Published in BMC Cancer
BackgroundAn important mechanism that promoter methylation-mediated gene silencing for gene inactivation is identified in human tumorigenesis. Methylated genes have been found in breast cancer (BC) and beneficial biomarkers for early diagnosis. Prognostic assessment of breast cancer remain little known. Zinc finger protein 132 (ZNF132) is downregul...
Published in Chemotherapy
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped virus initially detected in Wuhan in December 2019, responsible for coronavirus disease 2019 (COVID-19), a respiratory syndrome currently affecting >220 countries around the world, with >80 million cases registered and >1.8 million deaths. Objective: As several...
Published in BMC Cancer
BackgroundDespite advances in early diagnosis and treatment, cancer remains the leading cause of mortality worldwide. The insulin-like growth factor 2 mRNA binding protein (IGF2BP) family has been reported to be involved in a variety of human malignant tumours. However, little is known about their expression and prognostic value in human pancreatic...
Les nouvelles technologies de séquençage (NGS) ont révolutionné nos approches de la génomique.De nombreux génomes d'organismes ont été séquencés et assemblés.Le décryptage de l'information qu'ils contiennent (annotation) est plus que jamais une étape cruciale.Dans ce manuscrit, je vais me focaliser sur l’impact qu'ont eu les NGS sur l'annotation de...
Published in Journal of Translational Medicine
BackgroundGlioblastoma multiforme (GBM) is the most malignant tumor in human brain. Diagnosis and treatment of GBM may lead to psychological disorders such as depressive and anxiety disorders. There was no research focusing on the correlation between depressive/anxiety disorder and the outcome of GBM. Thus, the aim of this study was to investigate ...
Version deposé et non-validée par les rapporteurs
Published in Journal of Medical Virology
Italy is the first western country suffering heavy SARS‐CoV‐2 transmission and disease impact after Covid‐19 pandemia started in China. Even though the presence of mutations on spike glycoprotein and nucleocapsid in Italian isolates has been reported, the potential impact of these mutations on viral transmission has not been evaluated. We have comp...
Published in Life sciences
The aim of the presente study was to examine the effects of oral gallic acid (GA) administration on the brown adipose tissue of obese mice fed with high-fat diet. New mechanisms and interactions pathways in thermogenesis were accessed through bioinformatics analyses. Swiss male mice were divided into four groups and fed during 60 days with: standar...
Le Syndrome de Taybi-Linder (TALS) est une maladie génétique rare affectant le développement embryonnaire, caractérisée par un nanisme microcéphalique sévère et un décès précoce des patients. Le gène muté dans ce syndrome est RNU4ATAC, qui encode un petit ARN nucléaire (snRNA) non-codant : U4atac. Ce snRNA est l’une des briques composant le spliceo...
L’exploitation conjointe des données transcriptomiques et protéomiques permet l’étude détaillée des mécanismes moléculaires induits lors de perturbations environnementales. L’assemblage de données issues du séquençage des ARNs d’organismes dit « non-modèle » permet de produire la base de données pour l’interprétation des spectres générés en protéom...
