Nariai, Maika Abe, Hiroko Hoshioka, Yumi Makino, Yohsuke Iwase, Hirotaro
Published in
International journal of legal medicine
Acute metabolic disorders of diabetes mellitus (DM), such as diabetic ketoacidosis, hyperosmolar hyperglycemic state, and hypoglycemia, are life-threatening and difficult to diagnose postmortem owing to lack of macroscopic and microscopic findings, especially when the medical history of the patient is not available before autopsy. Although various ...
Thavarajasingam, Santhosh G El-Khatib, Mahmoud Vemulapalli, Kalyan V Iradukunda, Hector A Sinzinkayo Laleye, Joshua Russo, Salvatore Eichhorn, Christian Eide, Per K
Published in
Acta neurochirurgica
Idiopathic normal pressure hydrocephalus (iNPH) is a neurodegenerative disease and dementia subtype involving disturbed cerebrospinal fluid (CSF) homeostasis. Patients with iNPH may improve clinically following CSF diversion through shunt surgery, but it remains a challenge to predict which patients respond to shunting. It has been proposed that CS...
Gargh, Kapil Al-Abadi, Eslam Low, Samantha Harrison, Kathryn Coles, William Davis, Penny Johnson, Karl
Published in
Rheumatology international
The Paediatric Rheumatology International Trials Organisation (PRINTO) criteria for clinically inactive disease (CID) and their proposal for glucocorticoid tapering do not consider MRI findings, despite the growing use of MRI and development of reliable MRI scoring tools. We aim to evaluate how CID correlates with MRI scores and physician decision ...
León, Xavier García, Jacinto Pujol, Albert de Juan, Julia Vásquez, Rosselin Quer, Miquel Camacho, Mercedes
Published in
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Proviral integration site for Moloney murine leukemia virus (PIMs) are proto-oncogenes encoding serine/threonine kinases that phosphorylate a variety of substrates involved in the regulation of cellular processes. Elevated expression of PIM-1 has been associated with poor prognosis in several types of cancer. There are no studies that have analyzed...
Carroll, Ricki S Olney, Robert C Duker, Angela L Coghlan, Ryan F Mackenzie, William G Ditro, Colleen P Brown, Cassondra J O'Connell, David A Horton, William A Johnstone, Brian
...
Published in
Calcified tissue international
Collagen X marker (CXM) is a degradation fragment of collagen type X. It is a real-time biomarker of height velocity with established norms. Plasma C-type natriuretic peptide (CNP) and NTproCNP levels have also been found to correlate with growth velocity in the general population and are elevated in individuals with achondroplasia compared with ag...
Jia, Longfei Zhu, Min Yang, Jianwei Pang, Yana Wang, Qi Li, TingTing Li, Fangyu Wang, Qigeng Li, Yan Wei, Yiping
...
Published in
Biological psychiatry
Exosomal microRNAs (miRNAs) have been demonstrated to be biomarkers of Alzheimer's disease (AD). However, whether exosomal miRNAs can predict AD at the asymptomatic stage remains unclear. This study is a multicenter study with four independent datasets to verify the capacity of exosomal miRNAs to identify preclinical AD. Subjects were recruited fro...
Sasa, Gabriel B K Xuan, Cheng Lyu, Guoliang Ding, Xianfeng Meiyu, Fang
Published in
Molecular biotechnology
Due to their biological activities in regulating dosage compensation, epigenetics, and cell differentiation, long non-coding RNAs (lncRNA) have been recognized as important regulators of the beginning and development of human malignancies. LncRNA dysregulation has a significant impact on a range of cellular functions, including proliferation, migra...
Tan, Qiaoyun Dai, Liyuan Wang, Yanrong Liu, Shuxia Liang, Te Luo, Rongrong Wang, Shasha Lou, Ning Chen, Haizhu Zhou, Yu
...
Published in
Cancer immunology, immunotherapy : CII
Antibodies targeting programmed cell death-1(PD1) and its ligand (PDL1) have revolutionized cancer therapy. However, little is known about the preexisted anti-PD1/PDL1 autoantibodies (AAbs) distribution in multiple cancer types, nor is their potential biomarker role for anti-PD1 therapy. Plasma anti-PD1/PDL1 AAb IgG and subclasses (IgG1-4) were det...
Wang, Wenhui Tian, Bei Ning, Zhongping Li, Xinming
Published in
Molecular biotechnology
Atrial fibrillation (AF) is one of the most common arrhythmias in adults, with high morbidity and increased mortality risk. In recent years, the clinical diagnosis, treatment, and mechanistic research of AF have increased exponentially, and regulation based on the potential molecular mechanism of AF is a research hotspot. Long noncoding RNAs (LncRN...
Matsumoto, Yuki Orihara, Yoshiyuki Asakura, Masanori Min, Kyung-Duk Okuhara, Yoshitaka Azuma, Kohei Nishimura, Koichi Sunayama, Isamu Kashiwase, Kazunori Naito, Yoshiro
...
Published in
Heart and vessels
Detecting high-risk patients for early rehospitalization is crucial in heart failure patient care. An association of albuminuria with cardiovascular events is well known. However, its predictive impact on rehospitalization for acute decompensated heart failure (ADHF) remains unknown. In this study, 190 consecutive patients admitted due to ADHF betw...
