Hudeček, Jan Voorwerk, Leonie van Seijen, Maartje Nederlof, Iris de Maaker, Michiel van den Berg, Jose van de Vijver, Koen K. Sikorska, Karolina Adams, Sylvia Demaria, Sandra
...
Published in
npj Breast Cancer
Stromal tumor-infiltrating lymphocytes (sTILs) are a potential predictive biomarker for immunotherapy response in metastatic triple-negative breast cancer (TNBC). To incorporate sTILs into clinical trials and diagnostics, reliable assessment is essential. In this review, we propose a new concept, namely the implementation of a risk-management frame...
Titeca-Beauport, Dimitri Daubin, Delphine Van Vong, Ly Belliard, Guillaume Bruel, Cédric Alaya, Sami Chaoui, Karim Andrieu, Maud Rouquette-Vincenti, Isabelle Godde, Frederic
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Published in
Critical Care
BackgroundThe urine biomarkers tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) have been validated for predicting and stratifying AKI. In this study, we analyzed the utility of these biomarkers for distinguishing between transient and persistent AKI in the early phase of septic shock.Metho...
Wu, Lingling Chen, Ling Zhu, Lingjiao Chen, Xiaoping Li, Qian
Published in
Environmental Sciences Europe
BackgroundSediments function as a secondary and significant source of tributyltin (TBT) and triphenyltin (TPT) in aquatic ecosystems and may pose a potential threat on benthic organisms and human health. The subchronic toxicity of sediment-associated TBT or TPT to snails Bellamya aeruginosa at environmentally relevant concentrations was investigate...
Liu, Dawei Zhu, Yanbin Chen, Wei Li, Junyong Zhao, Kuo Zhang, Junzhe Meng, Hongyu Zhang, Yingze
Published in
Journal of Orthopaedic Surgery and Research
ObjectiveTo determine the relationship between inflammation/immune-based indexes and deep venous thrombosis (DVT) incidence rate following tibial plateau fracturesMethodsRetrospective analysis of a prospectively collected data on patients undergoing surgeries of tibial plateau fractures between October 2014 and December 2018 was performed. Duplex u...
Fassan, Matteo Brignola, Stefano Pennelli, Gianmaria Alberti, Giulia Angerilli, Valentina Bressan, Alessandra Pellino, Antonio Lanza, Cristiano Salmaso, Roberta Lonardi, Sara
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Published in
Virchows Archiv : an international journal of pathology
Immunotherapy has been recently approved for gastric (GC) and gastroesophageal-junction adenocarcinomas (GEC), and PD-L1 immunohistochemical evaluation represents a promising predictive biomarker in this oncological setting. A series of 125 gastroesophageal dysplastic lesions (52 low-grade, 73 high-grade) was investigated for PD-L1 and DNA mismatch...
Takada, Toshihiko Hoogland, Jeroen Yano, Tetsuhiro Fujii, Kotaro Fujiishi, Ryuto Miyashita, Jun Takeshima, Taro Hayashi, Michio Azuma, Teruhisa Moons, Karel G M
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Published in
The American journal of emergency medicine
To evaluate the added value of inflammatory markers to vital signs to predict mortality in patients suspected of severe infection. This study was conducted at an acute care hospital (471-bed capacity). Consecutive adult patients suspected of severe infection who presented to either ambulatory care or the emergency department from April 2015 to Marc...
Ferreiro, Lucía Lado-Baleato, Óscar Toubes, María E Suárez-Antelo, Juan Pose-Reino, Antonio San José, María E Álvarez-Dobaño, José Manuel González-Barcala, Francisco J Ricoy, Jorge Gude, Francisco
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Published in
Archivos de bronconeumologia
Pleural effusion occurs as a response of the pleura to aggressions. The pleura reacts differently according to the type of injury. However, pleural reactions have not yet been characterized. The objective of this study was to identify homogeneous clusters of patients based on the analytical characteristics of their pleural fluid and identify pleura...
Sagel, Scott D Wagner, Brandie D Ziady, Assem Kelley, Tom Clancy, John P Narvaez-Rivas, Monica Pilewski, Joseph Joseloff, Elizabeth Sha, Wei Zelnick, Leila
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Published in
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
Circulating biomarkers reflective of lung disease activity and severity have the potential to improve patient care and accelerate drug development in CF. The objective of this study was to leverage banked specimens to test the hypothesis that blood-based biomarkers discriminate CF children segregated by lung disease severity. Banked serum samples w...
Gooding, Kim M. Lienczewski, Chrysta Papale, Massimo Koivuviita, Niina Maziarz, Marlena Dutius Andersson, Anna-Maria Sharma, Kanishka Pontrelli, Paola Garcia Hernandez, Alberto Bailey, Julie
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Published in
BMC Nephrology
BackgroundDiabetic kidney disease (DKD) remains one of the leading causes of premature death in diabetes. DKD is classified on albuminuria and reduced kidney function (estimated glomerular filtration rate (eGFR)) but these have modest value for predicting future renal status. There is an unmet need for biomarkers that can be used in clinical settin...
Zhang, Jing Shih, David J. H. Lin, Shiaw-Yih
Published in
Biomarker Research
Defect in DNA damage response (DDR) is a common feature of cancer cells, which regulates tumor growth and therapeutic response. Recently, the approval of immune checkpoint blockade (ICB) for tumors with defective mismatch repair has paved the way for investigating the role of other DDR defects in sensitizing cancer to ICB therapy. Despite great pro...
