Published in Revue de pneumologie clinique
Lung cancer is the leading cause of cancer deaths in France, with about 30,000 deaths per year. The overwhelming majority (90 %) are tobacco-related. The prognosis is dark but great therapeutic advances have been made with the development of targeted therapies first and then immunotherapy afterwards. These medications are conditioned to the express...
Malgré une amélioration de la prise en charge thérapeutique au cours des dernières années, les leucémies aiguës myéloïdes (LAM) pédiatriques sont des hémopathies graves, avec des taux de rechute pouvant atteindre 30% et des taux de survie inférieurs à 75%. Une meilleure description des anomalies moléculaires chez les enfants atteints de LAM est néc...
Introduction : le rhabdomyosarcome (RMS) du nourrisson, 4-10% des RMS chez l’enfant, est une entité bien spécifique. Récemment, des réarrangements moléculaires impliquant VGLL2 ont été décrits dans des formes de RMS à cellules fusiformes (RMSsc) du nourrisson.Afin de mieux comprendre l’hétérogénéité des RMS du nourrisson, nous avons réalisé une étu...
Published in Neuro-Chirurgie
Medulloblastomas, embryonal neuroepithelial tumors developed in the cerebellum or brain stem, are mainly observed in childhood. The treatment of WHO-Grade IV tumors depends on stratifications that are usually based on postoperative data, histopathological subtype, tumor extension and presence of MYC or NMYC amplifications. Recently, molecular biolo...
Published in Medecine et maladies infectieuses
Genome editing, which is an unprecedented technological breakthrough, has provided a valuable means of creating targeted mutations in plant genomes. In this study, we developed a genomic web tool to identify all gRNA target sequences in the coffee genome, along with potential off-targets. In all, 8,145,748 CRISPR guides were identified in the draft...
We report on the enhancement of magnetic properties of multiwalled carbon nanotubes (MWNTs) functionalized with a gadolinium based supramolecular complex. By employing a newly developed synthesis technique we find that the functionalization method of the nanocomposite enhances the strength of magnetic interaction leading to a large effective moment...
Xanthomonas vasicola pv. musacearum (Xvm) is a bacterial pathogen responsible for the economically important Xanthomonas wilt disease on banana and enset crops in Sub-Saharan Africa. Given that the symptoms are similar to those of other diseases, molecular diagnosis is essential to unambiguously identify this pathogen and distinguish it from closel...
Com o avanço das técnicas de Biologia molecular, surge a necessidade de se aprimorar protocolos de extração de DNA para que sejam mais rápidos e baratos, possibilitando a inclusão de novas metodologias que tendem a beneficiar seus usuários. Nos protocolos de rotina, o uso do nitrogênio líquido é indispensável para o rompimento da parede celular e r...
Pour l’amélioration de la lutte contre la tuberculose à Madagascar, nous avons décidé de mener des études sur l’analyse de la diversité et la distribution des génotypes de BK y circulant au cours du temps et dans l’espace afin de connaitre le mode de transmission de la TB et les sources potentielles de la TB malgache. Plus spécifiquement il s’agit ...
