Published in Journal of Translational Medicine
BackgroundGlioblastoma multiforme (GBM) is the most malignant tumor in human brain. Diagnosis and treatment of GBM may lead to psychological disorders such as depressive and anxiety disorders. There was no research focusing on the correlation between depressive/anxiety disorder and the outcome of GBM. Thus, the aim of this study was to investigate ...
Published in Journal of Medical Virology
Italy is the first western country suffering heavy SARS‐CoV‐2 transmission and disease impact after Covid‐19 pandemia started in China. Even though the presence of mutations on spike glycoprotein and nucleocapsid in Italian isolates has been reported, the potential impact of these mutations on viral transmission has not been evaluated. We have comp...
Version deposé et non-validée par les rapporteurs
Published in Life sciences
The aim of the presente study was to examine the effects of oral gallic acid (GA) administration on the brown adipose tissue of obese mice fed with high-fat diet. New mechanisms and interactions pathways in thermogenesis were accessed through bioinformatics analyses. Swiss male mice were divided into four groups and fed during 60 days with: standar...
Le Syndrome de Taybi-Linder (TALS) est une maladie génétique rare affectant le développement embryonnaire, caractérisée par un nanisme microcéphalique sévère et un décès précoce des patients. Le gène muté dans ce syndrome est RNU4ATAC, qui encode un petit ARN nucléaire (snRNA) non-codant : U4atac. Ce snRNA est l’une des briques composant le spliceo...
L’exploitation conjointe des données transcriptomiques et protéomiques permet l’étude détaillée des mécanismes moléculaires induits lors de perturbations environnementales. L’assemblage de données issues du séquençage des ARNs d’organismes dit « non-modèle » permet de produire la base de données pour l’interprétation des spectres générés en protéom...
Published in Journal of chemical neuroanatomy
Depression is a debilitating mental illness, one of the most prevalent worldwide. MicroRNAs have been studied to better understand the biological mechanisms that regulate this disease. This study review systematically the literature to identify which microRNAs are currently being associated with depression and their related pathways. The electronic...
Vsako leto se na področju bioinformatike izvede na stotine novih raziskav. Rezultati le teh so razdrobljeni po različnih podatkovnih bazah, ki so med seboj nepovezane, ali pa sploh niso dostopne preko spleta. Vse več znanstvenikov zanima, če bi lahko te podatke združili in izluščili odvisne medsebojne povezave med podatki. V magistrskem delu predla...
Published in BMC Cancer
BackgroundGastric cancer (GC) is one of the most commonly occuring gastrointestinal tumor types, and early diagnosis and operation have a notable effect on the prognosis of patients. Although certain markers, including HER2, VEGER-2, ERCC1 and Bcl-2, have been utilized in clinical practise to screen out new patients with GC, the results of using th...
Published in Current computer-aided drug design
Apolipoprotein E4 (ApoE) is a major genetic risk factor due to its increase incidence of developing Alzheimer's disease (AD). ApoE plays a major role in the brain to maintain a constant supply of neuronal lipids for rapid and dynamic membrane synthesis. Aggregation of beta amyloid plaques (Aβ) and neurofibrillary tangles in the brain has responsibl...
