Zhou, Shaojiong Liu, Shuo Liu, Xiaoqiang Zhuang, Weiduan
Published in
Journal of molecular neuroscience : MN
Atherosclerotic plaque instability is a major cause of ischemic stroke. Researchers must develop novel strategies for the detection and treatment of unstable atherosclerotic plaque (UAP)-related stroke. We aimed to identify potential biomarkers and therapeutic targets of UAP-related stroke. Differentially expressed genes (DEGs) of UAP, ischemic str...
Sanfilippo, Cristina Musumeci, Giuseppe Kazakova, Maria Mazzone, Venera Castrogiovanni, Paola Imbesi, Rosa Di Rosa, Michelino
Published in
Journal of molecular neuroscience : MN
Brain regions such as the cerebellum (CB) have been neglected for a long time in the study of Alzheimer's disease (AD) pathogenesis. In reference to a new emerging hypothesis according to which there is an altered cerebellar synaptic processing in AD, we verified the possible role played by new biomarkers in the CB of AD patients compared with not-...
Singh, Naveen K Ray, Partha Carlin, Aaron F Magallanes, Celestine Morgan, Sydney C Laurent, Louise C Aronoff-Spencer, Eliah S Hall, Drew A
Significant barriers to the diagnosis of latent and acute SARS-CoV-2 infection continue to hamper population-based screening efforts required to contain the COVID-19 pandemic in the absence of widely available antiviral therapeutics or vaccines. We report an aptamer-based SARS-CoV-2 salivary antigen assay employing only low-cost reagents ($3.20/tes...
Li, Yinchao Chen, Shuda Wang, Chengzhe Wang, Peiling Li, Xi Zhou, Liemin
Published in
Acta Epileptologica
BackgroundThis study was designed to characterize human PRRT2 gene and protein, in order to provide theoretical reference for research on regulation of PRRT2 expression and its involvement in the pathogenesis of paroxysmal kinesigenic dyskinesia and other related diseases.MethodBiological softwares Protparam, Protscale, MHMM, SignalP 5.0, NetPhos 3...
Hermawan, Adam Putri, Herwandhani Utomo, Rohmad Yudi
Published in
Network Modeling Analysis in Health Informatics and Bioinformatics
The efficacy of fulvestrant therapy for estrogen receptor positive (ER+) or luminal breast cancer therapy may decrease on account of chemoresistance, which contributes to tumor relapse and metastasis. Cinnamaldehyde has previously been shown to trigger apoptosis in MCF-7 cells, which are ER+ breast cancer cells. This study aimed to identify the tar...
Zhao, Cui Liu, Jian Zhou, Haomiao Qian, Xin Sun, Hui Chen, Xuewen Zheng, Miaosen Bian, Tingting Liu, Lei Liu, Yifei
...
Published in
Cancer Cell International
BackgroundLung adenocarcinoma (LUAD) is the leading cause of cancer-related death. This study aimed to develop and validate reliable prognostic biomarkers and signature.MethodsDifferentially expressed genes were identified based on three Gene Expression Omnibus (GEO) datasets. Based on 1052 samples’ data from our cohort, GEO and The Cancer Genome A...
Zheng, An Lamkin, Michael Qiu, Yutong Ren, Kevin Goren, Alon Gymrek, Melissa
Published in
BMC Bioinformatics
BackgroundA major challenge in evaluating quantitative ChIP-seq analyses, such as peak calling and differential binding, is a lack of reliable ground truth data. Accurate simulation of ChIP-seq data can mitigate this challenge, but existing frameworks are either too cumbersome to apply genome-wide or unable to model a number of important experiment...
Muneeb, Muhammad Henschel, Andreas
Published in
BMC Bioinformatics
BackgroundGenotype–phenotype predictions are of great importance in genetics. These predictions can help to find genetic mutations causing variations in human beings. There are many approaches for finding the association which can be broadly categorized into two classes, statistical techniques, and machine learning. Statistical techniques are good ...
Lan, Aihua Ren, Chunxia Wang, Xiaoling Tong, Guoqing Yang, Gong
Published in
BMC Cancer
BackgroundGlia maturation factor-γ (GMFG) is reported to inhibit the actin nucleation through binding to the actin-related protein-2/3 complex (Arp2/3). Considering the main function of GMFG in actin remodeling, which is vital for immune response, angiogenesis, cell division and motility, GMFG is supposed to have important roles in tumor developmen...
Arora, Uma P. Charlebois, Caleigh Lawal, Raman Akinyanju Dumont, Beth L.
Published in
BMC Genomics
BackgroundMammalian centromeres are satellite-rich chromatin domains that execute conserved roles in kinetochore assembly and chromosome segregation. Centromere satellites evolve rapidly between species, but little is known about population-level diversity across these loci.ResultsWe developed a k-mer based method to quantify centromere copy number...
