Published in Human Heredity
Objectives: Identifying drivers of complex traits from the noisy signals of genetic variation obtained from high-throughput genome sequencing technologies is a central challenge faced by human geneticists today. We hypothesize that the variants involved in complex diseases are likely to exhibit non-neutral evolutionary signatures. Uncovering the ev...
Published in Bulletin of the National Research Centre
BackgroundMulberry silkworm, Bombyx mori L. is one of the most economically important insect because its production of silk which interfere with many important industries. Diseases of the silkworm, B. mori such as viral, bacterial, fungal and protozoan pathogens seriously affect their cocoon production. Bacterial and fungal pathogens independently ...
Published in Linguistic Typology
The Database of Cross-Linguistic Colexifications (CLICS), has established a computer-assisted framework for the interactive representation of cross-linguistic colexification patterns. In its current form, it has proven to be a useful tool for various kinds of investigation into cross-linguistic semantic associations, ranging from studies on semanti...
Does humus exist or is it just a view of the mind as some authors claimed it? I suggest, based on the observation of the activity of soil organisms, that humus should be considered as the 'dark side' of life and not as an intractable chemical component of soil organic matter. Most properties humus confers to the soil ecosystem are linked to high su...
Published in Nietzsche-Studien
The books discussed in this article examine Nietzsche’s philosophy of life in different ways. Nietzsche’s theory of art as well as his Dionysian philosophy play a special role, which emphasizes the possible continuity of these terms in Nietzsche’s works. An additional focus of attention are Nietzsche’s philosophy of the body as well as his relation...
Published in Asploro Journal of Biomedical and Clinical Case Reports
RNase H1 generally processes the RNA- DNA hybrids through non specific interaction between HBD and the ds RNA/DNA hybrid. There are no direct protein- protein interactions between the hybrid and HBD of RNase H1. The DNA binding region is highly conserved compared to RNA binding region and the Kd for RNA/DNA hybrid is less compared to ds RNA than to...
Published in Psychotherapy and Psychosomatics
Construction of a patient narrative (case history) is a core strategy in the care of patients. Recent advances in biomarker identification and digital sensors to monitor physiological and behavioral features have made constructing a case history more complex. Notably, however, although a biological profile is increasingly a part of the patient’s pr...
Organisms modulate their response to changing environmental conditions through changes in gene expression, and extensive variations in gene expression are prevalent among individuals even within a population. This widespread plasticity and variability of gene expression is thought to play roles in adaptation and drive novel phenotypes in species. U...
Published in International Journal of STEM Education
BackgroundIncreasingly, high dropout rates in science courses at colleges and universities have led to discussions of causes and potential support measures of students. Students’ prior knowledge is repeatedly mentioned as the best predictor of academic achievement. Theory describes four hierarchically ordered types of prior knowledge, from declarat...
Mechanical forces are well known for modulating heart valve developmental programs. Yet, it is still unclear how genetic programs and mechanosensation interact during heart valve development. Here, we assessed the mechanosensitive pathways involved during zebrafish outflow tract (OFT) valve development in vivo. Our results show that the hippo effec...
