Liu, Jianyong Chen, Ningjie
Published in
Journal of Orthopaedic Surgery and Research
BackgroundRheumatoid arthritis (RA) is an autoimmune rheumatic disease that carries a substantial burden for both patients and society. Early diagnosis of RA is essential to prevent disease progression and select an optimal therapeutic strategy. However, RA diagnosis is challenging, partly due to a lack of reliable biomarkers. Here, we aimed to exp...
Yang, Kaiying Zhang, Xuepeng Chen, Linwen Chen, Siyuan Ji, Yi
Published in
Cell Division
BackgroundInfantile hemangioma (IH) is the most common benign tumor in children. Long noncoding RNAs (lncRNAs) play a critical role in tumorigenesis. However, the expression levels and biological functions of lncRNAs in IH have not been well-studied. This study aimed to analyze the expression profile of lncRNAs and mRNAs in proliferating and involu...
Tan, Siyou Chen, Wenyan Xiang, Hongxian Kong, Gaoyin Zou, Lianhong Wei, Lai
Published in
Genes & Genomics
Background Since the outbreak of coronavirus disease 2019 (COVID-19) in China, numerous research institutions have invested in the development of anti-COVID-19 vaccines and screening for efficacious drugs to manage the virus. Objective To explore the potential targets and therapeutic drugs for the prevention and treatment of COVID-19 through data m...
Kim, Jihyun You, Sooseong
Published in
BMC Pharmacology and Toxicology
PurposeMost patients with cancer undergo multiple administrations of anticancer drugs during treatment, resulting in chronic impairment of their reproductive health. As improved treatment options increase cancer survival, it has become increasingly important to address fertility issues in cancer survivors. In this study, we examined the pathophysio...
Hozhabri, Hossein Lashkari, Ali Razavi, Seyed-Morteza Mohammadian, Ali
Published in
Medical Oncology
Colorectal cancer (CRC) is one of the most common malignant tumor and prevalent cause of cancer-related death worldwide. In this study, we analyzed the gene expression profiles of patients with CRC with the aim of better understanding the molecular mechanism and key genes in CRC. Four gene expression profiles including, GSE9348, GSE41328, GSE41657,...
Bi, Siwei Liu, Ruiqi He, Linfeng Li, Jingyi Gu, Jun
Published in
BMC Cardiovascular Disorders
BackgroundAneurysm is a severe and fatal disease. This study aims to comprehensively identify the highly conservative co-expression modules and hub genes in the abdominal aortic aneurysm (AAA), thoracic aortic aneurysm (TAA) and intracranial aneurysm (ICA) and facilitate the discovery of pathogenesis for aneurysm.MethodsGSE57691, GSE122897, and GSE...
Wang, Tianyi Zhang, Bingxin Li, Danhui Qi, Xiaoli Zhang, Chijin
Published in
Bioscience reports
The initiation of atopic dermatitis (AD) typically happens very early in life, but most of our understanding of AD is derived from studies on AD patients in adult. The aim of this study was to identify gene signature speficic to pediatric AD comapred to adult AD. The gene expression profiles of four datasets (GSE32924, GSE36842, GSE58558, and GSE10...
Liu, Jinhui Jiang, Pinping Chen, Xucheng Shen, Yujie Cui, Guoliang Ma, Ziyan Zhao, Shaojie Zhang, Yan
Published in
BMC Cancer
BackgroundEndometrial cancer (EC) is one of the most common gynecological malignancies worldwide. However, the molecular mechanisms and the prognostic prediction for EC patients remain unclear.MethodsIn the current study, we performed an in-depth analysis of over 500 patients which were obtained from the Cancer Genome Atlas (TCGA) database. The bio...
Cheng, Qi Chen, Xin Wu, Huaxiang Du, Yan
Published in
Journal of Translational Medicine
BackgroundRheumatoid arthritis (RA) is the most common chronic autoimmune connective tissue disease. However, early RA is difficult to diagnose due to the lack of effective biomarkers. This study aimed to identify new biomarkers and mechanisms for RA disease progression at the transcriptome level through a combination of microarray and bioinformati...
Ge, Yanzhi Zhou, Li Chen, Zuxiang Mao, Yingying Li, Ting Tong, Peijian Shan, Letian
Published in
Hereditas
BackgroundThe disability rate associated with rheumatoid arthritis (RA) ranks high among inflammatory joint diseases. However, the cause and potential molecular events are as yet not clear. Here, we aimed to identify differentially expressed genes (DEGs), pathways and immune infiltration involved in RA utilizing integrated bioinformatics analysis a...
