Wang, Jun Wang, Chuyan Yang, Liuqing Li, Kexin
Published in
Medical Oncology
Hepatocellular carcinoma (HCC) is a global health problem with complex etiology and pathogenesis. Microarray data are increasingly being used as a novel and effective method for cancer pathogenesis analysis. An integrative analysis of genes and miRNA for HCC was conducted to unravel the potential prognosis of HCC. Two gene microarray datasets (GSE8...
Lu, Kaining Wei, Shan Wang, Zhengyi Wu, Kerong Jiang, Junhui Yan, Zejun Cheng, Yue
Published in
BMC Urology
Background Hunner’s interstitial cystitis (HIC) is a complex disorder characterized by pelvic pain, disrupted urine storage, and Hunner lesions seen on cystoscopy. There are few effective diagnostic biomarkers. In the present study, we used the novel machine learning tool CIBERSORT to measure immune cell subset infiltration and potential novel diag...
Liu, Zhao Liu, Jiaxin Liu, Ruimiao Xue, Man Zhang, Weifan Zhao, Xinhui Zhu, Jiang Xia, Peng
Published in
BMC Cancer
BackgroundAn important mechanism that promoter methylation-mediated gene silencing for gene inactivation is identified in human tumorigenesis. Methylated genes have been found in breast cancer (BC) and beneficial biomarkers for early diagnosis. Prognostic assessment of breast cancer remain little known. Zinc finger protein 132 (ZNF132) is downregul...
Benvenuto, Domenico Benedetti, Francesca Demir, Ayse Banu Ciccozzi, Massimo Zella, Davide
Published in
Chemotherapy
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped virus initially detected in Wuhan in December 2019, responsible for coronavirus disease 2019 (COVID-19), a respiratory syndrome currently affecting >220 countries around the world, with >80 million cases registered and >1.8 million deaths. Objective: As several...
Yang, Yuanyuan Hong, Senyuan Li, Cong Zhang, Jiaqiao Hu, Henglong Chen, Xiaolong Jiang, Kehua Sun, Fa Wang, Qing Wang, Shaogang
...
Published in
PeerJ
Proteins are the most abundant component of kidney stone matrices and their presence may reflect the process of the stone's formation. Many studies have explored the proteomics of urinary stones and crystals. We sought to comprehensively identify the proteins found in kidney stones and to identify new, reliable biomolecules for use in nephrolithias...
Jia, Yutao Liu, Yang Han, Zhihua Tian, Rong
Published in
PeerJ
Osteosarcoma (OS) is the most primary malignant bone cancer in children and adolescents with a high mortality rate. This work aims to screen novel potential gene signatures associated with OS by integrated microarray analysis of the Gene Expression Omnibus (GEO) database. The OS microarray datasets were searched and downloaded from GEO database to ...
Cui, Xiao-Han Hu, Shu-Yi Zhu, Chun-Fu Qin, Xi-Hu
Published in
BMC Cancer
BackgroundDespite advances in early diagnosis and treatment, cancer remains the leading cause of mortality worldwide. The insulin-like growth factor 2 mRNA binding protein (IGF2BP) family has been reported to be involved in a variety of human malignant tumours. However, little is known about their expression and prognostic value in human pancreatic...
Arnaiz, Olivier
Les nouvelles technologies de séquençage (NGS) ont révolutionné nos approches de la génomique.De nombreux génomes d'organismes ont été séquencés et assemblés.Le décryptage de l'information qu'ils contiennent (annotation) est plus que jamais une étape cruciale.Dans ce manuscrit, je vais me focaliser sur l’impact qu'ont eu les NGS sur l'annotation de...
Villemin, Jean-Philippe
L’épissage alternatif est l’un des mécanismes majeurs conduisant à la diversité du protéome. Il est devenu très clair que ce mécanisme joue un rôle dans de nombreuses maladies génétiques, y compris le cancer. Au cours de l’oncogenèse, le contenu cellulaire en isoformes d’ARN est fortement altéré et ce phénomène semble être spécifique au contexte.Co...
Syahbanu, Fathma Giriwono, Puspo Edi Tjandrawinata, Raymond R Suhartono, Maggy T
Published in
Molecular biology reports
The screening of proteolytic and fibrinolytic bacteria from moromi (an Indonesian soybean-based fermented food) yielded a number of isolates. Based on morphological and biochemical analyses and sequencing of the 16S rRNA gene, the isolate that exhibited the highest proteolytic and fibrinolytic activity was identified as Bacillus subtilis K2. The st...
