Kim, Minjun Ji, Sooyeon Kim, Jiye Min, Kyeongseon Jeong, Hwihun Youn, Jonghyo Kim, Taechang Jang, Jinhee Bilgic, Berkin Shin, Hyeong‐Geol
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Magnetic susceptibility source separation (χ-separation), an advanced quantitative susceptibility mapping (QSM) method, enables the separate estimation of paramagnetic and diamagnetic susceptibility source distributions in the brain. Similar to QSM, it requires solving the ill-conditioned problem of dipole inversion, suffering from so-called streak...
Dveirin, Haley Acuna, Victoria Tran, Mai-Lan Antici, Elizabeth E Kuhlman, Kate Ryan
BackgroundAcute psychosocial stress activates the hypothalamic-pituitary-adrenal (HPA) axis and triggers the release of cortisol, a commonly used biomarker of stress reactivity. Yet only 25 % of studies have reported a correlation between cortisol and affective responses to stress. This study aimed to examine whether cortisol reactivity following a...
Ball, Lewis V Mak, Matthew HC Ryskin, Rachel Curtis, Adam J Rodd, Jennifer M Gaskell, M Gareth
Spitzer, Nicholas C Strowbridge, Ben W
Ryskin, Rachel Gibson, Edward Kiran, Swathi
Individuals with "agrammatic" receptive aphasia have long been known to rely on semantic plausibility rather than syntactic cues when interpreting sentences. In contrast to early interpretations of this pattern as indicative of a deficit in syntactic knowledge, a recent proposal views agrammatic comprehension as a case of "noisy-channel" language p...
Carrera, Sofia C Godoy, Irene Gault, Colleen M Mensing, Ashley Damm, Juliane Perry, Susan E Beehner, Jacinta C
We know more about the costs of chronic stress than the benefits of the acute stress response-an adaptive response that buffers organisms from life-threatening challenges. As yet, no primate study has empirically identified how the stress response adaptively affects evolutionary fitness. Here, we take advantage of a natural experiment-an El Niño dr...
Lynne Nielson, Shai Mayberry, Rachel I
Research shows that insufficient language access in early childhood significantly affects language processing. While the majority of this work focuses on syntax, phonology also appears to be affected, though it is unclear exactly how. Here we investigated phonological production across age of acquisition of American Sign Language (ASL). Participant...
Koch, Elise Shadrin, Alexey A Parker, Nadine Lock, Siobhan K Smith, Robert L Frei, Oleksandr Dale, Anders M Djurovic, Srdjan Molden, Espen O´Connell, Kevin S
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While clozapine is the most effective antipsychotic drug, its use is limited due to hematological adverse effects involving the reduction of granulocyte counts with potential life-threatening agranulocytosis. It is not yet possible to predict or prevent the risk of agranulocytosis, and the mechanisms are unknown but likely related to clozapine meta...
Xia, Frances Fascianelli, Valeria Vishwakarma, Nina Ghinger, Frances Grace Kwon, Andrew Gergues, Mark M Lalani, Lahin K Fusi, Stefano Kheirbek, Mazen A
Anhedonia, the diminished drive to seek, value, and learn about rewards, is a core feature of major depressive disorder1-3. The neural underpinnings of anhedonia and how this emotional state drives behaviour remain unclear. Here we investigated the neural code of anhedonia by taking advantage of the fact that when mice are exposed to traumatic soci...
Appleton, Johanna Finn, Quentin Zanotti-Fregonara, Paolo Yu, Meixiang Faridar, Alireza Nakawah, Mohammad O Zarate, Carlos Carrillo, Maria Dickerson, Bradford C Rabinovici, Gil
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Brain inflammation, with an increased density of microglia and macrophages, is an important component of Alzheimer's disease and a potential therapeutic target. However, it is incompletely characterized, particularly in patients whose disease begins before the age of 65 years and, thus, have few co-pathologies. Inflammation has been usefully imaged...