Chi, Lang-Ming Hsiao, Yung-Chin Chien, Kun-Yi Chen, Szu-Fan Chuang, Yao-Ning Lin, Shih-Yu Wang, Wei-Shun Chang, Ian Yi-Feng Yang, Chi Chu, Lichieh Julie
...
Published in
Journal of proteomics
For oral cancer, numerous saliva- and plasma-derived protein biomarker candidates have been discovered and/or verified; however, it is unclear about the behavior of these candidates as saliva or plasma biomarkers. In this study, we developed two targeted assays, MRM and SISCAPA-MRM, to quantify 30 potential biomarkers in both plasma and saliva samp...
Ma, Zhonghua Shuai, You Gao, Xiangyu Wen, Xianzi Ji, Jiafu
Published in
Molecular Cancer
BackgroundCircular RNAs (circRNAs) are a new class of endogenous non-coding RNAs (ncRNAs) widely expressed in eukaryotic cells. Mounting evidence has highlighted circRNAs as critical regulators of various tumours. More importantly, circRNAs have been revealed to recruit and reprogram key components involved in the tumour microenvironment (TME), and...
Nkuipou-Kenfack, Esther Latosinska, Agnieszka Yang, Wen-Yi Fournier, Marie-Céline Blet, Alice Mujaj, Blerim Thijs, Lutgarde Feliot, Elodie Gayat, Etienne Mischak, Harald
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Published in
Critical Care
RationaleThe urinary proteome reflects molecular drivers of disease.ObjectivesTo construct a urinary proteomic biomarker predicting 1-year post-ICU mortality.MethodsIn 1243 patients, the urinary proteome was measured on ICU admission, using capillary electrophoresis coupled with mass spectrometry along with clinical variables, circulating biomarker...
Thomas, Jithin Pociute, Aiste Kevalas, Rimantas Malinauskas, Mantas Jankauskaite, Lina
Published in
Italian Journal of Pediatrics
Background and objectivesThe goal of this literature review is to compare current studies regarding the accuracy of different serum markers in differentiating viral from bacterial pneumonia in the pediatric population with what is employed in the medical settings at present. Currently there is still a lack of significant research, that would give u...
Zhang, Chengwei Leng, Lei Li, Zhaozheng Zhao, Yao Jiao, Jundong
Published in
BMC Medical Genomics
BackgroundMembranous glomerulonephritis (MGN) is a common kidney disease. Despite many evidences support that many immune and inflammation-related genes could serve as effective biomarkers and treatment targets for MGN patients, the potential associations among MGN-, immune- and inflammation-related genes have not been sufficiently understood.Metho...
de Araujo, Leonardo Silva Pessler, Kevin Sühs, Kurt-Wolfram Novoselova, Natalia Klawonn, Frank Kuhn, Maike Kaever, Volkhard Müller-Vahl, Kirsten Trebst, Corinna Skripuletz, Thomas
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Published in
Journal of Translational Medicine
BackgroundThe timely diagnosis of bacterial meningitis is of utmost importance due to the need to institute antibiotic treatment as early as possible. Moreover, the differentiation from other causes of meningitis/encephalitis is critical because of differences in management such as the need for antiviral or immunosuppressive treatments. Considering...
Klimiec-Moskal, Elzbieta Piechota, Marcin Pera, Joanna Weglarczyk, Kazimierz Slowik, Agnieszka Siedlar, Maciej Dziedzic, Tomasz
Published in
Journal of Neuroinflammation
BackgroundInflammation is associated with poor outcome after stroke. A relationship between ex vivo cytokine synthesis and stroke outcome remains unclear. We explored an association between ex vivo cytokine release, circulating interleukin (IL)-6 as a marker of systemic inflammation, and stroke prognosis. We assessed the utility of ex vivo synthesi...
Lin, Jian-Xian Lin, Jun-Peng Xie, Jian-Wei Wang, Jia-bin Lu, Jun Chen, Qi-Yue Cao, Long-long Lin, Mi Tu, Ruhong Zheng, Chao-Hui
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Published in
BMC Cancer
BackgroundWe sought to investigate the prognostic value of complete blood count (CBC)-based biomarkers for patients with resectable gastric cancer (GC).MethodsPatients with GC who underwent primary surgical resection between December 2008 and December 2013 were included. The estimated area under the curve (AUC) and multivariate Cox regression model...
Wei, Wene Liu, Mengshu Ning, Shufang Wei, Jing Zhong, Jianhong Li, Jilin Cai, Zhengmin Zhang, Litu
Published in
BMC Cancer
BackgroundHepatocellular carcinoma (HCC) is a major health problem worldwide. However, the popular tumor marker, AFP, lacks sensitivity although its specificity is high. Tissue biopsy is an invasive operation and may increase the risk of needle-track metastases. Heat shock protein 90 (HSP90) is a potential biomarker for tumor diagnosis and prognosi...
Pernot, Simon Terme, Magali Radosevic-Robin, Nina Castan, Florence Badoual, Cécile Marcheteau, Elie Penault-Llorca, Fréderique Bouche, Olivier Bennouna, Jaafar Francois, Eric
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Published in
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
The correlation between immune cells and the Lauren classification subtypes and their prognostic impact in advanced gastric cancer (AGC) are unknown. Circulating natural killer (NK) cells, CD4+ and CD8+ T cells, regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs) were quantified in peripheral blood mononuclear cells (PBMCs) from...
