Maria Vianney, Yoanes Kandinata, Priscilla Weisz, Klaus Goretti Marianti Purwanto, Maria
Published in
E3S Web of Conferences
White spot syndrome virus (WSSV) is considered one of the most infectious and lethal viruses that affect shrimp. Bioinformatic studies revealed several G-quadruplex forming sequences at the open reading frame region. Moreover, the sequences are widely conserved through all deposited WSSV sequences. Introductory structural studies on two sequences, ...
Durmaz, Arda Gurnari, Carmelo Hershberger, Courtney E Pagliuca, Simona Daniels, Noah Awada, Hassan Awada, Hussein Adema, Vera Mori, Minako Ponvilawan, Ben
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Published in
iScience
RNA splicing dysfunctions are more widespread than what is believed by only estimating the effects resulting by splicing factor mutations (SFMT) in myeloid neoplasia (MN). The genetic complexity of MN is amenable to machine learning (ML) strategies. We applied an integrative ML approach to identify co-varying features by combining genomic lesions (...
Chen, Yi-Hui Yang, Shao-Hua Liu, Li-Xin Hu, Sheng Wang, Xue-Jun Liao, Zhou-Jun Huan, Yun-Feng He, Kai Zhang, Xiao-Wen
Published in
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
The FGF/FGFR signaling axis deregulation of the fibroblast growth factor receptor (FGFR) family is closely related to tumorigenesis, tumor progression and drug resistance to anticancer therapy. And fibroblast growth factor receptor 3 (FGFR3) is one member of this family. In this study, we aimed to investigate the effect of siRNA-induced knockdown o...
Espinoza, Diego A Le Coz, Carole Cruz Cabrera, Emylette Romberg, Neil Bar-Or, Amit Li, Rui
Published in
JCI insight
B cells within secondary lymphoid tissues (SLTs) encompass a diversity of activation states and multiple maturation processes that reflect antigen recognition and transition through the germinal center (GC) reaction, in which mature B cells differentiate into memory and antibody-secreting cells (ASCs). Here, utilizing single-cell RNA-seq, we identi...
Zou, Zhi-Li Ye, Yu Zhou, Bo Zhang, Yuan
Published in
World journal of psychiatry
Major depressive disorder (MDD) is a common and serious mental illness. Many novel genes in MDD have been characterized by high-throughput methods such as microarrays or sequencing. Recently, noncoding RNAs (ncRNAs) were suggested to be involved in the complicated environmental-genetic regulatory network of MDD occurrence; however, the interplay am...
Biget, Marine Wang, Tingting Mony, Cendrine Xu, Qicheng Lecoq, Lucie Chable, Véronique Theis, Kevin R. Ling, Ning Vandenkoornhuyse, Philippe
The hologenome concept considers the entity formed by a host and its microbiota, the holobiont, as new level of hierarchical organization subject to neutral and selective forces. We used grafted plants to formally evaluate the hologenome concept. We analyzed the root-endosphere microbiota of two independent watermelon and grapevine plant systems, i...
Mei, Jie Fu, Ziyi Cai, Yun Song, Chenghu Zhou, Jiaofeng Zhu, Yichao Mao, Wenjun Xu, Junying Yin, Yongmei
Published in
iScience
Immune checkpoint inhibitors (ICIs) have transformed the management of advanced cancers. However, many patients could not benefit from ICIs therapy, and thus several biomarkers for therapeutic prediction have been uncovered. In this research, more than ten public and in-house cohorts were used to explore the predictive value and immunological corre...
Hosseini-Gerami, Layla Ficulle, Elena Humphryes-Kirilov, Neil Airey, David C Scherschel, James Kananathan, Sarubini Eastwood, Brian J Bose, Suchira Collier, David A Laing, Emma
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BACKGROUND: A key histopathological hallmark of Alzheimer's disease (AD) is the presence of neurofibrillary tangles of aggregated microtubule-associated protein tau in neurons. Anle138b is a small molecule which has previously shown efficacy in mice in reducing tau aggregates and rescuing AD disease phenotypes. METHODS: In this work, we employed bi...
Zhan, Xiaopeng Jiang, Li Wang, Lufeng Liu, Jiwen Kang, Sheng Liu, Haibo Lin, Li
Published in
Gene
Since the discovery of the Proprotein Convertase Subtilisin/Kexin Type 9(PCSK9) gene has been involved in regulating low-density lipoprotein metabolism and cardiovascular disease (CVD), many therapeutic strategies directly targeting PCSK9 have been introduced. PCSK9 gain of function (GoF) mutations are associated with autosomal dominant hypercholes...
Gao, Han Di, Jiawei Yin, Mingyu He, Tianwei Wu, Depeng Chen, Zihao Li, Shangfu He, Lei Rong, Limin
Published in
Gene
Osteoarthritis (OA) is the most common joint disease. Previous studies were focused on general functions of chondrocyte population in OA without elucidating the existence of chondrocyte subpopulations. To investigate the heterogeneity of chondrocyte, here we conducted detailed analysis on the single-cell sequencing data of cartilage cells from OA p...