Debruyne, Angela C Okkelman, Irina A Dmitriev, Ruslan I
Published in
Seminars in cell & developmental biology
Cell death is a phenomenon, frequently perceived as an absolute event for cell, tissue and the organ. However, the rising popularity and complexity of such 3D multicellular 'tissue building blocks' as heterocellular spheroids, organoids, and 'assembloids' prompts to revise the definition and quantification of cell viability and death. It raises sev...
Meumann, Nadja Cabanes-Creus, Marti Ertelt, Moritz Navarro, Renina Gale Lucifora, Julie Yuan, Qinggong Nien-Huber, Karin Abdelrahman, Ahmed Vu, Xuan-Khang Zhang, Liang
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Published in
Hepatology (Baltimore, Md.)
Current liver-directed gene therapies look for adeno-associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural serotypes by peptide insertion...
De Ryck, Joren Van Damme, Petra Goormachtig, Sofie
Published in
Frontiers in Microbiology
The type III secretion system (T3SS) is a well-studied pathogenicity determinant of many bacteria through which effectors (T3Es) are translocated into the host cell, where they exercise a wide range of functions to deceive the host cell’s immunity and to establish a niche. Here we look at the different approaches that are used to functionally chara...
Andrade Galan, Ana Gabriela Doll, Jasmin Saile, Svenja Corina Wünsch, Marieluise Roepenack-Lahaye, Edda von Pauwels, Laurens Goossens, Alain Bresson, Justine Zentgraf, Ulrike
The HD-ZIP III transcription factor REVOLUTA (REV) is involved in early leaf development, as well as in leaf senescence. REV directly binds to the promoters of senescence-associated genes, including the central regulator WRKY53. As this direct regulation appears to be restricted to senescence, we aimed to characterize protein-interaction partners o...
Rehnberg, Emil Quaghebeur, Katrijn Baselet, Bjorn Rajan, Nicholas Shazly, Tarek Moroni, Lorenzo Baatout, Sarah Tabury, Kevin
Published in
Frontiers in Sensors
Human presence in space has uncovered several health concerns related to the space environment that need to be addressed for future space missions. The hostile space environment includes radiation and microgravity that cause various pathophysiological effects. Among them are conditions related to the cardiovascular system. The cardiovascular system...
Chen, Hengchi Fang, Yuhan Zwaenepoel, Arthur Huang, Sanwen Van de Peer, Yves Li, Zhen
Published in
The New phytologist
Ferns, and particularly homosporous ferns, have long been assumed to have experienced recurrent whole-genome duplication (WGD) events because of their substantially large genome sizes, surprisingly high chromosome numbers, and high degrees of polyploidy among many extant members. As the number of sequenced fern genomes is limited, recent studies ha...
Andrić, Sofija Rigolet, Augustin Argüelles Arias, Anthony Steels, Sébastien Hoff, Grégory Balleux, Guillaume Ongena, Loïc Höfte, Monica Meyer, Thibault Ongena, Marc
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Published in
The ISME journal
Bacillus velezensis is considered as model species for plant-associated bacilli providing benefits to its host such as protection against phytopathogens. This is mainly due to the potential to secrete a wide range of secondary metabolites with specific and complementary bioactivities. This metabolite arsenal has been quite well defined genetically ...
Hirt, Heribert Al-Babili, Salim Almeida-Trapp, Marilia Antoine, Martin Aranda, Manuel Bartels, Dorothea Bennett, Malcolm Blilou, Ikram Boer, Damian Boulouis, Alix
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Greenhouse gas (GHG) emissions have created a global climate crisis which requires immediate interventions to mitigate the negative effects on all aspects of life on this planet. As current agriculture and land use contributes up to 25% of total GHG emissions, plant scientists take center stage in finding possible solutions for a transition to sust...
Merlevede, Valentien Ninclaus, Virginie Roels, Dimitri Huys, Liesbeth Callewaert, Bert Kreps, Elke O
Published in
Ophthalmic genetics
Ligneous conjunctivitis is a very rare form of pseudomembranous conjunctivitis with few published cases in literature. We aim to describe the ocular findings and treatment in an infant with ligneous conjunctivitis resembling preseptal cellulitis on presentation. Case report of a 3-month-old girl who was referred to a tertiary centre for ophthalmic ...
Singh, Harshita Singh, Zeenu Zhu, Tingting Xu, Xiangyu Waghmode, Bhairavnath Garg, Tushar Yadav, Shivani Sircar, Debabrata De Smet, Ive Yadav, Shri Ram
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Published in
Plant & cell physiology
The rice root system is primarily composed of shoot-borne adventitious/crown roots (ARs/CRs) that develop from the coleoptile base, and therefore, it is an excellent model system for studying shoot-to-root trans-differentiation process. We reveal global changes in protein and metabolite abundance and protein phosphorylation in response to an auxin ...