they were encouraged to nod/shake head while doing so. The head rotation range (RR) and the amount of rotation per minute...
Kuipers, Sanne Overmars, L Malin van Es, Bram de Bresser, Jeroen Bron, Esther E Hoefer, Imo E Kappelle, L Jaap Teunissen, Charlotte E Biessels, Geert Jan Haitjema, Saskia
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Published in
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Biological processes underlying cerebral small vessel disease (cSVD) are largely unknown. We hypothesized that identification of clusters of inter-related bood-based biomarkers that are associated with the burden of cSVD provides leads on underlying biological processes. In 494 participants (mean age 67.6 ± 8.7 years; 36% female; 75% cardiovascular...
Kadir, Rais Reskiawan A Alwjwaj, Mansour Bayraktutan, Ulvi
Published in
Cellular and molecular neurobiology
Stroke continues to be the third-leading cause of death and disability worldwide. The limited availability of diagnostic tools approved therapeutics and biomarkers that help monitor disease progression or predict future events remain as the major challenges in the field of stroke medicine. Hence, attempts to discover safe and efficacious therapeuti...
Karmon, Gidon Sragovich, Shlomo Hacohen-Kleiman, Gal Ben-Horin-Hazak, Inbar Kasparek, Petr Schuster, Björn Sedlacek, Radislav Pasmanik-Chor, Metsada Theotokis, Paschalis Touloumi, Olga
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Published in
Biological psychiatry
ADNP is essential for embryonic development. As such, de novo ADNP mutations lead to an intractable autism/intellectual disability syndrome requiring investigation. Mimicking humans, CRISPR (clustered regularly interspaced short palindromic repeats)-Cas9 editing produced mice carrying heterozygous Adnp p.Tyr718∗ (Tyr), a paralog of the most common ...
Soldozy, Sauson Yağmurlu, Kaan Norat, Pedro Elsarrag, Mazin Costello, John Farzad, Faraz Sokolowski, Jennifer D Sharifi, Khadijeh A Elarjani, Turki Burks, Joshua
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Published in
World neurosurgery
The goal of this study was to systematically review the usefulness of serum biomarkers in the setting of ischemic stroke (IS) to predict long-term outcome. A systematic literature review was performed using the PubMed and MEDLINE databases for studies published between 1986 and 2018. All studies assessing long-term functional outcome (defined as ≥3...
Dunga, Sai Kumar Kavadichanda, Chengappa Gupta, Latika Naveen, R Agarwal, Vikas Negi, Vir Singh
Published in
Rheumatology international
To study the demographic, clinical and serologic characteristics of anti-MDA5-positive DM from two geographically and ethnically disparate inception cohorts in India. To identify the clinical and serological parameters at inception that could predict mortality among these individuals. Individuals with anti-MDA5 antibody-positive DM diagnosed betwee...
